其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Dodecamethylpentasiloxane CAS Registry Number: 141-63-9 十二甲基五硅氧烷

Percent Composition: C 37.45%, H 9.43%, O 16.63%, Si 36.49%
Literature References: Prepn: Patnode, Wilcock, J. Am. Chem. Soc. 68, 358 (1946).

Paroxypropione CAS Registry Number: 70-70-2 4-羟基苯丙酮; 对羟基苯丙酮

CAS Name: 1-(4-Hydroxyphenyl)-1-propanone
Additional Names: 4'-hydroxypropiophenone; p-hydroxypropiophenone; paraoxypropiophenone; p-propionylphenol; ethyl p-hydroxyphenyl ketone; P.O.P.Tradema...
Literature References: Prepn: Perkin, J. Chem. Soc. 55, 546 (1889); Goldzweig, Kaiser, J. Prakt. Chem. [2] 43, 86 (1891); Cox, J. Am. Chem. Soc. 49, 1028 (1927); Hartung et al., ibid. 53, 4153 (1931); Farinholt, ibid. 55, 3386 (1933); Miller, Hartung, Org. Synth. coll. vol. II (1943) p 543. Derivatives: Buu-Hoi, Rec. Trav. Chim. 68, 759 (1949).

N,N-1-Trimethyl-3,3-diphenylpropylamine CAS Registry Number: 13957-55-6 N,N-二甲基-4,4-二苯基-2-丁胺

CAS Name: N,N,a-Trimethyl-g-phenylbenzenepropanamine
Additional Names: 4,4-diphenyl-2-dimethylaminobutane; 3-dimethylamino-1,1-diphenylbutane
Trademarks: Recipavrin (Recip)
Percent Compos...
Literature References: Prepn: Perrine, J. Org. Chem. 18, 898 (1953).

Barium Dithionate CAS Registry Number: 13845-17-5

Additional Names: Barium hyposulfate
Percent Composition: Ba 46.17%, O 32.27%, S 21.56%
Literature References: Prepn: Pfanstiel, Inorg. Synth. 2, 170 (1946).

Dichloralphenazone CAS Registry Number: 480-30-8

CAS Name: 1,2-Dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one compd with 2,2,2-trichloro-1,1-ethanediol(1:2)
Additional Names: dichloralantipyrine
Trademarks: Bonadorm (Smith Nephew); Dormwe...
Literature References: Prepn: Pfeiffer, Seidel, Z. Physiol. Chem. 178, 97 (1928). GLC determn in pharmaceutical formulation: F. M. Plakogiannis, A. M. Saad, J. Pharm. Sci. 66, 604 (1977). Clinical trial of combination with isometheptene and acetaminophen, q.q.v., in treatment of migraine: S. Diamond, Headache 15, 282 (1976).

Stilbazium Iodide CAS Registry Number: 3784-99-4 司替碘铵

CAS Name: 1-Ethyl-2,6-bis[2-[4-(1-pyrrolidinyl)phenyl]ethenyl]pyridinium iodide
Additional Names: 1-ethyl-2,6-bis[p-(1-pyrrolidinyl)styryl]pyridinium iodide; 2,6-bis(p-1-pyrrolidinylstyryl)-1-e...
Literature References: Prepn: Phillips, Burrows, US 3085935 (1963 to Burroughs Wellcome). Toxicity data: R. B. Burrows, Prog. Drug Res. 17, 110 (1973).

Chloropyramine CAS Registry Number: 59-32-5 氯吡拉敏

CAS Name: N-[(4-Chlorophenyl)methyl]-N',N'-dimethyl-N-2-pyridinyl-1,2-ethanediamine
Additional Names: 2-[(p-chlorobenzyl)[2-(dimethylamino)ethyl]amino]pyridine; N-dimethylaminoethyl-N-p-chlorob...
Literature References: Prepn: Phillips, Cates, US 2607778 (1952 to Merck Co.); Howard, US 2569314 (1951 to Am. Cyanamid); CH 264754; CH 266234; CH 266235 (1950); GB 651596 (1951) (all to Geigy).

Hydrocortamate CAS Registry Number: 76-47-1 氢可他酯

CAS Name: N,N-Diethylglycine (11b)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl ester
Additional Names: cortisol 21-ester with N,N-diethylglycine; cortisol 21-(N,N-diethyl)glycinate; hydrocortiso...
Literature References: Prepn: Pinson, Laubach, DE 1016708 (1957 to Pfizer), C.A. 54, 22737a (1960); Richter, Schenck, DE 1037451 (1958 to Schering AG), C.A. 54, 22730h (1960).

Metrizoic Acid CAS Registry Number: 1949-45-7 甲泛影酸

CAS Name: 3-(Acetylamino)-5-(acetylmethylamino)-2,4,6-triiodobenzoic acid
Additional Names: 3-acetamido-2,4,6-triiodo-5-(N-methylacetamido)benzoic acid; N-methyl-3,5-diacetamido-2,4,6-triiodobe...
Literature References: Prepn: Pitré, Fumigalli, Farmaco Ed. Sci. 17, 340 (1962); GB 973881 (1964 to Nyegaard), C.A. 62, 16139g (1965). Series of articles on use in separation of leukocytes from blood and bone marrow: A. Boyum, Scand. J. Clin. Lab. Invest. 21, Suppl. 97, 7-106 (1968).

Levopropoxyphene CAS Registry Number: 2338-37-6 左丙氧芬

CAS Name: (aR)-a-[(1S)-2-(Dimethylamino)-1-methylethyl]-a-phenylbenzeneethanol propanoate (ester)
Additional Names: a-l-4-dimethylamino-3-methyl-1,2-diphenyl-2-butanol propionate; a-l-4-dimethy...
Literature References: Prepn: Pohland, Sullivan, J. Am. Chem. Soc. 77, 3400 (1955). Stereoselective synthesis: Pohland et al., J. Org. Chem. 28, 2483 (1963). Toxicity data: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971). See also Propoxyphene.