其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Dimoxyline CAS Registry Number: 147-27-3 地莫昔林

CAS Name: 1-(4-Ethoxy-3-methoxybenzyl)-6,7-dimethoxy-3-methylisoquinoline
Additional Names: 6,7-dimethoxy-3-methyl-1-(3'-methoxy-4'-ethoxybenzyl)isoquinoline; 6,7-dimethoxy-1-(4'-ethoxy-3'-meth...
Literature References: Prepn: Shepard, US 2728769 (1955 to Lilly).

Dibutyltin Dilaurate CAS Registry Number: 77-58-7 二月桂酸二丁基锡

CAS Name: Dibutylbis[(1-oxododecyl)oxy]stannane
Additional Names: dibutylbis(lauroyloxy)tin
Trademarks: Butynorate; Davainex; Tinostat
Percent Composition: C 60.86%, H 10.21%, O 10.13%, S...
Literature References: Prepn: Sheverdina et al., Khim. Prom. 1962 (10), 707, C.A. 59, 8776f (1963); FR 1320473 (1963 to Noury van der Lande), C.A. 59, 8789b (1963), corresp to GB 975369. Compd claimed but not described: Eberly, US 2560034 (1951 to Firestone).

Flopropione CAS Registry Number: 2295-58-1 夫洛丙酮

CAS Name: 1-(2,4,6-Trihydroxyphenyl)-1-propanone
Additional Names: 2',4',6,-trihydroxypropiophenone; phloropropiophenoneTrademarks: Argobyl (Specia); Cospanon (Eisai); Flopion (Kyoritsu); Galle...
Literature References: Prepn: Shinoda, J. Pharm. Soc. Jpn. 1927, 111; Canter et al., J. Chem. Soc. 1931, 1245; Howells, Little, J. Am. Chem. Soc. 54, 2451 (1932).

Butabarbital Sodium CAS Registry Number: 143-81-7 仲丁比妥纳

CAS Name: 5-Ethyl-5-(1-methylpropyl)-2,4,6(1H,3H,5H)-pyrimidinetrione sodium salt
Additional Names: 5-sec-butyl-5-ethylbarbituric acid sodium salt; 5-ethyl-5-(1-methylpropyl)barbituric acid sod...
Literature References: Prepn: Shonle, US 1856792 (1932 to Lilly).

Triclofenol Piperazine CAS Registry Number: 5714-82-9 三氯酚哌嗪

CAS Name: 2,4,5-Trichlorophenol compd with piperazine (2:1)
Additional Names: bis(2,4,5-trichlorophenol) piperazine; piperazine salt of bis(2,4,5-trichlorophenol)Trademarks: Ranestol (obsolete)...
Literature References: Prepn: Short, Elslager, US 2980681 (1961 to Parke, Davis); J. Med. Pharm. Chem. 5, 642 (1962).

n-Amyl Caproate CAS Registry Number: 540-07-8 己酸戊酯

CAS Name: Hexanoic acid pentyl ester
Additional Names: pentyl hexanoate; n-caproic acid n-amyl ester
Percent Composition: C 70.92%, H 11.90%, O 17.18%
Literature References: Prepn: Simonini, Monatsh. Chem. 13, 320 (1892).

Triafur CAS Registry Number: 712-68-5 5-(5-硝基呋喃-2-基)-1,3,4-噻二唑-2-胺

CAS Name: 2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole
Additional Names: 2-(5-nitro-2-furyl)-5-amino-1,3,4-thiadiazole
Trademarks: Furidiazina
Percent Composition: C 33.96%, H 1.90%, N 2...
Literature References: Prepn: Skagius et al., Acta Chem. Scand. 14, 1054 (1960); Skagius, GB 852795 (1960 to Pharmacia); Sherman, J. Org. Chem. 26, 88 (1961). Bacteriostatic and fungistatic activity: Jeney, Zsolnai, Zentralbl. Bakteriol., Parasitenk., Infektionskr., Hyg., Abt. I Orig. 204, 430 (1967).

Formaldehyde Sodium Bisulfite CAS Registry Number: 870-72-4 羟甲基磺酰钠

CAS Name: Hydroxymethanesulfonic acid monosodium salt
Additional Names: sodium formaldehydebisulfite; methylolsulfonic acid sodium salt
Percent Composition: C 8.96%, H 2.26%, Na 17.15%, O 47...
Literature References: Prepn: Skrabal, Skrabal, Monatsh. Chem. 69, 17 (1936); Chhabria et al., DE 1173059 (1964 to Schill Seilacher). Structure: Lauer, Langkammerer, J. Am. Chem. Soc. 57, 2360 (1935); Caughlan, Tartar, ibid. 63, 1266 (1941).

Gravitol(e) CAS Registry Number: 6006-09-3 N,N-二乙基-2-[2-甲氧基-6-(2-丙烯基)苯氧基]乙胺

CAS Name: 2-(2-Allyl-6-methoxyphenoxy)triethylamine
Additional Names: 2-methoxy-6-allylphenol diethylaminoethyl ether
Trademarks: Clavitol; Uterol
Percent Composition: C 72.96%, H 9.57%, ...
Literature References: Prepn: Slotta, Grundriss der modernen Arzneistoff-Synthese (Stuttgart, 1931) p 118; H. Hahl, DE 433182 (1926 to I.G. Farbenind.), Frdl. 15, 1500; Chem. Zentralbl. 1926, II, 2223; H. Pal'gi, Zh. Obshch. Khim. Eng. Ed. 28, 2275 (1958). Pharmacology: E. Käer, G. Barkan, Arch. Exp. Pathol. Pharmakol. 170, 111 (1933).

Apronalide CAS Registry Number: 528-92-7 丙戊酰脲

CAS Name: N-(Aminocarbonyl)-2-(1-methylethyl)-4-pentenamide
Additional Names: (2-isopropyl-4-pentenoyl)urea; allylisopropylacetylurea
Trademarks: Apronal (Baxter); Sedormid (Roche)
Percen...
Literature References: Prepn: Slotta, Grundriss der modernen Arzneistoff-Synthese (Stuttgart, 1931) p 35.