其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Mephenesin CAS Registry Number: 59-47-2 3-(2-甲基苯氧基)-1,2-丙烷二醇

CAS Name: 3-(2-Methylphenoxy)-1,2-propanediol
Additional Names: 3-(o-tolyloxy)-1,2-propanediol; 1,2-dihydroxy-3-(2-methylphenoxy)propane; a-(o-tolyl)glyceryl ether; glyceryl o-tolyl ether; o-cr...
Literature References: Prepn: P. Morch, Arch. Pharm. Chemi 54, 327 (1947), C.A. 42, 2058 (1948); GB 589821 (1947 to Carroll and Boake Roberts); of the carbamate: W. A. Lott, E. Pribyl, US 2609386 (1952 to Squibb). Pharmacology: F. M. Berger, W. Bradley, Br. J. Pharmacol. 1, 265 (1946); and toxicity data: P. E. Dresel, I. H. Slater, Proc. Soc. Exp. Biol. Med. 79, 286 (1952); A. P. Roszkowski, J. Pharmacol. Exp. Ther. 129, 75 (1960).

Diloxanide CAS Registry Number: 579-38-4 二氯尼特

CAS Name: 2,2-Dichloro-N-(4-hydroxyphenyl)-N-methylacetamide
Additional Names: 2,2-dichloro-4'-hydroxy-N-methylacetanilide; N-dichloroacet-4-hydroxy-N-methylanilide; 4-hydroxy-N-methyldichloroa...
Literature References: Prepn: P. Oxley et al., US 2912438 (1959 to Boots Pure Drug). Spectrophotometric determn in 2-component tablet formulation: S. M. Galal et al., J. Pharm. Belg. 46, 315 (1991). Clinical trial of combination with metronidazole, q.v., in amoebiasis and giardiasis: H. Qureshi et al., J. Int. Med. Res. 25, 167 (1997). Review of clinical experience: J. B. McAuley et al., Clin. Infect. Dis. 15, 464-468 (1992).

Bumetanide CAS Registry Number: 28395-03-1 布美他尼

CAS Name: 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid
Additional Names: 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acidTrademarks: Bumex (Roche); Burinex (Leo Pharm); Butinat (Gramo...
Literature References: Prepn: P. W. Feit, DE 1964503 and DE 1964504; idem, US 3806534 (1970, 1970, 1974 all to Lövens Kemiske Fabrik); idem, J. Med. Chem. 14, 432 (1971). Pharmacology: E. H. Oestergaard et al., Arzneim.-Forsch. 22, 66 (1972). HPLC and GC/MS determn in urine: C. Y. Gradeen et al., J. Anal. Toxicol. 14, 123 (1990). Review of pharmacology and therapeutic use: A. Ward, R. C. Heel, Drugs 28, 426-464 (1984). Series of articles on pharmacokinetics and comparative clinical studies in combination therapy: Curr. Ther. Res. 50, Suppl. A, 1-82 (1991). Comprehensive description: P. N. V. Tata et al., Anal. Profiles Drug Subs. Excip. 22, 107-144 (1993).

Methallibure CAS Registry Number: 926-93-2 3-(丁-3-烯-2-基)-1-[(甲基氨基甲硫酰基)氨基]硫脲

CAS Name: N-Methyl-N'-(1-methyl-2-propenyl)-1,2-hydrazinedicarbothioamide
Additional Names: 1-methyl-6-(1-methylallyl)-2,5-dithiobiurea; N-methylthiocarbamoyl-N'-[(1-methylallyl)thiocarbamoyl]h...
Literature References: Prepn: Paget et al., GB 878177 (1961 to I.C.I.). Inhibition of pituitary gonadotropic function in animals: Paget et al., Nature 192, 1191 (1961). Prevention of fetus nidation when given orally to rats: Harper, J. Reprod. Fertil. 7, 211 (1964).

Picosulfate Sodium CAS Registry Number: 10040-45-6 匹可硫酸钠

CAS Name: 4,4'-(2-Pyridinylmethylene)bisphenol bis(hydrogen sulfate) (ester) disodium salt
Additional Names: 4,4'-(2-pyridylmethylene)diphenolbis(hydrogen sulfate) (ester) disodium salt; 4,4'-(...
Literature References: Prepn: Pala, FR M5832 and US 3528986, US 3558643 (1968, 1970, 1971 all to Ist. de Angeli); Seeger, Machleidt, DE 1904322 (1970 to Thomae). Synthesis and physical-chemical data: Pala et al., Helv. Chim. Acta 51, 1164 (1968). Pharmacology: Pala et al., Arch. Int. Pharmacodyn. Ther. 164, 356 (1966). Metabolism: Perego et al., Arzneim.-Forsch. 19, 1889 (1969).

Bencyclane CAS Registry Number: 2179-37-5 平痉可宁

CAS Name: N,N-Dimethyl-3-[[1-(phenylmethyl)cycloheptyl]oxy]-1-propanamine
Additional Names: 3-[(1-benzylcycloheptyl)oxy]-N,N-dimethylpropylamine; 1-benzyl-1-(3-dimethylaminopropoxy)cycloheptane...
Literature References: Prepn: Pallos et al., HU 151865 (1965 to EGYT), C.A. 62, 16125b (1965). Series of articles on pharmacology: Arzneim.-Forsch. 20, 1337-1460 (1970). Toxicity: E. Komlos, L. E. Petöcz, ibid. 1338.

Iophenoxic Acid CAS Registry Number: 96-84-4 α-乙基-3-羟基-2,4,6-三碘氢化肉桂酸

CAS Name: a-Ethyl-3-hydroxy-2,4,6-triiodobenzenepropanoic acid
Additional Names: a-ethyl-3-hydroxy-2,4,6-triiodohydrocinnamic acid; a-(2,4,6-triiodo-3-hydroxybenzyl)butyric acid; a-ethyl-b-(3-h...
Literature References: Prepn: Papa et al., J. Am. Chem. Soc. 75, 1107 (1953); GB 726987 (1955 to Sterling Drug). Toxicity data: J. O. Hoppe et al., J. Med. Chem. 13, 997 (1970).

Amisometradine CAS Registry Number: 550-28-7 阿米美啶

CAS Name: 6-Amino-3-methyl-1-(2-methyl-2-propenyl)-2,4(1H,3H)-pyrimidinedione
Additional Names: 6-amino-3-methyl-1-(2-methylallyl)uracil; 1-methallyl-3-methyl-6-aminotetrahydro-2,4-pyrimidinedi...
Literature References: Prepn: Papesch, Schroeder, US 2729669 (1956 to Searle).