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Biperiden CAS Registry Number: 514-65-8 比哌立登

CAS Name: a-Bicyclo[2.2.1]hept-5-en-2-yl-a-phenyl-1-piperidinepropanol
Additional Names: a-5-norbornen-2-yl-a-phenyl-1-piperidinepropanol; 3-piperidino-1-phenyl-1-bicycloheptenyl-1-propanol; 1-bicycloheptenyl-1-phenyl-3-piperidinopropanol; 3-piperidino-1-phenyl-(D5-bicyclo[2.2.1]hepten-2-yl)-1-propanolPercent Composition: C 80.98%, H 9.38%, N 4.50%, O 5.14%

📌 参考资料/链接：
Literature References: Prepn: W. Klavehn, US 2789110 (1957 to Knoll). Toxicology study: C. Hanna, Toxicol. Appl. Pharmacol. 2, 379 (1960).

📄 详细内容

Properties: Crystals, mp 101°. Difficultly sol in water; slightly sol in ethanol; readily sol in methanol. LD50 in mice (mg/kg): 195 s.c., 56 i.v. (Klavehn).
Melting point: mp 101°
Toxicity data: LD50 in mice (mg/kg): 195 s.c., 56 i.v. (Klavehn)
Derivative Type: Hydrochloride
CAS Registry Number: 1235-82-1
Trademarks: Akineton (Knoll); Akinophyl (Knoll)
Percent Composition: C 72.50%, H 8.69%, N 4.03%, O 4.60%, Cl 10.19%
Properties: Fluffy white powder, mp 238°. Soly in water (mg/100 ml) at 30°: 220 (pH 3.8), 280 (pH 5.5), 290 (pH 6.7), 264 (pH 7.9), 244 (9.2-10.1). LD50 in rats, dogs (mg/kg): 750, 340 orally (Hanna).
Melting point: mp 238°
Toxicity data: LD50 in rats, dogs (mg/kg): 750, 340 orally (Hanna)
Therap-Cat: Antiparkinsonian.
Keywords: Antiparkinsonian; Antimuscarinic.
产品链接: 514-65-8››

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