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Alfaxalone CAS Registry Number: 23930-19-0 阿法沙龙

CAS Name: (3a,5a)-3-Hydroxypregnane-11,20-dione
Additional Names: alphaxalonePercent Composition: C 75.86%, H 9.70%, O 14.44%

📌 参考资料/链接：
Literature References: Prepn: Nagata et al., Helv. Chim. Acta 42, 1399 (1959); Browne, Kirk, J. Chem. Soc. C 1969, 1653; Davis et al., DE 2030402; ZA 7003861 (both 1971 to Glaxo), C.A. 75, 20793n, 64114w (1971). Mass spectral data: Ende, Spiteller, Monatsh. Chem. 102, 929 (1971). Review of pharmacology and clinical efficacy of mixture with alfadolone acetate, q.v.: Postgrad. Med. J. 48, Suppl. 2, 1-139 (1972). See also Child et al.; Campbell et al.; Br. J. Anaesth. 43, 2-24 (1971); Lancet 1, 888 (1972). Pharmacology and toxicity data: M. I. Al-Khawashki et al., J. Egypt. Med. Assoc. 62, 191 (1979).

📄 详细内容

Properties: Colorless prisms from ether, mp 172-174°. [a]D26 +113.4° (c = 1.2 in chloroform). LD50 i.v. in mice: 43 mg/kg (Al-Khawashki).
Melting point: mp 172-174°
Optical Rotation: [a]D26 +113.4° (c = 1.2 in chloroform).
Toxicity data: LD50 i.v. in mice: 43 mg/kg (Al-Khawashki)
Derivative Type: Mixture with alfadolone acetate
CAS Registry Number: 8067-82-1
Additional Names: Alphadione; alfadioneTrademarks: Alfatésin (Glaxo); Althesin (Glaxo); Saffan (Mallinckrodt)
Properties: LD50 in mice (mg/kg): 140 i.p., 47 i.v. (Al-Khawashki).
Toxicity data: LD50 in mice (mg/kg): 140 i.p., 47 i.v. (Al-Khawashki)
Therap-Cat: Combination with alfadolone acetate as anesthetic (intravenous).
Therap-Cat-Vet: Combination with alfadolone acetate as anesthetic (intravenous).
Keywords: Anesthetic (Intravenous).
产品链接: 23930-19-0››

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