Triamterene CAS Registry Number: 396-01-0 氨苯蝶啶
CAS Name: 6-Phenyl-2,4,7-pteridinetriamine
Additional Names: 2,4,7-triamino-6-phenylpteridine; 6-phenyl-2,4,7-triaminopteridine; ademin(e); pterofen; pteropheneTrademarks: Dyren (Sejin); Dyrenium (SKB); Dytac (Bridge); Jatropur (Procter Gamble); Teriam (Roussel Diamant); Triteren (Sumitomo); Urocaudal (Jorba)
Percent Composition: C 56.91%, H 4.38%, N 38.71%
📌 参考资料/链接：
Literature References: Prepn: Spickett, Timmis, J. Chem. Soc. 1954, 2887; Pachter, J. Org. Chem. 28, 1191 (1963); Weinstock, Wiebelhaus, US 3081230 (1963 to SK F); Osdene et al., J. Med. Chem. 10, 431 (1967). Review: Ther. Triamteren Wien. Symp. 1966, K. Fellinger, Ed. (Georg Thieme, Vienna, 1967). Comprehensive description: V. K. Kapoor, Anal. Profiles Drug Subs. Excip. 23, 571-605 (1994).
📄 详细内容
Properties: Yellow plates from butanol, mp 316° (Spickett, Timmis); also reported as crystals from DMF, mp 327° (Osdene et al.). pKa 6.2. Practically insol in ether. Sol in formic acid. Slight sol in water (1 in 1000), ethanol (1 in 3000), chloroform (1 in 4000). uv max (4.5% formic acid): 356 nm (e 21000).
Melting point: mp 316° (Spickett, Timmis); mp 327° (Osdene et al.)
pKa: pKa 6.2
Absorption maximum: uv max (4.5% formic acid): 356 nm (e 21000)
Therap-Cat: Diuretic.
Keywords: Diuretic.
产品链接: 396-01-0››