其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Robenidine CAS Registry Number: 25875-51-8 盐酸氯苯胍

CAS Name: Bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide
Additional Names: 1,3-bis[(p-chlorobenzylidene)amino]guanidine
Percent Composition: C 53.91%, H 3.92%, Cl 21.22%, N 20.96%
Literature References: Prepn: Tomcufcik, DE 1933112 (1970 to Am. Cyanamid), C.A. 72, 90113c (1970). Activity studies: Kantor et al., Science 168, 373 (1970); Wong et al., Biochem. Biophys. Res. Commun. 46, 621 (1972). Metabolism: Zulalian et al., 163rd Am. Chem. Soc. Meeting (Boston, April 1972) Abstracts of Papers, PEST 12, 13. Animal studies: Millard, Res. Vet. Sci. 11, 394 (1970); Joyner, Norton, ibid. 13, 279 (1972).

Piperidione CAS Registry Number: 77-03-2 3,3-二乙基哌啶-2,4-二酮

CAS Name: 3,3-Diethyl-2,4-piperidinedione
Additional Names: 3,3-diethyl-2,4-dioxopiperidine; dihyprylone
Trademarks: Sedulon (Roche); Tusseval (Marco Viti)
Percent Composition: C 63.88%, ...
Literature References: Prepn: Tsukita, J. Pharm. Soc. Jpn. 69, 194 (1949).

Acetosulfone Sodium CAS Registry Number: 128-12-1 磺胺苯砜钠

CAS Name: N-[[5-Amino-2-[(4-aminophenyl)sulfonyl]phenyl]sulfonyl]acetamide monosodium salt
Additional Names: N-6-sulfanilylmetanilylacetamide N-sodium salt; N1-acetyl-6-(sulfanilylmetanilamido)...
Literature References: Prepn: Tullar, US 2358365 (1944 to Parke, Davis).

Mytatrienediol CAS Registry Number: 5108-94-1 (16S,17R)-3-甲氧基-13,16-二甲基-7,8,9,11,12,14,15,17-八氢-6H-环戊二烯并[a]菲-16,17-二醇

CAS Name: 3-Methoxy-16-methyl-1,3,5(10)-estratriene-16b,17b-diolTrademarks: Anvene (Searle); Manvene
Percent Composition: C 75.91%, H 8.92%, O 15.17%
Literature References: Prepn: Tyner, US 2949476 (1960 to Searle).

Doxofylline CAS Registry Number: 69975-86-6 多索茶碱

CAS Name: 7-(1,3-Dioxolan-2-ylmethyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
Additional Names: 7-(1,3-dioxolan-2-ylmethyl)theophylline; 2-(7'-theophyllinemethyl)-1,3-dioxolane; doxophylli...
Literature References: Prepn: U. Avico et al., Farmaco Ed. Sci. 17, 73 (1962). Use as bronchodilator: BE 868556; J. S. Franzone, T. Tamietto, US 4187308 (1978, 1980 to Istituto Biologico Chemioterapico ABC). Pharmacology: J. S. Franzone et al., Farmaco Ed. Sci. 36, 201 (1981). Pharmacodynamics and toxicity in rats: J. S. Franzone et al., ibid. 220. HPLC determn in pharmaceutical compositions: C. Badini et al., Farmaco Ed. Prat. 37, 320 (1982). Clinical trial in obstructive pneumopathy: C. Bucca et al., Int. J. Clin. Pharmacol. Res. 11, Suppl 1, 101 (1982).

Ferric Hypophosphite CAS Registry Number: 7783-84-8 次磷酸铁

Percent Composition: Fe 22.27%, H 2.41%, O 38.27%, P 37.05%
Literature References: Prepn: U.S.D. 25th ed, p 573.

Tiaramide CAS Registry Number: 32527-55-2 噻拉米特

CAS Name: 4-[(5-Chloro-2-oxo-3(2H)-benzothiazolyl)acetyl]-1-piperazineethanol
Additional Names: 5-chloro-3-[4-(2-hydroxyethyl)-1-piperazinyl]carbonylmethyl-2-benzothiazolinone; tialamide
Per...
Literature References: Prepn: Umio et al., JP 71 15302 C.A. 75, 36127j (1971); eidem, JP 71 18752 C.A. 75, 63824r (1971); Umio, US 3661921 (1971, 1971, 1972 all to Fujisawa). Pharmacology: Takashima et al., Arzneim.-Forsch. 22, 711 (1972); Tsurumi et al., ibid. 716, 724. Metabolism: Noda et al., ibid. 732. Toxicity studies: Watanabe et al., ibid. 23, 504 (1973). Mode of antiasthmatic action: G. C. Folco et al., Pharmacol. Res. Commun. 11, 703 (1979).

Nitrovin CAS Registry Number: 804-36-4 硝呋烯腙

CAS Name: 2-[3-(5-Nitro-2-furanyl)-1-[2-(5-nitro-2-furanyl)ethenyl]-2-propenylidene]hydrazinecarboximidamide
Additional Names: [[3-(5-nitro-2-furyl)-1-[2-(5-nitro-2-furyl)vinyl]allylidene]amino...
Literature References: Prepn: Uota et al., JP 52 2673 (1952 to Toyama), C.A. 48, 2115h (1954); Uoda, Tanizaki, JP 64 4479 (1964 to Fukuju Pharm.), C.A. 62, 10412f (1965).

Beryllium Oxyacetate CAS Registry Number: 19049-40-2 碱式乙酸铍

CAS Name: Hexakis[m-(acetato-kO:kO')]-m4-oxotetraberyllium
Additional Names: beryllium oxide acetate
Percent Composition: C 35.47%, H 4.47%, Be 8.87%, O 51.19%
Literature References: Prepn: Urbain, Lacombe, Compt. Rend. 133, 874 (1901); 134, 772 (1902); Haber, van Oordt, Z. Anorg. Chem. 40, 465 (1904); Moeller et al., Inorg. Synth. 3, 9 (1950).

Acipimox CAS Registry Number: 51037-30-0 阿西莫司

CAS Name: 5-Methylpyrazinecarboxylic acid 4-oxide
Additional Names: 2-carboxy-5-methylpyrazine 4-oxideTrademarks: Olbemox (Pharmacia); Olbetam (Pharmacia)
Percent Composition: C 46.76%, H 3....
Literature References: Prepn: V. Ambrogi et al., DE 2319834; eidem, US 4002750 (1973, 1977 both to Carlo Erba). Prepn and toxicology: eidem, Eur. J. Med. Chem. 15, 157 (1980). Pharmacological profile: P. P. Lovisolo et al., Pharmacol. Res. Commun. 13, 151, 163 (1981). Pharmacokinetics: L. M. Fuccella et al., Clin. Pharmacol. Ther. 28, 790 (1980); L. Musatti et al., J. Int. Med. Res. 9, 381 (1981). Mechanism of action: K. Aktories et al., Arzneim.-Forsch. 33, 1525 (1983).