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Clospirazine CAS Registry Number: 24527-27-3 螺氯马嗪

CAS Name: 8-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-thia-4,8-diazaspiro[4.5]decan-3-one
Additional Names: 8-[3-(2-chloro-10-phenothiazinyl)propyl]-3-oxo-1-thia-4,8-diazaspiro[4.5]decane; spiclomazine
Percent Composition: C 59.24%, H 5.42%, Cl 7.95%, N 9.42%, O 3.59%, S 14.38%

📌 参考资料/链接：
Literature References: Prepn: Nakanishi et al., JP 69 23091; US 3574204 (1969, 1971 both to Yoshitomi). Pharmacological and metabolic studies: Nakanishi et al., J. Pharm. Soc. Jpn. 90, 800, 808 (1970); Imamura et al., ibid. 813. Review: Jpn. Med. Gaz. 8(11), 10 (1971).

📄 详细内容

Properties: mp 154-156° (acetone).
Melting point: mp 154-156° (acetone)
Derivative Type: Hydrochloride
CAS Registry Number: 27007-85-8Trademarks: Diceplon (Yoshitomi); Disepron (Yoshitomi)
Properties: White to brownish, tasteless, odorless crystals or powder, mp 262-264° (dec). Sparingly sol in methanol; slightly sol in chloroform; very slightly sol in water. Decomposes slowly when exposed to light. LD50 in mice, rats (mg/kg): 3400, 2950 i.p.; 5490, 5490 s.c.; 3800, 4000 orally (Nakanishi, 1970).
Melting point: mp 262-264° (dec)
Toxicity data: LD50 in mice, rats (mg/kg): 3400, 2950 i.p.; 5490, 5490 s.c.; 3800, 4000 orally (Nakanishi, 1970)
Therap-Cat: Antipsychotic.
Keywords: Antipsychotic; Phenothiazines.
产品链接: 24527-27-3››

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