其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Dibucaine CAS Registry Number: 85-79-0 辛可卡因

CAS Name: 2-Butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide
Additional Names: 2-butoxy-N-(2-diethylaminoethyl)cinchoninamide; cinchocaine
Percent Composition: C 69.94%, H 8.51%, N 12...
Literature References: Prepn: Miescher, US 1825623 (1931 to Ciba). Comprehensive description: G. R. Padmanabhan, Anal. Profiles Drug Subs. 12, 105-134 (1983). Spectrometric determn in pharmaceutical formulations: N. T. Abdel-Ghani et al., Farmaco 60, 419 (2005).

Drofenine CAS Registry Number: 1679-76-1 alpha-环己基-苯乙酸 2-(二乙基氨基)乙基酯

CAS Name: a-Cyclohexylbenzeneacetic acid 2-(diethylamino)ethyl ester
Additional Names: a-phenylcyclohexaneacetic acid 2-(diethylamino)ethyl ester; 2-diethylaminoethyl a-phenylcyclohexaneacetate...
Literature References: Prepn: Miescher, Hoffman, US 2265184; US 2265185 (both 1941 to Ciba). Pharmacology and toxicity: Fleisch et al., Arzneim.-Forsch. 11, 1119 (1961).

Antazoline CAS Registry Number: 91-75-8 安他唑啉

CAS Name: 4,5-Dihydro-N-phenyl-N-(phenylmethyl)-1H-imidazole-2-methanamine
Additional Names: 2-(N-benzylanilinomethyl)-2-imidazoline; phenazoline; 2-(N-phenyl-N-benzylaminomethyl)imidazoline; i...
Literature References: Prepn: Miescher, Klarer, US 2449241 (1948 to Ciba). HPLC determn in ophthalmic solutions: S. C. Ruckmick et al., J. Pharm. Sci. 84, 502 (1995). Clinical trial in combination with naphazoline in allergic conjunctivitis: M. B. Abelson et al., Arch. Ophthalmol. 108, 520 (1990).

Diphenidol CAS Registry Number: 972-02-1 地芬尼多

CAS Name: a,a-Diphenyl-1-piperidinebutanol
Additional Names: 1,1-diphenyl-4-piperidino-1-butanol; diphenyl-[3-(1-piperidyl)propyl]carbinol; defenidolPercent Composition: C 81.51%, H 8.79%, N 4....
Literature References: Prepn: Miescher, Marxer, US 2411664 (1946 to Ciba); Barrett, Wilkinson, GB 683950 (1952 to Wellcome Foundation), C.A. 48, 2112e (1954). Structure-activity studies: Gautier et al., Med. Pharmacol. Exp. 13, 325 (1965). Clinical studies: Cutt et al., Aerosp. Med. 39, 682 (1968); Benson, ibid. 40, 589 (1969). Acute toxicity: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).

Acranil® (Bayer) CAS Registry Number: 1684-42-0 1-[(6-氯-2-甲氧基吖啶-9-基)氨基]-3-(二乙基氨基)丙烷-2-醇双盐酸盐

CAS Name: 1-[(6-Chloro-2-methoxy-9-acridinyl)amino]-3-(diethylamino)-2-propanol dihydrochloride
Additional Names: 5-[(g-diethylamino-b-hydroxypropyl)amino]-3-methoxy-8-chloroacridine dihydrochl...
Literature References: Prepn: Mietzsch, Mauss, DE 553072 Frdl. 19, 1167; GB 363392; US 2113357 (1930, 1930, 1938 all to I. G. Farben.); Maghidson, Grigorovski, Ber. 69, 396 (1936); J. Gen. Chem. USSR 6, 806 (1936). Antiviral activity: T. E. Gláz et al., Antimicrob. Agents Chemother. 3, 537 (1973). Interferon induction and radioprotective activity: T. E. Glaz, M. Talas, Arch. Virol. 48, 375 (1975); M. Talas, E. Szolgay, ibid. 56, 309 (1978).

Buthalital Sodium CAS Registry Number: 510-90-7 烯丁硫喷妥钠

CAS Name: Dihydro-5-(2-methylpropyl)-5-(2-propenyl)-2-thioxo-4,6(1H,5H)-pyrimidinedione monosodium salt
Additional Names: 5-allyl-5-isobutyl-2-thiobarbituric acid sodium salt; sodium 5-allyl-5-...
Literature References: Prepn: Miller et al., J. Am. Chem. Soc. 58, 1090 (1936). Pharmacology: Schildt, Schildt, Acta Pharmacol. Toxicol. 19, 377 (1962).

Mafenide CAS Registry Number: 138-39-6 磺胺米隆

CAS Name: 4-(Aminomethyl)benzenesulfonamide
Additional Names: a-amino-p-toluenesulfonamide; p-(aminomethyl)benzenesulfonamide; 4-homosulfanilamide; maphenide
Trademarks: Marfanil; Mesudrin; ...
Literature References: Prepn: Miller et al., J. Am. Chem. Soc. 62, 2099 (1940); Klarer, US 2288531 (1942 to Winthrop); Bergeim, Braker, J. Am. Chem. Soc. 66, 1459 (1944); Kusami et al., J. Pharm. Soc. Jpn. 64, no. 9a, 51 (1944); Komokina et al., J. Appl. Chem. (USSR) 21, 681 (1948); Angyal, Jenkin, Aust. J. Sci. Res. 3A, 461 (1950). Toxicity study: T. W. Skulan, J. O. Hoppe, Life Sci. 5, 2279 (1966). Comprehensive description: A. K. Dash, S. Saha, Anal. Profiles Drug Subs. Excip. 24, 277-305 (1996).

Tiopronin CAS Registry Number: 1953-02-2 硫普罗宁

CAS Name: N-(2-Mercapto-1-oxopropyl)glycine
Additional Names: N-(2-mercaptopropionyl)glycine; a-mercaptopropionylglycine
Trademarks: Acadione (Cassenne); Capen (Phoenix); Epatiol (Medici); M...
Literature References: Prepn: Mita et al., US 3246025 (1966 to Santen). Antidotal effects in mice: H. Fujimura et al., Nippon Yakurigaku Zasshi 60, 278 (1964), C.A. 62, 972h (1965). Anti-inflammatory pharmacology in animals: F. Capasso, Agents Actions 11, 741 (1981). Clinical trial in chronic hepatitis: F. Ichida et al., J. Int. Med. Res. 10, 325 (1982). Clinical comparison with D-penicillamine in rheumatoid arthritis: B. Amor et al., Arthritis Rheum. 25, 698 (1982); G. Pasero et al., ibid. 923.

Furonazide CAS Registry Number: 3460-67-1 1''(或2'')-[1-(2-呋喃基)乙基亚烯]尼古丁肼酰胺

CAS Name: 4-Pyridinecarboxylic acid [1-(2-furanyl)ethylidene]hydrazide
Additional Names: isonicotinic acid a-methylfurfurylidenehydrazide; 2-furyl methyl ketone isonicotinoylhydrazone; a-methyl...
Literature References: Prepn: Miyatake et al., J. Pharm. Soc. Jpn. 75, 1066 (1955).

Bietanautine CAS Registry Number: 6888-11-5

CAS Name: 1,2,3,6-Tetrahydro-1,3-dimethyl-2,6-dioxo-7H-purine-7-acetic acid compd with 2-(diphenylmethoxy)-N,N-dimethylethanamine (2:1)
Additional Names: 2-(benzhydryloxy)-N,N-dimethylethylamin...
Literature References: Prepn: Mizier, US 2942000 (1960 to Delagrange).