其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Nihydrazone CAS Registry Number: 67-28-7 尼海屈腙

CAS Name: Acetic acid [(5-nitro-2-furanyl)methylene]hydrazide
Additional Names: acetic acid 5-(nitrofurfurylidene)hydrazide; 5-nitro-2-furaldehyde acetylhydrazone; N-acetyl-5-nitro-2-furaldehyd...
Literature References: Prepn: Stillman, Scott, US 2416234 and US 2416236 (1947 to Eaton Labs).

Nifuraldezone CAS Registry Number: 3270-71-1 硝呋地腙

CAS Name: Aminooxoacetic acid [(5-nitro-2-furanyl)methylene]hydrazide
Additional Names: 5-nitro-2-furaldehyde semioxamazone
Trademarks: Furamazone (Eaton)
Percent Composition: C 37.18%, H...
Literature References: Prepn: Stillman, Scott, US 2416238 (1947 to Eaton Labs.).

Propylparaben CAS Registry Number: 94-13-3 对羟基苯甲酸丙酯

CAS Name: 4-Hydroxybenzoic acid propyl ester
Additional Names: propyl p-hydroxybenzoate
Trademarks: Nipasol M (Nipa); Solbrol P (Bayer); Propyl Parasept (Tenneco)
Percent Composition: C 6...
Literature References: Prepn: Stohmann, J. Prakt. Chem. 36, 368 (1887); L. Nobli, Giorn. Farm. Chim. 84, 168 (1935), C.A. 30, 34239 (1936). Review of safety assessment: M. G. Soni et al., Food Chem. Toxicol. 39, 513-532 (2002).

Methyl N-Methylnipecotate CAS Registry Number: 1690-72-8 1-甲基-3-哌啶甲酸甲酯

CAS Name: 1-Methyl-3-piperidinecarboxylic acid methyl ester
Additional Names: N-methylnipecotic acid methyl ester; dihydroarecoline
Percent Composition: C 61.12%, H 9.62%, N 8.91%, O 20.35%
Literature References: Prepn: Stoll et al., Helv. Chim. Acta 33, 375 (1950); Sperber et al., J. Am. Chem. Soc. 81, 704 (1959). Electron distribution and dissociation constants: E. Mutschler et al., Arzneim.-Forsch. 17, 833 (1967). Pharmacologic studies: O. Nieschulz, ibid. 22, 804 (1972). Structure-conformation activity study: G. Lambrecht, E. Mutschler, ibid. 24, 1725 (1974).

Thenaldine CAS Registry Number: 86-12-4 西那利定

CAS Name: 1-Methyl-N-phenyl-N-(2-thienylmethyl)-4-piperidinamine
Additional Names: 1-methyl-4-N-2-thenylanilinopiperidine; 1-methyl-4-amino-N-phenyl-N-(2-thenyl)piperidine; thenophenopiperidine...
Literature References: Prepn: Stoll, Bourquin, US 2717251 and US 2757175 (1955 and 1956 to Sandoz).

p-Hydroxyephedrine CAS Registry Number: 365-26-4 甲基辛弗林盐酸盐

CAS Name: 4-Hydroxy-a-[1-(methylamino)ethyl]benzenemethanol
Additional Names: p-hydroxy-a-[1-(methylamino)ethyl]benzyl alcohol; 1-(4-hydroxyphenyl)-2-methylaminopropanol; a-(1-methylaminoethyl)...
Literature References: Prepn: Stolz, US 1878021 (1932 to Winthrop). Prepn of hydrochlorides of d- and l-forms: Takamatsu, Minaki, J. Pharm. Soc. Jpn. 76, 1230 (1956), C.A. 51, 4305e (1957).

Carpronium Chloride CAS Registry Number: 13254-33-6 卡普氯铵

CAS Name: 3-Carboxy-N,N,N-trimethyl-1-propanaminium chloride methyl ester
Additional Names: (3-carboxypropyl)trimethylammonium chloride methyl ester; g-butyrobetaine chloride methyl ester; meth...
Literature References: Prepn: Strack, Försterling, Ber. 76B, 14 (1943).

Phthalofyne CAS Registry Number: 131-67-9 酞己炔酯

CAS Name: 1,2-Benzenedicarboxylic acid mono(1-ethyl-1-methyl-2-propynyl) ester
Additional Names: phthalic acid 1-ethyl-1-methyl-2-propynyl ester; 1-ethyl-1-methyl-2-propynyl acid phthalate; 3-m...
Literature References: Prepn: Sugimoto, Okumura, JP 54 1833 (1954 to Tanabe), C.A. 49, 11711e (1955); GB 736993 (1955 to Schering).

DFDT CAS Registry Number: 475-26-3 1,1'-(2,2,2-三氯乙亚基)二(4-氟苯)

CAS Name: 1,1'-(2,2,2-Trichloroethylidene)bis[4-fluorobenzene]
Additional Names: 1,1,1-trichloro-2,2-bis(p-fluorophenyl)ethane; difluorodiphenyltrichloroethane; fluorogesarolTrademarks: Gix
...
Literature References: Prepn: Sumerford, J. Am. Pharm. Assoc. 36, 127 (1947); Cross, US 2581174 (1952). Toxicity: Piekarski, Holz, Arch. Exp. Pathol. Pharmakol. 210, 71 (1950).

Chlorbetamide CAS Registry Number: 97-27-8 氯倍他胺

CAS Name: 2,2-Dichloro-N-[(2,4-dichlorophenyl)methyl]-N-(2-hydroxyethyl)acetamide
Additional Names: 2,2-dichloro-N-(2,4-dichlorobenzyl)-N-(2-hydroxyethyl)acetamide; N-(2,4-dichlorobenzyl)-N-(2-...
Literature References: Prepn: Surrey, J. Am. Chem. Soc. 76, 2214 (1954); US 2732402 (1956 to Sterling Drug).