其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Lamotrigine CAS Registry Number: 84057-84-1 拉莫三嗪

CAS Name: 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine
Additional Names: 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine; LTGTrademarks: Lamictal (GSK)
Percent Composition: C 42.21%, ...
Literature References: Prepn: M. G. Baxter et al., EP 21121 (1981 to Wellcome Foundation); D. A. Sawyer et al., US 4602017 (1986). HPLC determn in plasma: C.-L. Cheng et al., J. Chromatogr. B 817, 199 (2005). Anticonvulsant activity: A. A. Miller et al., Epilepsia 27, 483 (1986). Mechanism of action studies: M. J. Leach et al., ibid. 490; X. Xie, R. M. Hagan, Neuropsychobiology 38, 119 (1998). Series of articles on clinical pharmacology, antiepileptic efficacy and safety: Epilepsia 32, Suppl. 2, S1-S21 (1991). Clinical trial in bipolar depression: J. R. Calabrese et al., J. Clin. Psychiatry 60, 79 (1999). Review of clinical experience in epilepsy: H. Choi, M. J. Morrell, Expert Opin. Pharmacother. 4, 243-251 (2003); in bipolar disorder: Z. Bhagwagar, G. M. Goodwin, Expert Opin. Pharmacother. 6, 1401-1408 (2005).

Bunaftine CAS Registry Number: 32421-46-8 丁萘夫汀

CAS Name: N-Butyl-N-[2-(diethylamino)ethyl]-1-naphthalenecarboxamide
Additional Names: N-butyl-N-[2-(diethylamino)ethyl]-1-naphthamide; bunaphtide; bunaphtine
Percent Composition: C 77.26%, ...
Literature References: Prepn: M. Giannini, DE 2099894 (1971 to Malesci), C.A. 75, 20222a (1971); M. Giannini et al., Farmaco Ed. Sci. 28, 429 (1973). Pharmacology: A. Ferroni, G. Monticelli, Pharmacol. Res. Commun. 5, 151 (1973). Clinical pharmacokinetics: B. Flouvat et al., Therapie 37, 143 (1982).

Carphenazine CAS Registry Number: 2622-30-2 卡奋乃静

CAS Name: 1-[10-[3-[4-(2-Hydroxyethyl)-1-piperazinyl]propyl]-10H-phenothiazin-2-yl]-1-propanone
Additional Names: 10-[3-[4-(2-hydroxyethyl)-1-piperazinyl]propyl]-3-propionylphenothiazine; 2-pro...
Literature References: Prepn: M. H. Sherlock, N. Sperber, US 2985654 (1961 to Schering); R. F. Tislow et al., US 3023146 (1962 to Am. Home Products).

Cyclocumarol CAS Registry Number: 518-20-7 环香豆素

CAS Name: 3,4-Dihydro-2-methoxy-2-methyl-4-phenyl-2H,5H-pyrano[3,2-c][1]benzopyran-5-one
Additional Names: 2-methyl-2-methoxy-4-phenyl-5-oxodihydropyrano[3,2-c][1]benzopyran; 3,4-(2'-methyl-2'-...
Literature References: Prepn: M. Ikawa et al., J. Am. Chem. Soc. 66, 902 (1944); M. A. Stahmann, et al., US 2427579 (1947 to Wisconsin Alumni Res. Found.).

Cyclonium Iodide CAS Registry Number: 6577-41-9 奥沙碘铵

CAS Name: 1-[(2-Cyclohexyl-2-phenyl-1,3-dioxolan-4-yl)methyl]-1-methylpiperidinium iodide
Additional Names: N-methyl-N-[(2-cyclohexyl-2-phenyl-1,3-dioxolan-4-yl)-methyl]piperidinium iodide; 1-(...
Literature References: Prepn: M. Kimura et al., JP 66 6585 (1966 to Toyama), C.A. 65, 7191 (1966); and separation of isomers: I. Saikawa, JP 70 16475 (1970 to Toyama), C.A. 73, 45355t. Stability studies: Shiuchi, Miyazaki, Bunseki Kagaku 18, 455 (1969), C.A. 71, 74097z (1969). Incompatibility studies: Kunita et al., Yakuzaigaku 28, 84 (1968), C.A. 69, 99335x (1968). Anticholinergic activity and acute toxicity: J. Faff et al., Pol. J. Pharmacol. Pharm. 30, 493 (1978). Review: Jpn. Med. Gaz. 8(9), 11 (1971).

