其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Isoxsuprine CAS Registry Number: 395-28-8 异舒普林

CAS Name: 4-Hydroxy-a-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]benzenemethanol
Additional Names: p-hydroxy-a-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]benzyl alcohol; p-hydroxy-N-(1-methyl-2-phe...
Literature References: Prepn: Moed, van Dijk, Rec. Trav. Chim. 75, 1215 (1956); GB 832286 and GB 832287 (both 1960 to N. V. Philip Gloeilampenfabrieken); Moed, US 3056836 (1962 to N. Am. Philips). Configuration: Dirkx, Rec. Trav. Chim. 83, 535 (1964). Toxicity data: Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971). Clinical evaluation in Raynaud's phenomenon: H. Wesseling et al., Eur. J. Clin. Pharmacol. 20, 329 (1981); in intermittent claudication: S. H. Skotnicki et al., Angiology 35, 685 (1984). Veterinary trial in navicular disease: A. S. Turner, C. M. Tucker, Equine Vet. J. 21, 338 (1989).

Mercamphamide CAS Registry Number: 127-50-4

CAS Name: 3-[[3-(Hydroxymercuri)-2-methoxypropyl]carbamoyl]-1,2,2-trimethylcyclopentanecarboxylic acid
Additional Names: N-[3-(hydroxymercuri)-2-methoxypropyl]camphoramic acid; N-(g-hydroxymerc...
Literature References: Prepn: Molnar, US 2117901 (1938); Werner, Scholz, J. Am. Chem. Soc. 76, 2453 (1954).

Dicobalt Octacarbonyl CAS Registry Number: 10210-68-1 八羰基二钴

CAS Name: Di-m-carbonylhexacarbonyldicobalt
Additional Names: octacarbonyldicobalt; cobalt tetracarbonyl; cobalt octacarbonyl
Percent Composition: C 28.10%, Co 34.47%, O 37.43%
Literature References: Prepn: Mond et al., J. Chem. Soc. 97, 798 (1910); Gilmont, Blanchard, Inorg. Synth. 2, 238 (1946); Wender et al., ibid. 5, 190 (1957); Chini et al., Chim. Ind. (Milan) 55, 120 (1973). Crystal structure: Sumner et al., Acta Crystallogr. 17, 732 (1964). Two isomeric forms exist in soln: Noack, Spectrochim. Acta 19, 1925 (1963); Bor, ibid. 2065; Noack, Helv. Chim. Acta 47, 1064, 1555 (1964). Toxicity studies: Kincaid et al., Arch. Ind. Hyg. Occup. Med. 10, 210 (1954); Brief et al., Arch. Environ. Health 23, 373 (1971); Kalekin, C.A. 78, 67751z (1973); Spiridonova, Shabalina, Gig. Sanit. 1973, 73, C.A. 78, 119835b (1973). Reviews of prepn, properties and chemistry of cobalt carbonyls: I. Wender et al., Bull. U.S. Bur. Mines 600, 83 pp (1960); Organic Syntheses via Metal Carbonyls vol. 1, I. Wender, P. Pino, Eds. (Interscience, New York, 1968) passim; Chalk, Harrod, "Catalysis by Cobalt Carbonyls" in Adv. Organomet. Chem. 6, 119-170 (1968); Nicholls in Comprehensive Inorganic Chemistry vol. 3, J. C. Bailar, Jr. et al., Eds. (Pergamon Press, Oxford, 1973) pp 1059-1064.

Thibenzazoline CAS Registry Number: 6028-35-9 1,3-二(羟基甲基)-1,3-二氢-2H-苯并咪唑-2-硫酮

CAS Name: 1,3-Dihydro-1,3-bis(hydroxymethyl)-2H-benzimidazole-2-thione
Additional Names: 1,3-bis(hydroxymethyl)-2-benzimidazolinethione; 2-mercaptobenzimidazole-1,3-dimethylol
Trademarks: Th...
Literature References: Prepn: Monti, Venturi, Gazz. Chim. Ital. 76, 365 (1946).

