其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Cyclomethycaine CAS Registry Number: 139-62-8 环美卡因

CAS Name: 4-(Cyclohexyloxy)benzoic acid 3-(2-methyl-1-piperidinyl)propyl ester
Additional Names: p-cyclohexyloxybenzoic acid ester of N-(3-hydroxypropyl)pipecoline; 3-(2-methylpiperidino)propyl...
Literature References: Prepn: McElvain, Carney, J. Am. Chem. Soc. 68, 2592 (1946), eidem, US 2439818 (1948). Toxicity data: Schmidt et al., Toxicol. Appl. Pharmacol. 1, 454 (1959).

Dinitolmide CAS Registry Number: 148-01-6 二硝托胺

CAS Name: 2-Methyl-3,5-dinitrobenzamide
Additional Names: 3,5-dinitro-o-toluamide; 3,5-dinitro-2-methylbenzamide
Trademarks: Zoalene (Dow); Zoamix (Dow)
Percent Composition: C 42.67%, H 3...
Literature References: Prepn: McGookin et al., J. Soc. Chem. Ind. 59, 92 (1940); Harris et al., US 2937204 (1960 to Dow). Activity studies: Peterson, Poult. Sci. 39, 739 (1960); Joyner, Res. Vet. Sci. 1, 363 (1960). Metabolism: Smith et al., J. Agric. Food Chem. 11, 253 (1963); Smith, Anal. Biochem. 7, 461 (1964).

Epithiazide CAS Registry Number: 1764-85-8 依匹噻嗪

CAS Name: 6-Chloro-3,4-dihydro-3-[[(2,2,2-trifluoroethyl)thio]methyl]-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Additional Names: 3-[(2,2,2-trifluoroethylthio)methyl]-6-chloro-3,4-dih...
Literature References: Prepn: McManus, US 3009911 (1961 to Pfizer).

Propatyl Nitrate CAS Registry Number: 2921-92-8 丙帕硝酯

CAS Name: 2-Ethyl-2-[(nitrooxy)methyl]-1,3-propanediol dinitrate (ester)
Additional Names: 2-ethyl-2-(hydroxymethyl)-1,3-propanediol trinitrate; 1,1,1-tris(nitratomethyl)propane; ethyltrimethyl...
Literature References: Prepn: Médard, Mem. Poudres 35, 113 (1953); Bourjol, ibid. 36, 79 (1954); Hensinger, FR 1103113 (1955).

Dianisidine CAS Registry Number: 119-90-4 3,3'-二甲氧基联苯胺

CAS Name: 3,3'-Dimethoxy-[1,1'-biphenyl]-4,4'-diamine
Additional Names: 3,3'-dimethoxybenzidine; 3,3'-dimethoxy-4,4'-diaminobiphenyl
Percent Composition: C 68.83%, H 6.60%, N 11.47%, O 13.10...
Literature References: Prepn: Meier, Böhler, Ber. 89, 2301 (1956); Sogn, US 2794047 (1957 to Allied Chem.). Manuf of stabilized product: Cashion, US 2966519 (1960 to Allied Chem.). Review of carcinogenicity studies: IARC Monographs 4, 41-47 (1974).

Tetradifon CAS Registry Number: 116-29-0 三氯杀螨砜

CAS Name: 1,2,4-Trichloro-5-[(4-chlorophenyl)sulfonyl]benzene
Additional Names: p-chlorophenyl 2,4,5-trichlorophenyl sulfone; 2,4,5,4'-tetrachlorodiphenyl sulfone; tedion
Trademarks: Tedion-...
Literature References: Prepn: Meltzer, Huisman, US 2812281 (1957 to Phillips); and soly data: Huisman et al., Rec. Trav. Chim. 77, 103 (1958). Toxicity study: Ben-dyke et al., World Rev. Pest Control 9, 119 (1970).

Salicylamide O-Acetic Acid CAS Registry Number: 25395-22-6 (2-氨基甲酰苯氧)乙酸

CAS Name: [2-(Aminocarbonyl)phenoxy]acetic acid
Additional Names: o-(carbamylphenoxy)acetic acid; a-(2-carbamoylphenoxy)acetic acid
Percent Composition: C 55.39%, H 4.65%, N 7.18%, O 32.79%
Literature References: Prepn: Merriman, J. Chem. Soc. 103, 1838 (1913); Tzofin, J. Gen. Chem. USSR 3, 17 (1933); Klosa, Arch. Pharm. 288, 389 (1955); Izumi et al., JP 56 874 (1956 to Yoshitomi). Pharmacokinetics and efficacy: D. Loew et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 30, 509 (1992).

Tetramethyl-p-phenylenediamine CAS Registry Number: 100-22-1 N,N,N',N'-四甲基对苯二胺

CAS Name: N,N,N',N'-Tetramethyl-1,4-benzenediamine
Trademarks: Wurster's reagent; Wurster's blue
Percent Composition: C 73.12%, H 9.82%, N 17.06%
Literature References: Prepn: Meyer, Ber. 36, 2979 (1903); Cox, Smith, J. Org. Chem. 29, 488 (1964).

Phosphorus Triselenide CAS Registry Number: 1314-86-9 四亚磷三硒化物

Additional Names: Tetraphosphorus triselenide
Percent Composition: P 34.34%, Se 65.66%
Literature References: Prepn: Meyer, Z. Anorg. Chem. 30, 258 (1902); 61B, 1807 (1928); Irgolic et al., Inorg. Chem. 4, 1421 (1965).

Nifurtoinol CAS Registry Number: 1088-92-2 硝呋妥因醇

CAS Name: 3-(Hydroxymethyl)-1-[[(5-nitro-2-furanyl)methylene]amino]-2,4-imidazolidinedione
Additional Names: 3-(hydroxymethyl)-1-[(5-nitrofurfurylidene)amino]hydantoin; 1-[(5-nitrofurfurylidene...
Literature References: Prepn: Michels, BE 611941 corresp to US 3446802 (1962, 1969 to Norwich Pharmacal); Spencer, Michels, J. Org. Chem. 29, 3416 (1964).