其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Teclozan CAS Registry Number: 5560-78-1 替克洛占

CAS Name: N,N'-[1,4-Phenylenebis(methylene)]-bis[2,2-dichloro-N-(2-ethoxyethyl)acetamide]
Additional Names: N,N'-bis(ethoxyethyl)-N,N'-bis(dichloroacetyl)-1,4-xylylenediamine; N,N'-bis(dichloro...
Literature References: Prepn: Surrey, Mayer, J. Med. Pharm. Chem. 3, 409 (1961). Amebicidal activity and toxicity: Berberian et al., Am. J. Trop. Med. Hyg. 10, 503 (1961).

Penicillamine Disulfide CAS Registry Number: 312-10-7 (2R)-2-氨基-3-[(3R)-3-氨基-4-羟基-2-甲基-4-氧代丁烷-2-基]二硫基-3-甲基丁酸

CAS Name: 3,3'-Dithiobisvaline
Additional Names: 3,3'-dithiodivaline; 3,3,3',3'-tetramethylcystine
Percent Composition: C 40.52%, H 6.80%, N 9.45%, O 21.59%, S 21.64%
Literature References: Prepn: Süs, Ann. 561, 31 (1948); Berg et al., GB 621915 (1949 to Merck Co.); Butenandt et al., Z. Physiol. Chem. 285, 238 (1950).

Nicofuranose CAS Registry Number: 15351-13-0 烟呋糖酯

CAS Name: b-D-Fructofuranose 1,3,4,6-tetra-3-pyridinecarboxylate
Additional Names: fructose 1,3,4,6-tetranicotinate; 1,3,4,6-tetranicotinoylfructofuranose; 1,3,4,6-tetranicotinoyl-D-fructose Literature References: Prepn: Suter, Kuendig, CH 366523 (1963 to Eprova).

Procymate CAS Registry Number: 13931-64-1 丙环氨酯

CAS Name: a-Ethylcyclohexanemethanol carbamate
Additional Names: carbamic acid 1-cyclohexylpropyl ester; 1-cyclohexylpropyl carbamateTrademarks: Equipax
Percent Composition: C 64.83%, H 10.3...
Literature References: Prepn: Swierkot, GB 979236 (1960 to Comp. Franc. Matières Colorantes).

Nafronyl CAS Registry Number: 31329-57-4 萘呋胺酯

CAS Name: Tetrahydro-a-(1-naphthalenylmethyl)-2-furanpropanoic acid 2-(diethylamino)ethyl ester
Additional Names: tetrahydro-a-(1-naphthylmethyl)-2-furanpropionic acid 2-(diethylamino)ethyl est...
Literature References: Prepn: Szarvasi, Bayssat, FR 1363948 corresp to US 3334096 (1964, 1967 both to LIPHA); Szarvasi et al., Compt. Rend. 260, 3095 (1965); eidem, Bull. Soc. Chim. Fr. 1966, 1838. Activity studies: Fontaine et al., C.R. Seances Acad. Sci. Ser. D 262, 719 (1966). Metabolism and toxicology: Fontaine et al., Chim. Ther. 4, 44 (1969); Fontaine et al., J. Eur. Toxicol. 11, 40 (1969). Acute toxicity: P. Bessin et al., Eur. J. Med. Chem. 10, 291 (1975). Clinical studies: C. A. Clyne et al., Br. J. Surg. 67, 347 (1980); R. M. Greenhalgh, ibid. 68, 265 (1981).

Dimetilan CAS Registry Number: 644-64-4 2-二甲基氨基甲酰基-3-甲基-5-吡唑基-N,N-二甲基氨基甲酸酯

CAS Name: Dimethylcarbamic acid 1-[(dimethylamino)carbonyl]-5-methyl-1H-pyrazol-3-yl ester
Additional Names: dimethylcarbamic acid ester with 3-hydroxy-N,N,5-trimethylpyrazole-1-carboxamide; 2-...
Literature References: Prepn: T. Grauer, H. Urwyler, US 3452043 (1969 to Geigy). Toxicity data: E. F. Edson, Pharm. J. 185, 361 (1960). Insecticidal activity: B. H. Wilson, J. Econ. Entomol. 61, 1764 (1968). Persistence in water: O. M. Aly et al., Water Res. 5, 1191 (1971). HPLC determn: G. Blaicher et al., Chromatographia 13, 438 (1980).