Feclemine CAS Registry Number: 3590-16-7 非克立明

CAS Name: 2-(Cyclohexylphenylmethyl)-N,N,N',N'-tetraethyl-1,3-propanediamine
Additional Names: 1,3-bis(diethylamino)-2-(a-phenyl-a-cyclohexylmethyl)propane; 1-phenyl-1-cyclohexyl-2,2-bis(diethy...
Literature References: Prepn: Morren et al., Ind. Chim. Belge 20, 733 (1955); Morren, US 2781398 (1957 to U.C.B.).

Brallobarbital CAS Registry Number: 561-86-4 溴烯比妥

CAS Name: 5-(2-Bromo-2-propenyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
Additional Names: 5-allyl-5-(2-bromoallyl)barbituric acid
Trademarks: Vesperone (UCB)
Percent Composition:...
Literature References: Prepn: Morren, BE 497501 (1950), C.A. 49, 1100e (1955). Metabolism: Keding, Schmidt, Arzneim.-Forsch. 19, 342 (1969).

Clomestrone CAS Registry Number: 4091-75-2 16-alpha-氯-3-甲氧基雌甾-1,3,5(10)-三烯-17-酮

CAS Name: (16a)-16-Chloro-3-methoxyestra-1,3,5(10)-trien-17-one
Additional Names: 16a-chloroestrone 3-methyl ether
Trademarks: Arterolo (Nuovo Cons.); Atheran
Percent Composition: C 71.57...
Literature References: Prepn: Mueller et al., J. Am. Chem. Soc. 80, 1769 (1958); Mueller, US 2855411 (1958 to Searle); Ravizza, CH 343396 (1959). Alternate route: Labs. Sobio, FR 1350100 (1964).

Periodyl CAS Registry Number: 53586-99-5 (9E)-12-羟基-9,10-二碘-9-十八碳烯酸

CAS Name: 12-Hydroxy-9,10-diiodo-9-octadecenoic acid
Additional Names: diiodoricinstearolic acid; ricinstearolic acid diiodide; 8,9-diiodo-11-hydroxy-8-heptadecene-1-carboxylic acid
Trademar...
Literature References: Prepn: Mühle, Ber. 46, 2091 (1913); DE 296495 (to Riedel).

Antipyrine CAS Registry Number: 60-80-0 安替比林

CAS Name: 1,2-Dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one
Additional Names: 2,3-dimethyl-1-phenyl-3-pyrazolin-5-one; phenazone; 1,5-dimethyl-2-phenyl-3-pyrazolone; phenyldimethylpyrazolon(e)...
Literature References: Prepn: Müller et al., Monatsh. Chem. 89, 23 (1958); Hagers Handb. Pharm. Praxis Vol. 6 (Springer Verlag, Berlin, 1977) p 571. Toxicity: Hart, J. Pharmacol. Exp. Ther. 89, 205 (1947). Metabolism: H. Uchino et al., Xenobiotica 13, 155 (1983). Clinical comparison with paracetamol: H. Quiding et al., Int. J. Oral Surg. 11, 304 (1982). Use as indicator of hepatic drug metabolism: E. S. Vessel, Clin. Pharm. Ther. 26, 275 (1979); G. C. Farrell, L. Zaluzny, Br. J. Clin. Pharmacol. 18, 559 (1984). HPLC determn in urine: E. Brendel et al., J. Pharm. Biomed. Anal. 7, 1783 (1989). Clinical pharmacokinetics: H. A. Ali et al., Hum. Exp. Toxicol. 13, 658 (1994).

Tribromoacetic Acid CAS Registry Number: 75-96-7 三溴乙酸

Percent Composition: C 8.10%, H 0.34%, Br 80.78%, O 10.78%
Literature References: Prepn: Müller, US 2057964 (1936 to Winthrop Chem.); A. M. Kovalevskaya, S. A. Shkylar, Zh. Org. Khim. 1, 1540 (1965). Study of far IR spectrum: G. Statz, E. Lippert, Ber. Bunsen-Ges. Phys. Chem. 71, 673 (1967).