其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Methylprednisolone CAS Registry Number: 83-43-2 甲基泼尼松龙

CAS Name: (6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
Additional Names: 1-dehydro-6a-methylhydrocortisone; D1-6a-methylhydrocortisone; 6a-methyl-11b,17a,21-triol-1,4-pregna...
Literature References: Prepn: Spero et al., J. Am. Chem. Soc. 78, 6213 (1956); Fried, ibid. 81, 1235 (1959); Sebek, Spero, US 2897218 (1959 to Upjohn); Gould, US 3053832 (1962 to Schering). Review of clinical toxicology: J. D. Truwit, Crit. Care Clin. 7, 639-657 (1991); of neuroprotective pharmacology: E. D. Hall, J. Neurosurg. 76, 13-22 (1992); of pharmacokinetics and clinical efficacy in multiple sclerosis: O. R. Hommes et al., Mult. Scler. 1, 327-328 (1996). Clinical trial in acute spinal cord injury: M. B. Bracken et al., J. Neurosurg. 89, 699 (1998); in carpel tunnel syndrome: J. W. H. H. Dammers et al., Br. Med. J. 319, 884 (1999).

Triamterene CAS Registry Number: 396-01-0 氨苯蝶啶

CAS Name: 6-Phenyl-2,4,7-pteridinetriamine
Additional Names: 2,4,7-triamino-6-phenylpteridine; 6-phenyl-2,4,7-triaminopteridine; ademin(e); pterofen; pteropheneTrademarks: Dyren (Sejin); Dyreni...
Literature References: Prepn: Spickett, Timmis, J. Chem. Soc. 1954, 2887; Pachter, J. Org. Chem. 28, 1191 (1963); Weinstock, Wiebelhaus, US 3081230 (1963 to SK F); Osdene et al., J. Med. Chem. 10, 431 (1967). Review: Ther. Triamteren Wien. Symp. 1966, K. Fellinger, Ed. (Georg Thieme, Vienna, 1967). Comprehensive description: V. K. Kapoor, Anal. Profiles Drug Subs. Excip. 23, 571-605 (1994).

Paramethadione CAS Registry Number: 115-67-3 甲乙双酮

CAS Name: 5-Ethyl-3,5-dimethyl-2,4-oxazolidinedione
Additional Names: 3,5-dimethyl-5-ethyloxazolidine-2,4-dione
Trademarks: Paradione (Abbott)
Percent Composition: C 53.49%, H 7.05%, N 8....
Literature References: Prepn: Spielman, US 2575693 (1951 to Abbott).

Phethenylate Sodium CAS Registry Number: 510-34-9

CAS Name: 5-Phenyl-5-(2-thienyl)-2,4-imidazolidinedione monosodium salt
Additional Names: 5-phenyl-5-(2-thienyl)hydantoin sodium; sodium 5-phenyl-5-(2-thienyl)hydantoinate
Trademarks: Thiant...
Literature References: Prepn: Spurlock, US 2366221 (1942).

Isatropic Acid CAS Registry Number: 596-56-5 Α-二聚顛茄酸

CAS Name: 1,2,3,4-Tetrahydro-1-phenyl-1,4-naphthalenedicarboxylic acid
Additional Names: 1-phenyltetrahydro-1,4-naphthalenedicarboxylic acid; 1-phenyltetralin-1,4-dicarboxylic acid; diatropic a...
Literature References: Prepn: Staudinger, Ruzicka, Ann. 380, 296 (1911); Smith, Forsberg, C.A. 42, 7283 (1948). Structure: Voigtlander, Engelbert, Ann. 625, 196 (1959).

Diamthazole Dihydrochloride CAS Registry Number: 136-96-9 2-苯并硫杂氮醇胺,6-[2-(二乙胺基)乙氧基]-N,N-二甲基-,盐酸盐

CAS Name: 6-[2-(Diethylamino)ethoxy]-N,N-dimethyl-2-benzothiazolamine dihydrochloride
Additional Names: 6-[2-(diethylamino)ethoxy]-2-dimethylaminobenzothiazole dihydrochloride; 2-dimethylamino-...
Literature References: Prepn: Steiger, Keller, US 2578757 (1951 to Hoffmann-La Roche).

Propyphenazone CAS Registry Number: 479-92-5 4-异丙基安替比林

CAS Name: 1,2-Dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-3H-pyrazol-3-one
Additional Names: 4-isopropylantipyrine; 4-isopropyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one; 2,3-dimethyl-1-pheny...
Literature References: Prepn: Stenz, US 1972036 (1934 to Hoffmann-La Roche); Sawa, J. Pharm. Soc. Jpn. 57, 953 (1937), C.A. 32, 2533 (1938).

Halethazole CAS Registry Number: 15599-36-7 哈利他唑

CAS Name: 5-Chloro-2-[p-(diethylaminoethoxy)phenyl]benzothiazole
Additional Names: 2-[p-(diethylaminoethoxy)phenyl]-5-chlorobenzothiazole; haletazole
Trademarks: Episol
Percent Compositio...
Literature References: Prepn: Stephens, US 2996512 (1961 to Crookes Labs.).

Clopidol CAS Registry Number: 2971-90-6 氯羟吡啶

CAS Name: 3,5-Dichloro-2,6-dimethyl-4-pyridinol
Additional Names: meticlorpindol; clopindol
Trademarks: Coyden (Dow)
Percent Composition: C 43.78%, H 3.67%, Cl 36.92%, N 7.29%, O 8.33%
Literature References: Prepn: Stevenson, US 3206358 (1965 to Dow). Metabolism studies in chickens: Smith, Poult. Sci. 48, 420 (1969). Toxicity study: Plisek et al., Vet. Spofa 12, 111 (1970), C.A. 74, 138780p (1971).

Nidroxyzone CAS Registry Number: 405-22-1 尼屈昔腙

CAS Name: 1-(2-Hydroxyethyl)-2-[(5-nitro-2-furanyl)methylene]hydrazinecarboxamide
Additional Names: 5-nitro-2-furaldehyde 2-(2-hydroxyethyl)semicarbazoneTrademarks: Furadroxyl (Eaton)
Percen...
Literature References: Prepn: Stillman, Scott, US 2416234 (1947 to Eaton).