其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Aminopropylon CAS Registry Number: 3690-04-8 氨丙吡酮

CAS Name: N-(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-2-(dimethylamino)propanamide
Additional Names: N-(antipyrinyl)-2-(dimethylamino)propionamide; 4-[2-(dimethylamino)propionam...
Literature References: Prepn: Takahashi et al., J. Pharm. Soc. Jpn. 75, 1431 (1955), C.A. 50, 10086d (1956); Ogiu, Takahashi, JP 58 8770 (1958 to Res. Found. for Practical Life), C.A. 54, 4621f (1960).

Cetotiamine CAS Registry Number: 137-76-8 西托硫胺

CAS Name: Thiocarbonic acid O-ethyl ester, S-ester with N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(4-hydroxy-2-mercapto-1-methyl-1-butenyl)formamide ethyl carbonate (ester)
Additional Names:...
Literature References: Prepn: Takamizawa, Hirai, Chem. Pharm. Bull. 10, 1102 (1962); Takamizawa et al., ibid. 1107; Yamamoto et al., Bitamin 25, 472 (1962), C.A. 60, 9773e (1964); GB 944641 (1963 to Shionogi).

Echothiophate Iodide CAS Registry Number: 513-10-0 碘依可酯

CAS Name: 2-[(Diethoxyphosphinyl)thio]-N,N,N-trimethylethanaminium iodide
Additional Names: (2-mercaptoethyl)trimethylammonium iodide O,O-diethyl phosphorothioate; diethoxyphosphinylthiocholine...
Literature References: Prepn: Tammelin, Acta Chem. Scand. 11, 1340 (1957); Fitch, US 2911430 (1959 to Campbell Pharmaceuticals). Comprehensive description: R. D. Daley, Anal. Profiles Drug Subs. 3, 233-251 (1974).

Betamethasone CAS Registry Number: 378-44-9 倍他米松

CAS Name: (11b,16b)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
Additional Names: 9a-fluoro-16b-methylprednisolone; 16b-methyl-9a-fluoro-D1-hydrocortisone; 16b-methyl-9a-f...
Literature References: Prepn: Taub et al., J. Am. Chem. Soc. 80, 4435 (1958); Oliveto et al., ibid. 6688; Taub et al., ibid. 82, 4012 (1960); US 3053865 (1962 to Merck Co.); Amiard et al., US 3104246 (1963 to Roussel-UCLAF). Also prepared from hecogenin. Comprehensive description of the dipropionate ester: M. G. Ferrante, B. C. Rudy, Anal. Profiles Drug Subs. 6, 43-60 (1977).

Fluprednidene Acetate CAS Registry Number: 1255-35-2 9-氟-11beta,17,21-三羟基-16-亚甲基孕甾-1,4-二烯-3,20-二酮21-乙酸酯

CAS Name: (11b)-21-(Acetyloxy)-9-fluoro-11,17-dihydroxy-16-methylenepregna-1,4-diene-3,20-dione
Additional Names: 9a-fluoro-11b,17,21-trihydroxy-16-methylenepregna-1,4-diene-3,20-dione 21-aceta...
Literature References: Prepn: Taub et al., J. Org. Chem. 25, 2258 (1960); 29, 3486 (1964); v. Werder et al., Arzneim.-Forsch. 18, 7 (1968); Wendler, Taub; Taub, Wendler; Taub et al.; Wendler et al., US 3065239; US 3068224; US 3068226 and US 3136760 (1960 and 1964 to Merck Co.).

Reposal CAS Registry Number: 3625-25-0 二环辛烯比妥

CAS Name: 5-Bicyclo[3.2.1]oct-2-en-3-yl-5-ethyl-2,4,6(1H,3H,5H)-pyrimidinetrione
Additional Names: 5-bicyclo[3.2.1]oct-2-en-3-yl-5-ethylbarbituric acid; 5-ethyl-5-(bicyclo[3.2.1]octenyl)barbitu...
Literature References: Prepn: Taub, US 2808408 (1956 to Calanda Stiftung). Metabolism: Nielsen, Tarding, Acta Pharmacol. Toxicol. 26, 521 (1968). Toxicity: Frey, Arzneim.-Forsch. 12, 389 (1962).

Dequalinium Chloride CAS Registry Number: 522-51-0 地喹氯铵

CAS Name: 1,1'-(1,10-Decanediyl)bis-[4-amino-2-methylquinolinium chloride]
Additional Names: 1,1'-decamethylenebis[4-aminoquinaldinium chloride]; BAQD-10; decamine; dekamin
Trademarks: Decat...
Literature References: Prepn: Taylor et al., GB 745956 (1956 to Allen Hanburys), C.A. 50, 16878e (1956); Austin et al., J. Chem. Soc. 1958, 1489.

Laudexium Methyl Sulfate CAS Registry Number: 3253-60-9 1H-咪唑-5-羧酸,2-环戊基-

CAS Name: 2,2'-(1,10-Decanediyl)bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolium] bis(methyl sulfate)
Additional Names: 2,2'-decamethylenebis[1,2,3,4-te...
Literature References: Prepn: Taylor, J. Chem. Soc. 1952, 142; Eastland et al., GB 695298 (1953 to Allen Hanbury).

Diethadione CAS Registry Number: 702-54-5 地沙双酮

CAS Name: 5,5-Diethyldihydro-2H-1,3-oxazine-2,4(3H)-dione
Additional Names: 5,5-diethyl-2,3,5,6-tetrahydro-4H-1,3-oxazine-2,4-dione
Trademarks: Dioxone; Ledosten; Persisten; Tocèn (Lepetit)<...
Literature References: Prepn: Testa et al., J. Org. Chem. 24, 1928 (1959); GB 855244 (1960 to Lepetit, SpA). Toxicity study: Maffii et al., J. Pharm. Pharmacol. 13, 244 (1961).

Carbinoxamine CAS Registry Number: 486-16-8 卡比沙明

CAS Name: 2-[(4-Chlorophenyl)-2-pyridinylmethoxy]-N,N-dimethylethanamine
Additional Names: 2-[p-chloro-a-(2-dimethylaminoethoxy)benzyl]pyridine; paracarbinoxamine
Percent Composition: C 66.0...
Literature References: Prepn: Tilford, Shelton, US 2606195 (1952 to Wm. S. Merrell); Swain, US 2800485 (1957 to McNeil Labs.). Prepn of l-form: GB 905993 (1962 to McNeil Labs.), C.A. 58, 5644a (1962). Abs config of l-form: V. Barouh et al., J. Med. Chem. 14, 834 (1971). Pharmacology and toxicology: R. Cahen, Ann. Pharm. Fr. 20, 463 (1962). GLC determn in serum: D. J. Hoffman et al., J. Pharm. Sci. 72, 1342 (1983).