其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Amantanium Bromide CAS Registry Number: 58158-77-3 金刚溴铵

CAS Name: N,N-Dimethyl-N-[2-[(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)oxy]ethyl]-1-decanaminium bromide
Additional Names: 2-(1'-adamantanecarbonyloxy)ethyldimethyldecylammonium bromide; decyl(2-hy...
Literature References: Prepn: R. A. Bauman, US 3928411 (1975 to Colgate-Palmolive); and activity: L. Rovati et al., US 4288609 (1981 to Rotta).

Guanethidine CAS Registry Number: 55-65-2 依斯美林

CAS Name: [2-(Hexahydro-1(2H)-azocinyl)ethyl]guanidine
Additional Names: [2-(octahydro-1-azocinyl)ethyl]guanidine; 1-(2-guanidinoethyl)octahydroazocine; 2-(1'-azacyclooctyl)ethylguanidine; N-(2...
Literature References: Prepn: R. A. Maxwell et al., Experientia 15, 267 (1959); R. P. Mull, US 2928829 (1960 to Ciba). Pharmacology: H. J. Sah et al., Arzneim.-Forsch. 16, 53 (1966). Clinical trial in hypertension: E. A. Ramirez et al., Circulation 55, 519 (1977); in glaucoma: R. A. Hitchings, D. Glover, Br. J. Ophthalmol. 66, 247 (1982).

Lonazolac CAS Registry Number: 53808-88-1 [3-(4-氯苯基)-1-苯基-1H-吡唑-4-基]乙酸

CAS Name: 3-(4-Chlorophenyl)-1-phenyl-1H-pyrazole-4-acetic acid
Percent Composition: C 65.29%, H 4.19%, Cl 11.34%, N 8.96%, O 10.23%
Literature References: Prepn: R. A. Newberry, GB 1373212 (1974 to Wyeth), C.A. 82, 72987t (1975); G. Rainer, US 4146721 (1979 to Byk Gulden); G. Rainer et al., Arzneim.-Forsch. 31, 649 (1981). Pharmacology: R. Riedel, ibid. 655. Clinical studies: G. Lonauer et al., Z. Rheumatol. 40, 161 (1981); W. Siegmeth, P. Placheta, Wien. Klin. Wochenschr. 94, 145 (1982).

Sabeluzole CAS Registry Number: 104383-17-7 噻苯芦索

CAS Name: 4-(2-Benzothiazolylmethylamino)-a-[(4-fluorophenoxy)methyl]-1-piperidineethanol
Additional Names: N-methyl-N-[1-[3-(4-fluorophenoxy)-2-hydroxypropyl]piperidin-4-yl]benzothiazole-2-ami...
Literature References: Prepn: R. A. Stokbroekx et al., EP 184257 (1986 to Janssen). Pharmacology: A. Wauquier et al., Drug Dev. Res. 8, 373 (1986). Comparative activity of racemate and enantiomers: L. Werbrouck et al., ibid. 24, 41 (1991). Clinical pharmacokinetics: P. P. DeDeyn et al., Eur. J. Clin. Pharmacol. 43, 661 (1992). Clinical evaluation of effects on memory functions: G. H. C. Clincke et al., Psychopharmacology 94, 52 (1988). Clinical studies in age-associated memory impairment: L. Tritsmans et al., Drug Dev. Res. 20, 473 (1990); G. Clincke et al., ibid. 23, 301 (1991); in memory functions of epileptics: A. P. Aldenkamp et al., Neuropsychobiology 32, 37 (1995).

Cyclizine CAS Registry Number: 82-92-8 1-二苯甲基-4-甲基哌嗪

CAS Name: 1-Diphenylmethyl-4-methylpiperazine
Additional Names: N-benzhydryl-N'-methylpiperazine; N-methyl-N'-benzhydrylpiperazine; (N-benzhydryl)(N'-methyl)diethylenediamineTrademarks: Marzine...
Literature References: Prepn: R. Baltzly et al., J. Org. Chem. 14, 775 (1949); eidem, US 2630435 (1953 to Burroughs Wellcome). Metabolism: R. Kuntzman et al., Ann. N.Y. Acad. Sci. 226, 131 (1973). Physical properties and analysis: S. A. Benezra, Anal. Profiles Drug Subs. 6, 83 (1977). Crystallographic study: V. Bertolasi et al., Acta Crystallogr. B36, 1975 (1980). HPLC determn: R. B. Walker, I. Kanfer, J. Chromatogr. B 672, 172 (1995). Clinical antiemetic efficacy: G. Rowlands, W. J. Currie, Br. J. Clin. Pract. 30, 197 (1976); W. N. Chestnutt et al., Eur. J. Anaesthesiol. 3, 27 (1986).

