其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

DFDD CAS Registry Number: 603-55-4 1,1'-(2,2-二氯乙亚基)二[4-氟苯]

CAS Name: 1,1'-(2,2-Dichloroethylidene)bis[4-fluorobenzene]
Additional Names: 1,1-dichloro-2,2-bis(p-fluorophenyl)ethane; difluorodiphenyldichloroethane
Percent Composition: C 58.56%, H 3.51...
Literature References: Prepn: Müller, Helv. Chim. Acta 9, 1560 (1946).

Dimemorfan CAS Registry Number: 36309-01-0 二甲啡烷

CAS Name: (9a,13a,14a)-3,17-Dimethylmorphinan
Additional Names: d-3-methyl-N-methylmorphinanPercent Composition: C 84.65%, H 9.87%, N 5.48%
Literature References: Prepn: Murakami et al., DE 2128607; eidem, US 3786054 (1971, 1974 both to Yamanouchi); eidem, Chem. Pharm. Bull. 20, 1706 (1972). Pharmacology: Ida, Fujii, Oyo Yakuri 6, 1207 (1972); Y. Kasé et al., Arzneim.-Forsch. 26, 353 (1976).

Cyclandelate CAS Registry Number: 456-59-7 扁桃酸3,3,5-三甲基环己基酯

CAS Name: a-Hydroxybenzeneacetic acid 3,3,5-trimethylcyclohexyl ester
Additional Names: mandelic acid 3,3,5-trimethylcyclohexyl ester; 3,3,5-trimethylcyclohexyl mandelate; 3,5,5-trimethylcycloh...
Literature References: Prepn: N. Brock et al., Arzneim.-Forsch. 2, 165 (1952); A. B. H. Funcke et al., ibid. 3, 503 (1953); van Sluis, Chem. Prod. 17, 375 (1954); GB 707227; W. T. Nauta, US 2707193 (1954, 1955 both to Brocades-Stheeman). Purification: D. Flitter, US 3663597 (1972 to Am. Home Prods.). Pharmacokinetics: A. Orr, J. R. Whittier, Int. J. Nucl. Med. Biol. 1, 205 (1974). GLC determn in human plasma: G. Andermann, M. Dietz, J. Chromatogr. 223, 365 (1981). Clinical trial in chronic cerebrovascular disease: S. Bassi et al., Br. J. Clin. Pract. 38, 344 (1984). Review of efficacy as cerebral and peripheral vasodilator: C. B. Blakemore, ibid. 34, Suppl., 3-9 (1984). Symposium on calcium modulation and clinical effects: Drugs 33, Suppl. 2, 1-141 (1987). Comprehensive description: C. M. Shearer, Anal. Profiles Drug Subs. Excip. 21, 149-168 (1992).

Prilocaine CAS Registry Number: 721-50-6 丙胺卡因

CAS Name: N-(2-Methylphenyl)-2-(propylamino)propanamide
Additional Names: 2-(propylamino)-o-propionotoluidide; N-(a-propylaminopropionyl)-o-toluidine; a-propylamino-2-methylpropionanilide; prop...
Literature References: Prepn: N. Löfgren, C. Tegner, Acta Chem. Scand. 14, 486 (1960); GB 839943; N. Löfgren, C. Tegner, US 3160662 (1960, 1964 both to Astra).

Alclofenac CAS Registry Number: 22131-79-9 烯氯苯乙酸

CAS Name: 3-Chloro-4-(2-propenyloxy)benzeneacetic acid
Additional Names: [4-(allyloxy)-3-chlorophenyl]acetic acidTrademarks: Allopydin (Chugai); Epinal (Kyorin); Mervan (Continental Pharma); Re...
Literature References: Prepn: N. P. Buu-Hoi et al., BE 704368 (1968 to Madan). Pharmacology: eidem, Naturwissenschaften 56, 330 (1969). Series of articles on pharmacology, toxicology and metabolism: Arzneim.-Forsch. 20, 610-636 (1970). Toxicity data: G. Lambelin et al., ibid. 618. Clinical studies: F. Lambotte, ibid. 569; Van Hoek, Curr. Ther. Res. 12, 551 (1970).

