CAS: 92-62-6; Acridine-3,6-Diamine

相似化合物

952-23-8 90-45-9 553-30-0

上下游产品

3,6-二氨基-9-吖啶酮 3,6-Diaminoacridone 42832-87-1

📜间苯二胺置于氨,草酸,Zinc(II) Chloride体系中,化学反应 0.75H,反应生成 原黄素
参考文献:基于 Atrp 的 Ph 敏感两亲嵌段聚合物及其自组装胶束的合成与空心介孔二氧化硅作为 Dox 载体用于控制药物释放
标题:基于 Atrp 的 Ph 敏感两亲嵌段聚合物及其自组装胶束的合成与空心介孔二氧化硅作为 Dox 载体用于控制药物释放
摘要:使用具有荧光发色团的引发剂 3,6-二溴-异丁酰胺吖啶 (Dia) 成功制备了基于原子转移自由基聚合 (Atrp) 的 Ph 敏感荧光聚合物 (Psdma-B-Poegma) 的合成,以引发亲油性单体 2-Styryl-1,3-Dioxan-5-Yl Methacrylate (Sdma) 和亲水性单体低聚(乙二醇)甲基醚 (Oegma),其包含肉桂醛缩醛结构.通过添加中空介孔硅(Hms@c18),通过一种自组装过程,作为抗癌药物阿霉素(dox)的载体,用于载药和控释.纳米复合材料显示出更高的载药能力,远高于使用普通胶束观测到的载药能力.同时,包覆在纳米粒子表面的聚合物含有引发剂的荧光片段,可用于细胞的荧光对比.相对于人正常成纤维细胞gm,纳米复合载体选择性地抑制人黑色素瘤细胞a375.体外结果表明,成功制备了一种智能 Ph 敏感纳米颗粒药物递送系统,可用于癌症诊断和治疗.
DOI:10.1039/d1Ra03899K

专利信息

专利号:US-5139940-A
优先权日:1989-10-26
标题 :Activation compounds and methods of synthesis of activation compounds
发明人：ISAACS STEPHEN T; CIMINO GEORGE D; METCHETTE KENNETH C; TESSMAN JOHN W
权利人:ISAACS STEPHEN T; CIMINO GOERGE D; METCHETTE KENNETH C; TESSMAN JOHN W
摘要:The invention is directed to isopsoralen compound compositions that contain a variety of substitutions which yet permit their binding to nucleic acid polymers. Reaction conditions that activate these bound isopsoralens results in covalent crosslinking to the nucleic acid polymers. The resultant complex is inhibited from being a template for the template-directed enzymatic synthesis of a complementary nucleic acid polymer. Beside the isopsoralens compositions, the invention includes their synthesis, the nucleic acid complex production and detection, and the above inhibitory method of use of the isopsoralens.

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-8735586-B2
优先权日:2007-06-26
标 题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR; SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:EP-2173747-B1
优先权日:2007-06-26
标 题:A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; R KYEN OMAR; URMANN MATHIAS; HALLAND NIS
权利人:SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R1; R2; R3; R4; J1; J2; J3; J4 and G have the meanings indicated in the claims. The present invention provides a direct metal, e.g. palladium or copper, catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:US-9625466-B2
优先权日:2011-04-06
标题 :Signal amplification methods for the imaging of protein synthesis and neurotransmitter transport
发明人：BLANCHARD SCOTT C; ALTMAN ROGER B
权利人:BLANCHARD SCOTT C; ALTMAN ROGER B; UNIV CORNELL
摘要:The present invention describes the synthesis of biological samples that can be used for the purpose of enhancing the signal-to-noise ratios achievable during the imaging of protein synthesis, amino acid transport and neurotransmitter transport, particularly in applications where single-molecule resolution is demanded. The present invention provides quencher-labeled elongation factor (EF-Tu) and fluorophore-labeled tRNA. When these molecules are present in a ternary complex with GTP, the fluorescently-labeled tRNA is quantitatively quenched. Once the tRNA is incorporated into an actively translating ribosome, however, a burst of fluorescence is released and can be detected by a variety of techniques, including smFRET imaging. The invention further provides novel EF-Tu constructs for achieving quencher labeling at high levels while retaining native or near native activity in the translation reactions, as well as methods for preparing stable ternary complexes, methods of protein sequencing, methods of detecting amino acid transport using a proteoliposome assay system and the proteoliposomes systems and methods of imaging translation events in single living cells. The present invention should have an immediate impact on next-generation sequencing technologies and the detection of neurotransmitter transporter activities in both in vitro and in vivo settings, a critical component of drug activity/screening assays targeting this important class of molecules.

专利号:US-9034576-B2
优先权日:2009-09-24
标题 :Systems and methods for measuring translation of target proteins in cells
发明人：SMILANSKY ZEEV; COOPERMAN BARRY S; GOODMAN YALE E
权利人:SMILANSKY ZEEV; COOPERMAN BARRY S; GOODMAN YALE E; ANIMA CELL METROLOGY INC
摘要:The present invention relates to systems and methods for measuring the rate of translation of a target protein in cells, which are based on the detection of translation of one or more predetermined codon pairs during synthesis of the target protein. The detection is provided by a FRET signal emitted from labeled tRNA molecules which are juxtaposed during synthesis of the protein.