其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Sintropium Bromide CAS Registry Number: 79467-19-9 辛托溴铵

CAS Name: (3-endo,8-syn)-8-Methyl-8-(1-methylethyl)-3-[(1-oxo-2-propylpentyl)oxy]-8-azoniabicyclo[3.2.1]octane bromide
Additional Names: (8r)-3a-hydroxy-8-isopropyl-1aH,5aH-tropanium bromide 2-...
Literature References: Prepn: V. Bernareggi et al., EP 42365; eidem, US 4411902 (1981, 1983 both to Valeas). Clinical trial: M. Galeone, Minerva Med. 76, 1605 (1985); V. Colosi et al., Minerva Urol. Nefrol. 38, 271 (1986).

p-(2-Methylpropenyl)phenol Acetate CAS Registry Number: 53370-48-2

Additional Names: p-Acetoxyphenylisobutene; p-isobutenylphenol acetateTrademarks: Isotyl
Percent Composition: C 75.76%, H 7.42%, O 16.82%
Literature References: Prepn: v. Braun, Ann. 472, 71 (1929).

Thiram CAS Registry Number: 137-26-8 二硫化四甲基秋兰姆

CAS Name: Tetramethylthioperoxydicarbonic diamide
Additional Names: bis(dimethylthiocarbamoyl) disulfide; bis(dimethylthiocarbamyl) disulfide; tetramethylthiuram disulfide; TMTDTrademarks: Thiu...
Literature References: Prepn: v. Braun, Stechele, Ber. 35, 820 (1902); 36, 2280 (1903); Romani, C.A. 16, 854 (1922); Cummings, Simmons, Ind. Eng. Chem. 20, 1173 (1928). Acute toxicity: Gaines, Toxicol. Appl. Pharmacol. 14, 515 (1969). Review of carcinogenic risk: IARC Monographs 12, 225 (1976).

Clofazimine CAS Registry Number: 2030-63-9 氯苯吩嗪

CAS Name: N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-[(1-methylethyl)imino]-2-phenazinamine
Additional Names: 3-(p-chloroanilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)phenazine; 2-(4-c...
Literature References: Prepn: V. C. Barry et al., US 2948726 (1960 to Geigy); Barry et al., Nature 179, 1013 (1957); Barry et al., J. Chem. Soc. 1958, 859; Belton et al., Proc. R. Irish Acad. Sect. B 62, 9 (1961), C.A. 58, 4556d (1963). Activity studies: Vischer, Arzneim.-Forsch. 18, 1529 (1968). HPLC determn in plasma: J. H. Peters et al., J. Chromatogr. 229, 503 (1982). Toxicity data: Stenger et al., Arzneim.-Forsch. 20, 794 (1970). Clinical studies: Mathies, ibid. 1838; Karat et al., Br. Med. J. 1, 198 (1970). Review of clinical pharmacokinetics: M. R. Holdiness, Clin. Pharmacokinet. 16, 74-85 (1989); of clinical use: J. C. Garrelts, DICP Ann. Pharmacother. 25, 525-531 (1991). Comprehensive description: V. K. Kapoor, Anal. Profiles Drug Subs. 18, 91-120 (1989); C. M. O'Driscoll, O. I. Corrigan, Anal. Profiles Drug Subs. Excip. 21, 75-108 (1992).

Oxeladin CAS Registry Number: 468-61-1 沃克拉丁

CAS Name: a,a-Diethylbenzeneacetic acid 2-[2-(diethylamino)ethoxy]ethyl ester
Additional Names: 2-ethyl-2-phenylbutyric acid 2-(2-diethylaminoethoxy)ethyl ester; 2-(2-diethylaminoethoxy)ethyl a...
Literature References: Prepn: V. Petrow et al., J. Pharm. Pharmacol. 10, 40 (1958); eidem, US 2885404 (1959 to Brit. Drug Houses).

Fenpentadiol CAS Registry Number: 15687-18-0 芬戊二醇

CAS Name: 2-(4-Chlorophenyl)-4-methyl-2,4-pentanediol
Additional Names: 2-methyl-4-(p-chlorophenyl)-2,4-pentanediolTrademarks: Tredum (Hatrol)
Percent Composition: C 63.02%, H 7.49%, Cl 15....
Literature References: Prepn: Valette, FR M1984 (1963 to Labs Albert Rolland), C.A. 60, 2828h (1964). Psychopharmacology: J. Ginet et al., Arzneim.-Forsch. 21, 1 (1971). Pharmacokinetics: Y. Dormand, J. C. Levron, Eur. J. Toxicol. 5, 43 (1972). Clinical evaluations: P. Mouren et al., Marseille Med. 106, 555 (1969); P. J. Parquet, Lille Med. 18, 836 (1973). Toxicity: H. Kriegel et al., Arzneim.-Forsch. 21, 9 (1971).

Dichlorobenzyl Alcohol CAS Registry Number: 1777-82-8 2,4-二氯苄醇

CAS Name: 2,4-Dichlorobenzenemethanol
Trademarks: Dybenal
Percent Composition: C 47.49%, H 3.42%, Cl 40.05%, O 9.04%
Literature References: Prepn: Van de Lande, Rec. Trav. Chim. 51, 98 (1932); Metayer, Dat-Xuong, Bull. Soc. Chim. Fr. 1954, 615.

Deptropine CAS Registry Number: 604-51-3 地普托品

CAS Name: endo-3-[(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)oxy]-8-methyl-8-azabicyclo[3.2.1]octane
Additional Names: 3a-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)oxy]-1aH,5aH-tropan...
Literature References: Prepn: Van der Stelt et al., J. Med. Pharm. Chem. 4, 335 (1961). Pharmacology: Funcke et al., Arch. Int. Pharmacodyn. 148, 135 (1964); Timmerman et al., ibid. 187, 291 (1970). Metabolism: Hespe et al., ibid. 164, 397 (1966).

Dithianon CAS Registry Number: 3347-22-6 二氰蒽醌

CAS Name: 5,10-Dihydro-5,10-dioxonaphtho[2,3-b]-1,4-dithiin-2,3-dicarbonitrile
Additional Names: 1,4-dithiaanthraquinone-2,3-dicarbonitrile; 2,3-dicyano-1,4-dithiaanthraquinoneTrademarks: Delan...
Literature References: Prepn: van Schoor et al., US 2976296 (1961 to E. Merck). Properties and field trials: J. Berker et al., Proc. 2nd Br. Insectic. Fungic. Conf. 1963, 351. LC determn in technical formulations: A. R. Hanks, J. AOAC Int. 78, 1131 (1995). Environmental fate: M. Ueoka et al., Chemosphere 35, 2915 (1997). Review: E. Amadori, W. Heupt, Anal. Methods Pestic. Plant Growth Regul. 10, 181-187 (1978).

Hexacyclonate Sodium CAS Registry Number: 7009-49-6 环己醇乙酸钠

CAS Name: 1-(Hydroxymethyl)cyclohexaneacetic acid sodium salt
Additional Names: sodium 3,3-pentamethylene-4-hydroxybutyrate; sodium b,b-pentamethylene-g-hydroxybutyrate; b,b-pentamethylene-g-hy...
Literature References: Prepn: Van Wessem, Sakal; Shavel et al., US 2960441; US 3007940 (1960; 1961 to Warner-Lambert).