其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Phenocoll CAS Registry Number: 103-97-9 2-氨基-N-(4-乙氧基苯基)乙酰胺

CAS Name: 2-Amino-N-(4-ethoxyphenyl)acetamide
Additional Names: 2-amino-p-acetophenetidide; a-amino-p-acetophenetide; aminoacetophenetidine; 4-glycylaminophenol ethyl ether; glycine p-phenetidi...
Literature References: Prepn: Majert, DE 59121; DE 59874 (1891 to Schering), Frdl. 3, 915, 918; DE 346809 (1921 to Schering), Frdl. 13, 1066; Karrer, Haebler, Helv. Chim. Acta 7, 534 (1924).

Prednylidene CAS Registry Number: 599-33-7 泼尼立定

CAS Name: (11b)-11,17,21-Trihydroxy-16-methylenepregna-1,4-diene-3,20-dione
Additional Names: D1,4-pregnadiene-16-methylene-11b,17a,21-triol-3,20-dione; 16-methylene-11b,17a,21-trihydroxypregna...
Literature References: Prepn: Mannhardt et al., Tetrahedron Lett. no. 16, 21 (1960). Prepn of the 21-diethylaminoacetate: idem et al., DE 1134074 (1962 to E. Merck), C.A. 58, 568a (1963).

Pimeclone CAS Registry Number: 534-84-9 哌美克隆

CAS Name: 2-(1-Piperidinylmethyl)cyclohexanone
Additional Names: 2-(piperidinomethyl)cyclohexanonePercent Composition: C 73.80%, H 10.84%, N 7.17%, O 8.19%
Literature References: Prepn: Mannich, Honig, Arch. Pharm. 265, 598 (1927); Dimroth et al., Ber. 73, 1399 (1940).

Dimethocaine CAS Registry Number: 94-15-5 二甲卡因

CAS Name: 3-(Diethylamino)-2,2-dimethyl-1-propanol p-aminobenzoate
Additional Names: 3-diethylamino-2,2-dimethylpropyl p-aminobenzoate; 1-aminobenzoyl-2,2-dimethyl-3-diethylaminopropanol; p-ami...
Literature References: Prepn: Mannich, Wilder, Ber. 65, 378 (1932); C. Mannich, US 1889678 (1932). Pharmacology: O. Gebner et al., Arch. Exp. Pathol. Pharmakol. 168, 447 (1932); and toxicology review: A. D. Hirschfelder, R. N. Bieter, Physiol. Rev. 12, 190-282 (1932).

Chlorpropamide CAS Registry Number: 94-20-2 氯磺丙脲

CAS Name: 4-Chloro-N-[(propylamino)carbonyl]benzenesulfonamide
Additional Names: 1-(p-chlorophenylsulfonyl)-3-propylurea; 1-(p-chlorobenzenesulfonyl)-3-propylurea; N-propyl-N'-(p-chlorobenzenes...
Literature References: Prepn: Marshall, Sigal, J. Org. Chem. 23, 927 (1958); GB 853555; W. M. McLamore, US 3349124 (1960, 1967 both to Pfizer); Bauer et al., J. Org. Chem. 31, 3440 (1960). Pharmacology and metabolism: Khurana et al., Indian J. Med. Res. 55, 1084 (1967); Brotherton et al., Clin. Pharmacol. Ther. 10, 505 (1969); Madsen et al., Eur. J. Pharmacol. 13, 374 (1971). Toxicity study: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).

Crotethamide CAS Registry Number: 6168-76-9 克罗乙胺

CAS Name: N-[1-[(Dimethylamino)carbonyl]propyl]-N-ethyl-2-butenamide
Additional Names: N-(1-dimethylcarbamoylpropyl)-N-ethylcrotonamide; a-(N'-crotonyl-N'-ethyl)amino-N,N-dimethylbutyramide
...
Literature References: Prepn: Martin, Gysin, US 2447587 (1948 to Geigy).

Cropropamide CAS Registry Number: 633-47-6 克罗丙胺

CAS Name: N-[1-[(Dimethylamino)carbonyl]propyl]-N-propyl-2-butenamide
Additional Names: N-(1-dimethylcarbamoylpropyl)-N-propylcrotonamide; a-(N'-crotonyl-N'-propyl)amino-N,N-dimethylbutyramide<...
Literature References: Prepn: Martin, Gysin, US 2447587 (1948 to Geigy).

Benzonatate CAS Registry Number: 104-31-4 苯佐那酯

CAS Name: 4-(Butylamino)benzoic acid 3,6,9,12,15,18,21,24,27-nonaoxaoctacos-1-yl ester
Additional Names: nonaethyleneglycol monomethyl ether p-n-butylaminobenzoate; p-butylaminobenzoic acid w-O...
Literature References: Prepn: Matter, US 2714608 (1955 to Ciba).

Amoproxan CAS Registry Number: 22661-76-3 克冠吗啉

CAS Name: 3,4,5-Trimethoxybenzoic acid 1-[(3-methylbutoxy)methyl]-2-(4-morpholinyl)ethyl ester
Additional Names: 3,4,5-trimethoxybenzoic acid 1-[(isopentyloxy)methyl]-2-morpholinoethyl ester; a...
Literature References: Prepn: Mauvernay et al., GB 1211307 corresp to US 3781432 (1970, 1973 to C.E.R.M.) and US 3790569 (1974). Pharmacology: Duchene-Marullaz et al., Therapie 24, 665 (1969); Pernod et al., ibid. 675; Roulet et al., ibid. 27, 93 (1972).

Alloclamide CAS Registry Number: 5486-77-1 阿洛拉胺

CAS Name: 4-Chloro-N-[2-(diethylamino)ethyl]-2-(2-propenyloxy)benzamide
Additional Names: 2-(allyloxy)-4-chloro-N-[2-(diethylamino)ethyl]benzamide
Percent Composition: C 61.83%, H 7.46%, Cl ...
Literature References: Prepn: Mauvernay, US 3160557 (1964 to C.E.R.M.).