Allyl acetate CAS Registry Number: 591-87-7 乙酸烯丙酯

CAS Name: Acetic acid 2-propenyl ester
Additional Names: 3-acetoxy-1-propene
Percent Composition: C 59.98%, H 8.05%, O 31.96%
Literature References: Prepn: N. Zinin, Ann. 1855, 361; K. N. Gurudutt et al., Tetrahedron 38, 1843 (1982); and physical properties: G. H. Jeffery, A. I. Vogel, J. Chem. Soc. 1948, 658. Vibrational spectra and thermodynamic functions: B. Singh et al., Proc. Indian Acad. Sci. 89, 201 (1980). Acute toxicity: H. F. Smyth, Jr. et al., J. Ind. Hyg. Toxicol. 31, 60 (1949); P. M. Jenner et al., Food Cosmet. Toxicol. 2, 327 (1964). Effect on respiratory function in mice: G. D. Nielsen et al., Acta Pharmacol. Toxicol. 54, 292 (1984).

Alfaxalone CAS Registry Number: 23930-19-0 阿法沙龙

CAS Name: (3a,5a)-3-Hydroxypregnane-11,20-dione
Additional Names: alphaxalonePercent Composition: C 75.86%, H 9.70%, O 14.44%
Literature References: Prepn: Nagata et al., Helv. Chim. Acta 42, 1399 (1959); Browne, Kirk, J. Chem. Soc. C 1969, 1653; Davis et al., DE 2030402; ZA 7003861 (both 1971 to Glaxo), C.A. 75, 20793n, 64114w (1971). Mass spectral data: Ende, Spiteller, Monatsh. Chem. 102, 929 (1971). Review of pharmacology and clinical efficacy of mixture with alfadolone acetate, q.v.: Postgrad. Med. J. 48, Suppl. 2, 1-139 (1972). See also Child et al.; Campbell et al.; Br. J. Anaesth. 43, 2-24 (1971); Lancet 1, 888 (1972). Pharmacology and toxicity data: M. I. Al-Khawashki et al., J. Egypt. Med. Assoc. 62, 191 (1979).

Fenozolone CAS Registry Number: 15302-16-6 非诺唑酮

CAS Name: 2-(Ethylamino)-5-phenyl-4(5H)-oxazolone
Additional Names: 2-ethylamino-4-oxo-5-phenyl-D2-oxazoline; 5-phenyl-2-(ethylimino)-4-oxazolidone; 5-phenyl-2-ethylamino-4-oxazolinoneTrademark...
Literature References: Prepn: Najer, Giudicelli, Bull. Soc. Chim. Fr. 1961, 1231; BE 613985 and DE 1297108 (1962, 1969 both to Dausse), C.A. 57, 13761a (1962); 71, 70586k (1969). Exists predominantly in the tautomeric ethylaminooxazolinone form: Najer et al., Compt. Rend. 254, 2173 (1962). Activity studies: Giudicelli et al., ibid. 2862.

Clospirazine CAS Registry Number: 24527-27-3 螺氯马嗪

CAS Name: 8-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-thia-4,8-diazaspiro[4.5]decan-3-one
Additional Names: 8-[3-(2-chloro-10-phenothiazinyl)propyl]-3-oxo-1-thia-4,8-diazaspiro[4.5]decane; ...
Literature References: Prepn: Nakanishi et al., JP 69 23091; US 3574204 (1969, 1971 both to Yoshitomi). Pharmacological and metabolic studies: Nakanishi et al., J. Pharm. Soc. Jpn. 90, 800, 808 (1970); Imamura et al., ibid. 813. Review: Jpn. Med. Gaz. 8(11), 10 (1971).

Vanadium Carbonyl CAS Registry Number: 20644-87-5

Additional Names: Vanadium hexacarbonyl
Percent Composition: C 32.91%, O 43.83%, V 23.26%
Literature References: Prepn: Natta et al., C.A. 54, 16252 (1960); Ercoli et al., J. Am. Chem. Soc. 82, 2966 (1960); Hileman in Prep. Inorg. React. 1, 107 (1964).