其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Albutoin CAS Registry Number: 830-89-7 阿布妥因

CAS Name: 5-(2-Methylpropyl)-3-(2-propenyl)-2-thioxo-4-imidazolidinone
Additional Names: 3-allyl-5-isobutyl-2-thiohydantoin; 3-allyl-5-sec-butyl-2-thiohydantoin
Trademarks: CO-ORD (Baxter); ...
Literature References: Prepn: Oba et al., C.A. 46, 3885f (1952).

e -Acetamidocaproic Acid CAS Registry Number: 57-08-9 6-乙酰氨基己酸

CAS Name: 6-(Acetylamino)hexanoic acid
Additional Names: 6-acetamidohexanoic acid; acetaminocaproic acid; acexamic acid; N-acetyl-6-aminohexanoic acid
Percent Composition: C 55.47%, H 8.73%,...
Literature References: Prepn: Offe, Z. Naturforsch. 2b, 182 (1947); FR M2332 (1964 to Rowa), C.A. 61, 577b (1964). Anti-inflammatory activity of salts: O. Guillard et al., Pharmacology 34, 296 (1987). Clinical comparison with ranitidine in gastroduodenal ulcer: M. J. Varas Lorenzo, Curr. Ther. Res. 39, 19 (1986).

Hemisulfur Mustard CAS Registry Number: 693-30-1 2-羟基乙基 2-氯乙基硫醚

CAS Name: 2-(2-Chloroethylthio)ethanol
Additional Names: 2-chloro-2'-hydroxydiethyl sulfide; 2-chloroethyl 2-hydroxyethyl sulfide; b-chloroethyl b-hydroxyethyl thioether; mustard chlorohydrin; ...
Literature References: Prepn: Ogston et al., Trans. Faraday Soc. 44, 45 (1948); Grant, Kinsey, J. Am. Chem. Soc. 68, 2075 (1946); Fuson, Ziegler, J. Org. Chem. 11, 510 (1946); Rueggeberg et al., ibid. 13, 110 (1948); Tsou et al., ibid. 26, 4987 (1961).

Octotiamine CAS Registry Number: 137-86-0 硫辛酸硫胺

CAS Name: 6-(Acetylthio)-8-[[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-(2-hydroxyethyl)-1-propenyl]dithio]octanoic acid methyl ester
Additional Names: 8-[[2-[N-[(4-amino-2-methy...
Literature References: Prepn: Ohara et al., US 3098856 (1963 to Fujisawa).

Chlorthenoxazin(e) CAS Registry Number: 132-89-8 氯西诺嗪

CAS Name: 2-(2-Chloroethyl)-2,3-dihydro-4H-1,3-benzoxazin-4-one
Additional Names: 2-(b-chloroethyl)-2,3-dihydro-4-oxo-(benzo-1,3-oxazine); 4-oxo-2-(b-chloroethyl)-2,3-dihydrobenzo-1,3-oxazine; ...
Literature References: Prepn: Ohnacker, US 2943087 (1960 to Thomae).

Clofenamide CAS Registry Number: 671-95-4 氯非那胺

CAS Name: 4-Chloro-1,3-benzenedisulfonamide
Additional Names: 4-chloro-m-benzenedisulfonamide; 1-chlorobenzene-2,4-disulfonamide; chlorphenamide; monochlorphenamide
Trademarks: Salco; Saltro...
Literature References: Prepn: Olivier, Rec. Trav. Chim. 37, 307 (1918); Davies, Wood, J. Chem. Soc. 1928, 1125.

Calcium Ferrous Citrate CAS Registry Number: 53684-61-0

Additional Names: Ferrous calcium citrate
Trademarks: Ferrocal; Rarical (Ortho)
Percent Composition: C 28.03%, H 1.96%, Ca 15.59%, Fe 10.86%, O 43.56%
Literature References: Prepn: Opfermann, US 2691666 (1954); Oroshnik, US 2812344 (1956 to Ortho Pharm.).

Actinoquinol CAS Registry Number: 15301-40-3 8-乙氧基喹啉-5-磺酸水合物

CAS Name: 8-Ethoxy-5-quinolinesulfonic acid
Percent Composition: C 52.16%, H 4.38%, N 5.53%, O 25.27%, S 12.66%
Literature References: Prepn: Orlov, Bogdanov, J. Appl. Chem. USSR 5, 803 (1932), C.A. 27, 7248 (1933); Ghosh, Roy, J. Indian Chem. Soc. 22, 39 (1945); Dorier et al., Trav. Soc. Pharm. Montpellier 14(3), 152 (1954), C.A. 50, 1011a (1956).

Metron S CAS Registry Number: 13946-02-6 异丙海汀

CAS Name: 6-Methyl-N-(1-methylethyl)-2-heptanamine
Additional Names: N-isopropyl-1,5-dimethylhexylamine; 2-isopropylamino-6-methylheptane
Trademarks: Metron (Japanese)
Percent Composition...
Literature References: Prepn: Ota et al., Yakugaku Zasshi 80, 1153 (1960), C.A. 55, 3825d (1961).

Haloperidol CAS Registry Number: 52-86-8 氟哌啶醇

CAS Name: 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone
Additional Names: 4-[4-(p-chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone; 4'-fluoro-4-(4-hydrox...
Literature References: Prepn: P. A. J. Janssen et al., J. Med. Pharm. Chem. 1, 281 (1959); P. A. J. Janssen, BE 577977 (1959), C.A. 54, 4630c (1960); idem, GB 895309; idem, US 3438991 (1962, 1969 both to Janssen). Toxicity: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971); A. J. Collins, M. Horlington, Br. J. Pharmacol. 37, 140 (1969). Metabolism in man: A. Forsman et al., Curr. Ther. Res. 21, 606 (1977). Comprehensive description: C. A. Janicki, C. Y. Ko, Anal. Profiles Drug Subs. 9, 341-369 (1980). Review of pharmacology and therapeutic efficacy of decanoate in psychosis: R. Beresford, A. Ward, Drugs 33, 31-49 (1987).