其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Phosphoserine CAS Registry Number: 407-41-0 L-O-磷酸丝氨酸

CAS Name: Serine dihydrogen phosphate (ester)
Additional Names: serine phosphate; O-phospho-DL-serine
Percent Composition: C 19.47%, H 4.36%, N 7.57%, O 51.87%, P 16.74%
Literature References: Prepn: Neuhaus, Korkes, Biochem. Prep. 6, 75 (1958); D. M. Theodoropoulos, J. Chem. Soc. 1960, 5257. Other methods of prepn and isoln from protein hydrolysates: Greenstein, Winitz, Chemistry of the Amino Acids (Wiley, New York, 1961), passim. Crystal structure: G. H. McCallum, Nature 184, 1863 (1959).

Allylurea CAS Registry Number: 557-11-9 烯丙基脲

CAS Name: N-2-Propenylurea
Additional Names: allylcarbamide
Percent Composition: C 47.99%, H 8.05%, N 27.98%, O 15.98%
Literature References: Prepn: Neville, McGee, Can. J. Chem. 41, 2123 (1963).

n-Butyl Benzoate CAS Registry Number: 136-60-7 苯甲酸丁酯

CAS Name: Benzoic acid butyl ester
Percent Composition: C 74.13%, H 7.92%, O 17.95%
Literature References: Prepn: Newman, Fones, J. Am. Chem. Soc. 69, 1046 (1947); Justoni, GB 719891 (1954 to Vismara). Toxicity study: H. F. Smyth et al., Arch. Ind. Hyg. Occup. Med. 10, 61 (1954).

Croceic Acid CAS Registry Number: 132-57-0 7-羟基萘-1-磺酸

CAS Name: 7-Hydroxy-1-naphthalenesulfonic acid
Additional Names: 2-naphthol-8-sulfonic acid; Bayer's acid
Percent Composition: C 53.56%, H 3.60%, O 28.54%, S 14.30%
Literature References: Prepn: Nietzki, Zübelen, Ber. 22, 453 (1889); Forster, Keyworth, J. Soc. Chem. Ind. London 46, 26T (1927).

Atropic Acid CAS Registry Number: 492-38-6 2-苯基丙烯酸

CAS Name: a-Methylenebenzeneacetic acid
Additional Names: a-phenylacrylic acid
Percent Composition: C 72.96%, H 5.44%, O 21.60%
Literature References: Prepn: Normant, Maitte, Bull. Soc. Chim. Fr. 1956, 1439.

Tetrantoin CAS Registry Number: 52094-70-9 替群妥英

CAS Name: 3',4'-Dihydrospiro[imidazolidine-4,2'(1'H)-naphthalene]-2,5-dione
Additional Names: 7,8-benzo-1,3-diazaspiro[4.5]decane-2,4-dioneTrademarks: Spirodon
Percent Composition: C 66.65%,...
Literature References: Prepn: Novelli, An. Farm. Bioquim. 21, 81 (1954), C.A. 50, 4922 (1956); Faust et al., J. Am. Pharm. Assoc. 46, 118 (1957); Jules et al., US 2716648 (1955 to Cutter Labs.).

Chloraminophenamide CAS Registry Number: 121-30-2 4-氨基-6-氯-1,3-苯二磺酰胺

CAS Name: 4-Amino-6-chloro-1,3-benzenedisulfonamide
Additional Names: 4-amino-6-chloro-m-benzenedisulfonamide; 5-chloro-2,4-bis(sulfonamido)aniline; 6-amino-4-chlorobenzene-1,3-disulfonamide; 5...
Literature References: Prepn: Novello, Sprague, J. Am. Chem. Soc. 79, 2028 (1957); Novello, US 2809194; US 2965655; US 2965656 (1957, 1960, 1960 all to Merck Co.); Novello et al., J. Org. Chem. 25, 965 (1960).

Pyrazinamide CAS Registry Number: 98-96-4 吡嗪酰胺

CAS Name: Pyrazinecarboxamide
Additional Names: pyrazinoic acid amide; pyrazine carboxylamideTrademarks: Pezetamid (Hefa-Frenon); Pyrafat (Fatol); Pirilène (Cassenne); Piraldina (Bracco); Tebra...
Literature References: Prepn: O. Dalmer, E. Walter, DE 632257 (1936 to E. Merck); eidem, US 2149279 (1939 to Merck Co.); S. A. Hall, P. E. Spoerri, J. Am. Chem. Soc. 62, 664 (1940). Structure-activity study: S. Kushner et al., ibid. 74, 3617 (1952). Pharmacology: I. M. Weiner, J. P. Tinker, J. Pharmacol. Exp. Ther. 180, 411 (1972). HPLC determn in biological samples: J. E. Conte, Jr. et al., J. Chromatogr. Sci. 38, 33 (2000). Clinical pharmacokinetics: C. A. Peloquin et al., Pharmacotherapy 18, 1205 (1998). Clinical trial in combination with rifampicin and isoniazid, q.q.v.: S. K. Teo, Int. J. Tuberc. Lung Dis. 3, 126 (1999); in prevention of tuberculosis: F. Gordin et al., J. Am. Med. Assoc. 283, 1445 (2000). Comprehensive description: E. Feldner, D. Pitre, Anal. Profiles Drug Subs. 12, 433-462 (1983). Review of clinical experience: M. A. Steele, R. M. Des Prez, Chest 94, 845-850 (1988).

sym-Dichloroethyl Ether CAS Registry Number: 111-44-4 二氯乙基醚

CAS Name: 1,1'-Oxybis[2-chloroethane]
Additional Names: bis(2-chloroethyl) ether; b,b'-dichloroethyl ether; DCEE
Trademarks: Chlorex
Percent Composition: C 33.59%, H 5.64%, Cl 49.58%, O 1...
Literature References: Prepn: O. Kamm, J. H. Waldo, J. Am. Chem. Soc. 43, 2223 (1921). Toxicity: H. F. Smyth, Jr., C. P. Carpenter, J. Ind. Hyg. Toxicol. 30, 66 (1948). Evaluation of carcinogenic risk: IARC Monographs 9, 117 (1975). Review of toxicology and human exposure: Toxicological Profile for Bis(2-chloroethyl)ether (PB90-168683, 1989) 83 pp.

Hexobendine CAS Registry Number: 54-03-5 海索苯定

CAS Name: 3,4,5-Trimethoxybenzoic acid 1,2-ethanediylbis[(methylimino)-3,1-propanediyl] ester
Additional Names: 3,4,5-trimethoxybenzoic acid diester with 3,3'-[ethylenebis(methylimino)]di-1-pro...
Literature References: Prepn: O. Kraupp, K. Schlögl, AT 231432; eidem, US 3267103 (1964, 1966 both to OSSW). Pharmacology: Rudolph et al., Arzneim.-Forsch. 20, 637 (1970); Kolassa, Pfleger, Biochem. Pharmacol. 20, 490 (1971); H. Rameis et al., Arzneim.-Forsch. 30, 671 (1980).