其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Thialbarbital CAS Registry Number: 467-36-7 硫烯比妥

CAS Name: 5-(2-Cyclohexen-1-yl)dihydro-5-(2-propenyl)-2-thioxo-4,6(1H,5H)-pyrimidinedione
Additional Names: 5-allyl-5-(2-cyclohexen-1-yl)-2-thiobarbituric acid; 5-(2-cyclohexen-1-yl)-5-allyl-2-...
Literature References: Prepn: Volwiler, Tabern, US 2153730 (1939 to Abbott).

Dimethoxanate CAS Registry Number: 477-93-0 地美索酯

CAS Name: 10H-Phenothiazine-10-carboxylic acid 2-[2-(dimethylamino)ethoxy]ethyl ester
Additional Names: b-dimethylaminoethoxyethyl phenothiazine-10-carboxylate
Trademarks: Tussidin; Cotrane ...
Literature References: Prepn: von Seeman, US 2778824 (1957 to American Home Prod.).

Cyclovalone CAS Registry Number: 579-23-7 环香草酮

CAS Name: 2,6-Divanillylidenecyclohexanone
Additional Names: 2,6-bis(4-hydroxy-3-methoxybenzylidene)cyclohexanone; divanillalcyclohexanone
Trademarks: Beveno (Fischer); Divanil; Divanon (obs...
Literature References: Prepn: Vorländer, Koch, Ber. 62, 534 (1929); Rumpel, AT 180258 (1954 to Chem-Pharm. Fabrik Waldheim).

Indecainide CAS Registry Number: 74517-78-5 英地卡胺

CAS Name: 9-[3-[(1-Methylethyl)amino]propyl]-9H-fluorene-9-carboxamide
Additional Names: 9-carbamoyl-9-(3-isopropylaminopropyl)fluorene; 9-[3-(isopropylamino)propyl]-9-(aminocarboyl)fluorene; r...
Literature References: Prepn: W. B. Lacefield, R. L. Simon, US 4197313 and US 4452745 (1980, 1984 both to Lilly). Pharmacokinetics in animals: T. L. Lindstrom, G. W. Whitaker, Drug Metab. Dispos. 12, 683 (1984). Metabolism: eidem, ibid. 691. LC determn in biological fluids: K. Z. Farid et al., J. Chromatogr. 337, 329 (1985). Toxicological studies: G. E. Sandusky, Jr., D. B. Meyers, Fundam. Appl. Toxicol. 5, 175 (1985). Clinical evaluation in cardiac arrhythmias: P. F. Nestico et al., Am. J. Cardiol. 59, 1332 (1987); P. J. Podrid et al., ibid. 61, 764 (1988).

Febuprol CAS Registry Number: 3102-00-9 非布丙醇

CAS Name: 1-Butoxy-3-phenoxy-2-propanolTrademarks: Valbil (Procter Gamble)
Percent Composition: C 69.61%, H 8.99%, O 21.40%
Literature References: Prepn: W. F. Minor et al., J. Am. Chem. Soc. 76, 2993 (1954). Prepn and use as choleretic: H. Hoffmann et al., DE 2120396; eidem, US 3839587 (1972, 1974 both to Klinge). Pharmacology: G. Hofrichter et al., Arzneim.-Forsch. 24, 111 (1974). Pharmacokinetics, metabolism: K. Rehm et al., ibid. 26, 813 (1976). Spasmolytic action: R. Eisenburger, ibid. 27, 1429 (1977). Clinical studies: C. Wolf et al., Muench. Med. Wochenschr. 118, 1285 (1976); W. E. Scholing, W. Weinert, ibid. 120, 143 (1978); U. Ritter, H. J. Kyrein, Arzneim.-Forsch. 33, 891 (1983).