Metoserpate CAS Registry Number: 1178-28-5 美托舍酯

CAS Name: (3b,16b,17a,18a,20a)-11,17,18-Trimethoxyyohimban-16-carboxylic acid methyl ester
Additional Names: O-methyl-18-epireserpic acid methyl ester; 18-epi-O-methylreserpic acid methyl ester...
Literature References: Prepn: M. M. Robison et al., Experientia 17, 14 (1961); eidem, J. Am. Chem. Soc. 83, 2694 (1961); R. A. Lucas et al., US 3120532; US 3126390; M. M. Robison, R. A. Lucas, US 3151117 (all 1964 to Ciba); Ziegler, US 3264303 (1966 to Ciba).

Tinoridine CAS Registry Number: 24237-54-5 2-氨基-6-苄基-4,5,6,7-四氢噻吩并[2,3-c]吡啶-3-甲酸乙酯

CAS Name: 2-Amino-4,5,6,7-tetrahydro-6-(phenylmethyl)thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester
Additional Names: 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic ...
Literature References: Prepn: M. Nakanishi et al., DE 1812404; eidem, US 3563997 (1969, 1971 both to Yoshitomi). Pharmacological studies: M. Nakanishi et al., J. Pharm. Soc. Jpn. 90, 272-334 (1970), C.A. 73, 54504t-54510s (1970); eidem, Arzneim.-Forsch. 20, 998, 1004 (1970); Yakuri to Chiryo 2, 1028 (1974). Protective effect vs carbon tetrachloride hepatotoxicity: H. Yasuda et al., Toxicol. Appl. Pharmacol. 52, 407 (1980).

Pranoprofen CAS Registry Number: 52549-17-4 普拉洛芬

CAS Name: a-Methyl-5H-[1]benzopyrano[2,3-b]pyridine-7-acetic acid
Additional Names: 2-(5H-[1]benzopyrano[2,3-b]pyridin-7-yl)propionic acidTrademarks: Niflan (Yoshitomi)
Percent Composition: ...
Literature References: Prepn: M. Nakanishi et al., DE 2337052; eidem, US 3931205 (1974, 1976 both to Yoshitomi); eidem, Yakugaku Zasshi 96, 99 (1976), C.A. 84, 135515b (1976). Physicochemical properties: M. Nobutoki, Y. Ota, Iyakuhin Kenkyu 7, 200 (1976), C.A. 88, 110468h (1978). Absorption, metabolism, distribution, excretion: Y. Kato et al., Yakuri to Chiryo 4, 1473 (1976), C.A. 88, 130710j (1978). Pharmacological study: Y. Maruyama et al., Nippon Yakurigaku Zasshi 73, 113 (1977), C.A. 88, 276m (1978). Toxicity study: M. Edanaga et al., Iyakuhin Kenkyu 7, 211 (1976), C.A. 88, 131015y (1978).

Clocapramine CAS Registry Number: 47739-98-0 氯卡比咪嗪

CAS Name: 1'-[3-(3-Chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl][1,4'-bipiperidine]-4'-carboxamide
Additional Names: 3-chloro-5-[3-(4-piperidino-4-carbamoylpiperidino)propyl]-10,11-dih...
Literature References: Prepn: M. Nakanishi, C. Tashiro, DE 1905765; eidem, US 3668210 (1969, 1972, both to Yoshitomi); M. Nakanishi et al., J. Med. Chem. 13, 644 (1970). Pharmacology and toxicity: M. Nakanishi et al., Arzneim.-Forsch. 21, 391 (1971). Effect on metabolism of serotonin and catecholamines: M. Nakanishi, M. Setoguchi, ibid. 23, 806 (1973). Metabolism: M. Nakanishi et al., J. Pharm. Soc. Jpn. 91, 1042 (1971). HPLC determn in plasma: K. Hikida et al., Anal. Sci. 6, 367 (1990). Review: Jpn. Med. Gaz. 10(7), 5 (1973).

Carpipramine CAS Registry Number: 5942-95-0 卡匹帕明

CAS Name: 1'-[3-(10,11-Dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]-[1,4'-bipiperidine]-4'-carboxamide
Additional Names: 5-[3-(4-piperidino-4-carbamoylpiperidino)propyl]-10,11-dihydro-5H-dibenz[b,...
Literature References: Prepn: M. Nakanishi, T. Munakata, JP 66 6752; GB 1017986; Nakanishi et al., US 3329683 (1966, 1966, 1967 all to Yoshitomi); Nakanishi et al., J. Med. Chem. 13, 644 (1970). Pharmacology: Nakanishi et al., Arzneim.-Forsch. 18, 1435 (1968). Metabolism: Nakanishi et al., J. Pharm. Soc. Jpn. 90, 204 (1970).