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Proflavine CAS Registry Number: 92-62-6 吡啶-3,6-二胺


CAS Name: 3,6-Acridinediamine
Additional Names: 3,6-diaminoacridine; 2,8-diaminoacridine
Percent Composition: C 74.62%, H 5.30%, N 20.08%
📌 参考资料/链接:
Literature References: Prepn: M. Schöpff, Ber. 27, 2320 (1894); DE 230412 (1910 to Cassella), C.A. 5, 2734 (1911); W. P. Thompson, GB 137214 (1919 to Poulenc Frères), C.A. 14, 1445 (1920); A. Albert, J. Chem. Soc. 1941, 121, 484; 1947, 244. Toxicity study: S. D. Rubbo, Br. J. Exp. Pathol. 28, 1 (1947). Review: The Acridines, A. Albert, Ed. (St. Martin's Press, New York, 2nd ed., 1966) pp 300-302; Acridines, R. M. Acheson, Ed. (Interscience, New York, 1956) pp 341-344.

📄 详细内容


Properties: Yellow needles from alc, mp 281° (Schöpff), mp 288° (Albert). Sol in water, ethanol. Practically insol in benzene, ether. pKa 9.7. Solns are brownish and when diluted are fluorescent. Solns should be discarded when they become turbid. LD50 s.c. in mice: 0.14 g/kg (Rubbo).
Melting point: mp 281° (Schöpff); mp 288° (Albert)
pKa: pKa 9.7
Toxicity data: LD50 s.c. in mice: 0.14 g/kg (Rubbo)
Derivative Type: Dihydrochloride
CAS Registry Number: 531-73-7
Percent Composition: C 55.34%, H 4.64%, N 14.89%, Cl 25.13%
Properties: Orange-yellow needles. pH of 0.1% soln 2.5-3.0.
Derivative Type: Sulfate
CAS Registry Number: 553-30-0
Additional Names: Proflavine hemisulfate; neutral proflavine sulfate
Percent Composition: C 50.81%, H 4.26%, N 13.67%, S 10.43%, O 20.82%
Properties: Occurs as the hydrate. Red needles, hygroscopic. Sol in 300 parts cold water, in 1 part boiling water; slightly sol in alc. Practically insol in ether, CHCl3. pH of satd soln is 6-8. pH of 0.1% soln is 2.5.
Derivative Type: Mixture with 3,6-diamino-10-methylacridinium chloride see Acriflavine
Therap-Cat: Topical antiseptic.
Therap-Cat-Vet: Topical antiseptic.
产品链接: 92-62-6››