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Isoxsuprine CAS Registry Number: 395-28-8 异舒普林

CAS Name: 4-Hydroxy-a-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]benzenemethanol
Additional Names: p-hydroxy-a-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]benzyl alcohol; p-hydroxy-N-(1-methyl-2-phenoxyethyl)norephedrine; 1-(p-hydroxyphenyl)-2-(1-methyl-2-phenoxyethylamino)-1-propanol; 2-(3-phenoxy-2-propylamino)-1-(p-hydroxyphenyl)-1-propanol
Percent Composition: C 71.73%, H 7.69%, N 4.65%, O 15.93%

📌 参考资料/链接：
Literature References: Prepn: Moed, van Dijk, Rec. Trav. Chim. 75, 1215 (1956); GB 832286 and GB 832287 (both 1960 to N. V. Philip Gloeilampenfabrieken); Moed, US 3056836 (1962 to N. Am. Philips). Configuration: Dirkx, Rec. Trav. Chim. 83, 535 (1964). Toxicity data: Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971). Clinical evaluation in Raynaud's phenomenon: H. Wesseling et al., Eur. J. Clin. Pharmacol. 20, 329 (1981); in intermittent claudication: S. H. Skotnicki et al., Angiology 35, 685 (1984). Veterinary trial in navicular disease: A. S. Turner, C. M. Tucker, Equine Vet. J. 21, 338 (1989).

📄 详细内容

Properties: Crystals, mp 102.5-103.5°.
Melting point: mp 102.5-103.5°
Derivative Type: Hydrochloride
CAS Registry Number: 579-56-6
Trademarks: Dilavase (Organon); Duvadilan (Duphar); Duviculine (Duphar); Navilox (Univet); Suprilent (Duphar); Vadosilan (BMS); Vasodilan (BMS); Vasotran (BMS)
Percent Composition: C 63.99%, H 7.16%, N 4.15%, O 14.21%, Cl 10.49%
Properties: Bitter crystals from water, mp 203-204°. Soly in water at 25° about 2.0% w/v; also sol in ethanol. LD50 in rats (mg/kg): 1750 orally; 164 i.p. (Goldenthal).
Melting point: mp 203-204°
Toxicity data: LD50 in rats (mg/kg): 1750 orally; 164 i.p. (Goldenthal)
Therap-Cat: Vasodilator (peripheral).
Therap-Cat-Vet: In treatment of navicular disease.
Keywords: Vasodilator (Peripheral).
产品链接: 395-28-8››

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