其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Bismuth Oxalate CAS Registry Number: 6591-55-5 草酸铋盐

Additional Names: Oxalic acid bismuth salt
Percent Composition: C 10.57%, Bi 61.28%, O 28.15%
Literature References: Prepn: Vanino, Zumbusch, Ber. 41, 3994 (1908); Soerbye, Kruse, Acta Chem. Scand. 16, 1662 (1962).

Methafurylene CAS Registry Number: 531-06-6 美沙呋林

CAS Name: N-(2-Furanylmethyl)-N',N'-dimethyl-N-2-pyridinyl-1,2-ethanediamine
Additional Names: 2-[(2-dimethylaminoethyl)furfurylamino]pyridine; N,N-dimethyl-N'-(2-pyridyl)-N'-furfurylethylenedi...
Literature References: Prepn: Vaughan, Anderson, J. Am. Chem. Soc. 70, 2607 (1948); Kyrides, Zienty, ibid. 71, 1122 (1949); Horclois, US 2502151 (1950 to Rhône-Poulenc).

Coumetarol CAS Registry Number: 4366-18-1 库美香豆素

CAS Name: 3,3'-(2-Methoxyethylidene)bis[4-hydroxy-2H-1-benzopyran-2-one]
Additional Names: 3,3'-(2-methoxyethylidene)bis[4-hydroxycoumarin]; 1-methoxy-2,2-bis[4-hydroxy-3-coumarinyl]ethane; 4,4...
Literature References: Prepn: Veldstra et al., Rec. Trav. Chim. 72, 358 (1953); GB 736388 and NL 80005 (both 1955 to N. V. Amsterdamsche Chininefabriek), C.A. 50, 10795a, 16874b (1956). Stereodynamics: Laruelle, Tetrahedron Lett. 1970, 2235. Has antivitamin K action. Activity studies: de Jongh, Kok, Arch. Int. Pharmacodyn. 94, 470 (1953); Gilgenkrantz et al., Ann. Med. Nancy 3, 115 (1964). Series of articles on clinical studies: Hutinel, Lyon Med. 23, 1569-1604 (1964).

Methyltrienolone CAS Registry Number: 965-93-5 美曲勃龙

CAS Name: (17b)-17-Hydroxy-17-methylestra-4,9,11-trien-3-one
Additional Names: 17b-hydroxy-17-methyl-19-norandrosta-4,9,11-trien-3-one; 17a-methyl-4,9,11-estratrien-17b-ol-3-one; 17a-methyl-17b...
Literature References: Prepn: Velluz et al., Compt. Rend. 257, 569 (1963); NL 6401555 (1964 to Roussel-UCLAF), C.A. 62, 10498d (1965).

Thiocolchicine CAS Registry Number: 2730-71-4 硫代秋水仙碱

CAS Name: N-[(7S)-5,6,7,9-Tetrahydro-1,2,3-trimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]acetamide
Percent Composition: C 63.59%, H 6.06%, N 3.37%, O 19.25%, S 7.72%
Literature References: Prepn: Velluz, Muller, Bull. Soc. Chim. Fr. 1954, 755; Muller, Velluz, US 2820029 (1958 to UCLAF). Prepn of 2-glucoside analog: Velluz, Muller, Bull. Soc. Chim. Fr. 1955, 194; Muller, Velluz, loc. cit.

MADU CAS Registry Number: 840-50-6 1-(2-脱氧-beta-L-赤式-呋喃戊糖基)-5-(甲基氨基)-2,4(1H,3H)-嘧啶二酮

CAS Name: 2'-Deoxy-5-(methylamino)uridine
Additional Names: 5-(methylamino)-2'-deoxyuridine
Percent Composition: C 46.69%, H 5.88%, N 16.33%, O 31.10%
Literature References: Prepn: Visser et al., Biochim. Biophys. Acta 76, 463 (1963). Active in vitro against herpes infections: Nemes, Hilleman, Proc. Soc. Exp. Biol. Med. 119, 515 (1965); Shen, US 3322627 (1967 to Merck Co.).

Prednival CAS Registry Number: 15180-00-4 泼尼松龙戊酸酯

CAS Name: (11b)-11,21-Dihydroxy-17-[(1-oxopentyl)oxy]pregna-1,4-diene-3,20-dione
Additional Names: 11b,17,21-trihydroxypregna-1,4-diene-3,20-dione 17-valerate; prednisolone 17-valeratePercent C...
Literature References: Prepn: Vitali, Ercoli, Tetrahedron Lett. 1961, 448; Ercoli, Gardi, US 3152154 (1964 to Vismara).

Talbutal CAS Registry Number: 115-44-6 5-丁烷-2-基-5-丙-2-烯基-1,3-二嗪农-2,4,6-三酮

CAS Name: 5-(1-Methylpropyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
Additional Names: 5-allyl-5-sec-butylbarbituric acid; 5-allyl-5-(1-methylpropyl)barbituric acid
Trademarks: Lotus...
Literature References: Prepn: Volwiler, J. Am. Chem. Soc. 47, 2236 (1925). Acute toxicity: E. W. Schafer, Toxicol. Appl. Pharmacol. 21, 315 (1972).

Methallatal CAS Registry Number: 115-56-0 美沙拉妥

CAS Name: 5-Ethyldihydro-5-(2-methyl-2-propenyl)-2-thioxo-4,6(1H,5H)-pyrimidinedione
Additional Names: 5-ethyl-5-(2-methylallyl)-2-thiobarbituric acid; ethyl-b-methylallylthiobarbituric acidTra...
Literature References: Prepn: Volwiler, Tabern, US 2153729 (1939 to Abbott).

Thiobutabarbital CAS Registry Number: 2095-57-0 硫仲丁比妥钠盐

CAS Name: 5-Ethyldihydro-5-(1-methylpropyl)-2-thioxo-4,6(1H,5H)-pyrimidinedione
Additional Names: 5-sec-butyl-5-ethyl-2-thiobarbituric acid; 5-ethyl-5-(1-methylpropyl)-2-thiobarbituric acid; th...
Literature References: Prepn: Volwiler, Tabern, US 2153729; US 2153731 (both 1939 to Abbott).