Diperodon Hydrochloride CAS Registry Number: 537-12-2 地哌冬盐酸盐

CAS Name: 3-(1-Piperidinyl)-1,2-propanediol bis(phenylcarbamate) (ester) monohydrochloride
Additional Names: 3-piperidino-1,2-propanediol dicarbanilate hydrochloride; 3-(1-piperidyl)-1,2-propan...
Literature References: Prepn: T. H. Rider, J. Am. Chem. Soc. 52, 2115 (1930); idem, US 2004132 (1935). Stability of solns: E. S. Cook, T. H. Rider, J. Am. Pharm. Assoc. 26, 222 (1937). Pharmacology: eidem, J. Pharmacol. 64, 1 (1938). X-ray crystallographic study: R. C. Sullivan, K. P. O'Brien, Bull. Narc. 20, 31 (1968). IR spectra: eidem, ibid. 22, 35 (1970).

Homidium CAS Registry Number: 3546-21-2 5-乙基-6-苯基菲啶-5-鎓-3,8-二胺

CAS Name: 3,8-Diamino-5-ethyl-6-phenylphenanthridinium
Additional Names: 2,7-diamino-9-phenyl-10-ethylphenanthridinium; 2,7-diamino-10-ethyl-9-phenylphenanthridinium; ethidiumTrademarks: Novidi...
Literature References: Prepn: T. I. Watkins, J. Chem. Soc. 1952, 3059; Short et al., US 2662082 (1953 to Boots Pure Drug). uv spectrum: B. Hudson, R. Jacobs, Biopolymers 14, 1309 (1975). Inhibition of DNA synthesis: B. A. Newton, J. Gen. Microbiol. 17, 718 (1957); of DNA polymerase: W. H. Elliott, Biochem. J. 86, 562 (1963). Intercalcation of double-stranded DNA: M. J. Waring, J. Mol. Biol. 13, 269 (1965); J.-B. LePecq, C. Paoletti, ibid. 27, 87 (1967). Mutagenicity studies: J. T. MacGregor, I. J. Johnson, Mutat. Res. 48, 103 (1977); G. S. Probst et al., Environ. Mutagen. 3, 11 (1981). Review of interactions with nucleic acids: J.-B. LePecq in Methods of Biochemical Analysis vol. 20, D. Glick, Ed. (Wiley-Interscience, New York, 1971) pp 41-86; M. Waring in Antibiotics vol. 3, J. W. Corcoran, F. E. Hahn, Eds. (Springer-Verlag, New York, 1975) pp 141-165.

Trepibutone CAS Registry Number: 41826-92-0 曲匹布通

CAS Name: 2,4,5-Triethoxy-g-oxobenzenebutanoic acid
Additional Names: 3-(2,4,5-triethoxybenzoyl)propionic acidTrademarks: Supacal (Lederle)
Percent Composition: C 61.92%, H 7.15%, O 30.93%
Literature References: Prepn: T. Murata et al., DE 2244324 corresp to US 3943169 (1973, 1976 both to Takeda). Properties and stabilities: M. Mitani et al., Takeda Kenkyushoho 36, 206 (1977), C.A. 88, 126284f (1978). Pharmacokinetics: eidem, ibid. 215, C.A. 88, 115067m (1978). Biotransformation: T. Kobayashi et al., Xenobiotica 8, 535 (1978). Metabolism studies: S. Tanayama et al., ibid. 365, 377. Spasmolytic action in dogs: H. Satoh et al., Eur. J. Pharmacol. 48, 309 (1978). Mechanism of choleretic action: eidem, ibid. 125. Toxicity studies: S. Sato et al., Takeda Kenkyushoho 36, 263 (1977), C.A. 88, 11535x (1978).

Penicillamine Cysteine Disulfide CAS Registry Number: 18840-45-4 青霉胺半胱氨酸二硫醚

CAS Name: 3-[[(2R)-2-Amino-2-carboxyethyl]dithio]-D-valine
Additional Names: 3,3-dimethyl-3-3'-dithiodialanine; 1,6-diamino-5-5-dimethyl-3,4-dithiahexane-1,6-dicarboxylic acid
Percent Compos...
Literature References: Prepn: Tabachnick et al., Nature 174, 701 (1954); Schöberl et al., Angew. Chem. 68, 213 (1956); Schöberl, Grafje, Ann. 617, 71 (1958); Levine, Nature 187, 940 (1960).