Fenclozic Acid CAS Registry Number: 17969-20-9 2-(2-(4-氯苯基)噻唑-4-基)乙酸

CAS Name: 2-(4-Chlorophenyl)-4-thiazoleacetic acid
Additional Names: 2-(p-chlorophenyl)thiazol-4-ylacetic acid; acidum fenclozicumTrademarks: Myalex (ICI)
Percent Composition: C 52.08%, H 3....
Literature References: Prepn: W. Hepworth, G. J. Stacey, NL 6614130; eidem, US 3538107 (1967, 1970 both to ICI); Aries, FR 1561433 (1969), C.A. 72, 43654y (1970). Pharmacology: W. Hepworth et al., Nature 221, 582 (1969); Newbould, Br. J. Pharmacol. 35, 487 (1969). Metabolic studies: Foulkes, J. Pharmacol. Exp. Ther. 172, 115, 449 (1970). Clinical evaluation: Chalmers et al., Ann. Rheum. Dis. 28, 590, 595 (1969).

Guanoxabenz CAS Registry Number: 24047-25-4 胍诺沙苄

CAS Name: 2-[(2,6-Dichlorophenyl)methylene]-N-hydroxyhydrazinecarboximidamide
Additional Names: 1-[(2,6-dichlorobenzylidene)amino]-3-hydroxyguanidinePercent Composition: C 38.89%, H 3.26%, Cl 2...
Literature References: Prepn: W. J. Houlihan, R. E. Manning, DE 1902449; eidem, US 3591636 (1969, 1971 both to Sandoz). Pharmacological study: J. C. Doxey, A. S. Hersom, Br. J. Pharmacol. 70, 171 (1980).

Biperiden CAS Registry Number: 514-65-8 比哌立登

CAS Name: a-Bicyclo[2.2.1]hept-5-en-2-yl-a-phenyl-1-piperidinepropanol
Additional Names: a-5-norbornen-2-yl-a-phenyl-1-piperidinepropanol; 3-piperidino-1-phenyl-1-bicycloheptenyl-1-propanol; 1-...
Literature References: Prepn: W. Klavehn, US 2789110 (1957 to Knoll). Toxicology study: C. Hanna, Toxicol. Appl. Pharmacol. 2, 379 (1960).

d-Amyl Bromide CAS Registry Number: 534-00-9 (S)-1-溴-2-甲基丁烷

CAS Name: 1-Bromo-2-methylbutane
Additional Names: d-pri-act-amyl bromide; L-1-bromo-2-methylbutane
Percent Composition: C 39.76%, H 7.34%, Br 52.90%
Literature References: Prepn: W. Marckwald, Ber. 37, 1038 (1904); H. O. Jones, J. Chem. Soc. 87, 135 (1905); R. P. Frohardt et al., J. Am. Chem. Soc. 81, 5500 (1959).

Fenoprofen CAS Registry Number: 31879-05-7 菲诺洛芬

CAS Name: a-Methyl-3-phenoxybenzeneacetic acid
Additional Names: (±)-m-phenoxyhydratropic acid; a-dl-2-(3-phenoxyphenyl)propionic acidPercent Composition: C 74.36%, H 5.82%, O 19.81%
Literature References: Prepn: W. S. Marshall, FR 2015728; eidem, US 3600437 (1970, 1971 both to Lilly). Pharmacology: Rubin et al., J. Pharm. Sci. 60, 1797 (1971); 61, 800 (1972); Herrmann, Proc. Soc. Exp. Biol. Med. 139, 548 (1972). Metabolism: Rubin et al., J. Pharmacol. Exp. Ther. 183, 449 (1972). Toxicology: J. L. Emmerson et al., Toxicol. Appl. Pharmacol. 25, 444 (1973). Comprehensive description: C. K. Ward, R. E. Schirmer, Anal. Profiles Drug Subs. 6, 161-182 (1977). Review: R. N. Brogden et al., Drugs 13, 241-265 (1977); R. Nickander et al., in Pharmacological and Biochemical Properties of Drug Substances vol. 1, M. E. Goldberg, Ed. (Am. Pharm. Assoc., Washington, DC, 1977) pp 183-213.