其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Pipoxolan Hydrochloride CAS Registry Number: 18174-58-8 1,3-二二硫仑-4-1,5,5-二苯基-2-[2-(1-哌啶基)乙基]-,盐酸盐(1:1)

CAS Name: 5,5-Diphenyl-2-[2-(1-piperidinyl)ethyl]-1,3-dioxolan-4-one hydrochloride
Additional Names: 2-(b-N-piperidylethyl)-4,4-diphenyl-1,3-dioxolan-5-one hydrochlorideTrademarks: Rowapraxin (...
Literature References: Prepn: M. Pailer et al., Monatsh. Chem. 99, 891 (1968); GB 1109959 and BE 719230 (1968, 1969 to Rowa-Wagner). Pharmacology and acute toxicity: K. Morsdorf, H. Wengenroth, Pharmacology 3, 193 (1970).

Halopredone Acetate CAS Registry Number: 57781-14-3 醋酸卤泼尼松

CAS Name: (6b,11b)-17,21-Bis(acetyloxy)-2-bromo-6,9-difluoro-11-hydroxypregna-1,4-diene-3,20-dione
Additional Names: 2-bromo-6b,9-difluoro-11b,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-...
Literature References: Prepn: M. Riva, L. Toscano, DE 2508136; M. Riva et al., US 4226862 (1975, 1980 both to Pierrel); L. Toscano et al., J. Med. Chem. 20, 213 (1977). Physico-chemical and analytical studies: eidem, Arzneim.-Forsch. 27, 1636 (1977). Pharmacology: A. Bianchetti et al., ibid. 2096. Clinical study: B. Palmerio, P. Magnani, ibid. 2404. Toxicological study: L. Casilli et al., ibid. 2102.

Trimethylsilyl Triflate CAS Registry Number: 27607-77-8 三氟甲磺酸三甲基硅酯

CAS Name: Trifluoromethanesulfonic acid trimethylsilyl ester
Additional Names: trimethylsilyltrifluoromethane sulfonate
Percent Composition: C 21.62%, H 4.08%, F 25.64%, O 21.60%, S 14.43%, ...
Literature References: Prepn: M. Schmeisser et al., Ber. 103, 868 (1970); H. W. Roesky, H. H. Giere, Z. Naturforsch. 25B, 773 (1970); D. Haebich, F. Effenberger, Synthesis 1978, 755; T. Morita et al., ibid. 1981, 745. As catalytic reagent: H. Vorbrueggen, K. Krolikiewicz, Angew. Chem. Int. Ed. 14, 421 (1975); as silylating agent: G. A. Olah et al., J. Org. Chem. 46, 5212 (1981).

Proflavine CAS Registry Number: 92-62-6 吡啶-3,6-二胺

CAS Name: 3,6-Acridinediamine
Additional Names: 3,6-diaminoacridine; 2,8-diaminoacridine
Percent Composition: C 74.62%, H 5.30%, N 20.08%
Literature References: Prepn: M. Schöpff, Ber. 27, 2320 (1894); DE 230412 (1910 to Cassella), C.A. 5, 2734 (1911); W. P. Thompson, GB 137214 (1919 to Poulenc Frères), C.A. 14, 1445 (1920); A. Albert, J. Chem. Soc. 1941, 121, 484; 1947, 244. Toxicity study: S. D. Rubbo, Br. J. Exp. Pathol. 28, 1 (1947). Review: The Acridines, A. Albert, Ed. (St. Martin's Press, New York, 2nd ed., 1966) pp 300-302; Acridines, R. M. Acheson, Ed. (Interscience, New York, 1956) pp 341-344.

Ranelic Acid CAS Registry Number: 135459-90-4 5-[二(羧甲基)氨基]-2-羧基-4-氰基-3-噻吩乙酸

CAS Name: 5-[Bis(carboxymethyl)amino]-2-carboxy-4-cyano-3-thiopheneacetic acid
Additional Names: 2-[N,N-di(carboxymethyl)amino]-3-cyano-4-carboxymethylthiophene-5-carboxylic acid
Percent Com...
Literature References: Prepn: M. Wierzbicki et al., EP 415850; eidem, US 5128367 (1991, 1992 both to Adir Co.).

Procainamide Hydrochloride CAS Registry Number: 614-39-1 盐酸普鲁卡因胺

CAS Name: 4-Amino-N-[2-(diethylamino)ethyl]benzamide monohydrochloride
Additional Names: procaine amide hydrochloride
Trademarks: Amisalin (Daiichi); Novocamid (Hoechst); Procamide (Sintesa)...
Literature References: Prepn: M. Yamazaki et al., J. Pharm. Soc. Jpn. 73, 294 (1953); Y. Tashika, M. Kuranari, ibid. 1069. Comprehensive description: R. B. Poet, H. Kadin, Anal. Profiles Drug Subs. 4, 333-383 (1975).

p-Dimethylaminobenzalrhodanine CAS Registry Number: 536-17-4 玫瑰红银试剂

CAS Name: 5-[[4-(Dimethylamino)phenyl]methylene]-2-thioxo-4-thiazolidinone
Additional Names: 5-[p-(dimethylamino)benzylidene]rhodanine
Percent Composition: C 54.52%, H 4.58%, N 10.60%, O 6.0...
Literature References: Prepn: Mackie, Misra, J. Chem. Soc. 1954, 3919.

Glybuzole CAS Registry Number: 1492-02-0 格列丁唑

CAS Name: N-[5-(1,1-Dimethylethyl)-1,3,4-thiadiazol-2-yl]benzenesulfonamide
Additional Names: N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide; 2-benzenesulfonamido-5-tert-butyl-1,3,4-t...
Literature References: Prepn: Macrae, Drain, GB 822947 (1959 to Smith Nephew), C.A. 54, 4622h (1960); FR M3389 (1965 to Rhône-Poulenc), C.A. 64, 3553a (1966). Pharmacodynamics: Bargeton et al., Arch. Int. Pharmacodyn. 153, 379 (1965).

Metofenazate CAS Registry Number: 388-51-2 美托奋乃酯

CAS Name: 3,4,5-Trimethoxybenzoic acid 2-[4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl]ethyl ester
Additional Names: 2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]-1-piperazinyl]eth...
Literature References: Prepn: Magy. Kem. Lapja 17, 169 (1962), C.A. 57, 11314d (1962); Toldy et al., Acta Chim. Acad. Sci. Hung. 42, 351 (1964).

Fenadiazole CAS Registry Number: 1008-65-7 2-(1,3,4-噁二唑-2-基)苯酚

CAS Name: 2-(1,3,4-Oxadiazol-2-yl)phenol
Additional Names: 2-(o-hydroxyphenyl)-1,3,4-oxadiazole
Trademarks: Hypnazol (Logeais)
Percent Composition: C 59.26%, H 3.73%, N 17.28%, O 19.73%
Literature References: Prepn: Maillard et al., Bull. Soc. Chim. Fr. 1961, 529; Vincent et al., ibid. 1962, 1580; GB 902388 and Maillard et al., FR M379 C.A. 57, 15251g (1962) (both 1962 to Logeais Labs.).