Phenformin CAS Registry Number: 114-86-3 N-苯乙基双胍

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Literature References: Prepn: Shapiro et al., J. Am. Chem. Soc. 81, 2220 (1959); Shapiro, Freedman, US 2961377; US 3057780 (1960, 1962 both to U.S.V.). Metabolism: R. Beckmann, Diabetologia 3, 368 (1967). Association with lactic acidosis in diabetic patients: R. I. Misbin, Ann. Intern. Med. 87, 591 (1977). Toxicity study: G. Proske et al., Arzneim.-Forsch. 12, 314 (1962). Comprehensive description: J. E. Moody, Anal. Profiles Drug Subs. 4, 319-332 (1975). Review of phenformin-induced lactic acidosis: M. E. McGuinness, R. L. Talbert, Ann. Pharmacother. 27, 1183-1187 (1993).