Sertaconazole CAS Registry Number: 99592-32-2 舍他康唑

CAS Name: 1-[2-[(7-Chlorobenzo[b]thien-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
Additional Names: (±)-1-[2,4-dichloro-b-[(7-chlorobenzo[b]thien-3-yl)methoxy]phenethyl]imidaz...
Literature References: Prepn: R. Foguet et al., EP 151477; eidem, US 5135943 (1985, 1992 both to Ferrer). Synthesis, antifungal activity, pharmacology, toxicology and clinical evaluations: Arzneimittel-Forsch. 42, 689-774 (1992). Physical props: C. Albet et al., ibid. 695. HPLC determn: eidem, J. Pharm. Biomed. Anal. 10, 205 (1992).

Sulfathiazole CAS Registry Number: 72-14-0 磺胺噻唑

CAS Name: 4-Amino-N-2-thiazolylbenzenesulfonamide
Additional Names: N1-2-thiazolylsulfanilamide; 2-sulfanilamidothiazole; 2-(sulfanilylamino)thiazole; 2-(p-aminobenzenesulfonamido)thiazole; nor...
Literature References: Prepn: R. J. Fosbinder, L. A. Walter, J. Am. Chem. Soc. 61, 2032 (1939); W. A. Lott, F. H. Bergeim, ibid. 3593; G. Newbery, P. Viaud, GB 517272; G. Newbery, US 2362087 (1940, 1944 both to May Baker). Antibacterial activity in vivo: O. W. Barlow, E. Homburger, Proc. Soc. Exp. Biol. Med. 42, 792 (1939). Toxicology: H. B. van Dyke et al., ibid. 410; P. H. Long et al., ibid. 43, 328 (1940). Review of early literature: ACS Monograph Series no. 106, entitled "Sulfonamides and Allied Compounds," E. H. Northey, Ed. (Reinhold, New York, 1948) 660 pp. HPLC determn in milk: V. K. Agarwal, J. Liq. Chromatogr. 16, 3793 (1993). Oral bioavailability in ruminants: K. Weijkamp et al., Vet. Q. 16, 33 (1994). Comprehensive description: V. K. Kapoor, Anal. Profiles Drug Subs. Excip. 22, 389-430 (1993).

Albendazole CAS Registry Number: 54965-21-8 阿苯达唑

CAS Name: [5-(Propylthio)-1H-benzimidazol-2-yl]carbamic acid methyl ester
Additional Names: methyl 5-(propylthio)-2-benzimidazolecarbamate; 5-(propylthio)-2-carbomethoxyaminobenzimidazoleTradem...
Literature References: Prepn: R. J. Gyurik, V. J. Theodorides, US 3915986 (1975 to SmithKline). Anthelmintic spectrum: V. J. Theodorides, Experientia 32, 702 (1976). Metabolism: R. J. Gyurik et al., Drug Metab. Dispos. 9, 503 (1981). Efficacy in cattle vs gastrointestinal parasites: J. C. Williams et al., Am. J. Vet. Res. 38, 2037 (1977); vs liver flukes: T. M. Craig et al., ibid. 53, 1170 (1992). Clinical trial in mixed helminth infections: P. Pene et al., Am. J. Trop. Med. Hyg. 31, 263 (1982); in echinococcosis: R. J. Horton, Trans. R. Soc. Trop. Med. Hyg. 83, 97 (1989).

Butyl Isocyanate CAS Registry Number: 111-36-4 异氰酸正丁酯

CAS Name: 1-Isocyanatobutane
Additional Names: isocyanic acid butyl ester; n-butyl isocyanate; BIC
Percent Composition: C 60.58%, H 9.15%, N 14.13%, O 16.14%
Literature References: Prepn: R. J. Slocombe et al., J. Am. Chem. Soc. 72, 1888 (1950); T. I. Bieber, ibid. 74, 4700 (1952); E. T. Shawl et al., EP 408277 (1991 to Arco). Toxicity study: J. Pauluhn, A. Eben, Arch. Toxicol. 66, 118 (1992). Analytical methods development: R. J. Rando et al., J. Liq. Chromatogr. 16, 3977 (1993).

Desoximetasone CAS Registry Number: 382-67-2 去羟米松

CAS Name: (11b,16a)-9-Fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
Additional Names: 9a-fluoro-16a-methyl-17-desoxyprednisolone; 9a-fluoro-16a-methyl-D1-corticosterone; desoxymet...
Literature References: Prepn: R. Joly et al., FR 1296544; eidem, US 3099654 (1962, 1963 to Roussel-UCLAF); BE 614196; Kieslich et al., US 3232839 (1962, 1966 to Schering AG); R. Joly et al., Arzneim.-Forsch. 24, 1 (1974). Activity studies: Branceni et al., Steroids 6, 451 (1965); Schröder et al., Arzneim.-Forsch. 24, 3 (1974). NMR data: Lukacs et al., C.R. Seances Acad. Sci. Ser. C 274, 1458 (1972). Review of pharmacology and therapeutic efficacy in dermatoses: R. C. Heel et al., Drugs 16, 302-321 (1978).