CAS: 23930-19-0; (3R,5S,8S,9S,10S,13S,14S,17S)-17-Acetyl-3-Hydroxy-10,13-Dimethyl-1,2,3,4,5,6,7,8,9,12,14,15,16,17-Tetradecahydrocyclopenta[a]Phenanthren-11-One

上下游产品

5α-pregnane-3,11,20-trione 3β-acetoxy-5α,9β-pregnane-11,20-dione 3β-acetoxy-5α-pregnane-11,20-dione 5α-pregnane-3,11,20-trione (3β,5α)-3,17-dihydroxypregnane-11,20-dione 3β-(toluene-4-sulfonyloxy)-5α-pregnane-11,20-dione (3β,5α)-21-(acetyloxy)-3-{[(4-methylphenyl)sulfonyl]oxy}pregnane-11,20-dione

📜3β-Acetoxy-5α-Pregnane-11,20-Dione置于氢氧化钾,N,N-二甲基甲酰胺体系中,化学反应生成阿法沙龙
参考文献:3α,21-二乙酰氧基-17-羟基-5α-孕烯二酮-(11,20)的合成.肾上腺皮质成分和相关物质,第99部分†
标题:3α,21-二乙酰氧基-17-羟基-5α-孕烯二酮-(11,20)的合成.肾上腺皮质成分和相关物质,第99部分†
摘要:从3β-羟基5α-开始,合成3α,21-二乙酰氧基-17α-羟基-5α-孕烯二酮-(ii,20)(xvii,«subst.11-Dehydro-C»的二-O-乙酰基衍生物) Pregnandione-(11,20)在gallagher等人的帮助下.描述了15)和kritchevsky&gallacher 21)开发的方法.
Doi:10.1002/hlca.19590420504

专利信息

专利号:US-2023301584-A1
优先权日:2022-01-26
标 题 :Nanosensor for real-time monitoring of wound healing, manufacturing method thereof, and real-time monitoring system for wound healing using same
发明人：JANG WOO YOUNG; HWANG JANGSUN; XU CHENJIE
权利人:UNIV KOREA RES & BUS FOUND; UNIV CITY HONG KONG
摘要:The present disclosure relates to a nanosensor for real-time monitoring of wound healing, a manufacturing method thereof, and a real-time monitoring system for wound healing using the same. A nanosensor according to example embodiments includes a biomarker for detecting mRNA and a reference gene on gold nanoparticles, thereby providing an objective indicator through monitoring of wound healing, enabling monitoring of wound healing through direct monitoring using real-time fluorescence by including a fluorescent marker in a nanoflare, and enabling evaluation of a whole wound healing process in normal and patient groups (diabetes) through real-time monitoring. In addition, the nanosensor according to the example embodiments has advantages of shortening synthesis time and improving efficiency by 30% through integration of a novel synthesis method (freezing method) rather than an existing synthesis method (salt aging).

专利号:US-6333317-B1
优先权日:1997-03-28
标 题:Regulation of amyloid precursor protein (APP) expression by administration of an estrogenic compound
发明人：LEE ROBERT K K; WURTMAN RICHARD J
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:It has been discovered that lipophilic hormones that interact with cytosolic or nuclear receptors regulate APP expression and synthesis, through modification of APP mRNA stability and/or regulation of APP gene transcription and translation activities. These studies demonstrate that the treatment of brain cells with estrone or 17β-estradiol results in a reduction in the level of APP holoprotein expression, without a concomitant change in the total level of cell protein. The reduction in the level of APP holoprotein caused by estrone or 17β-estradiol is also expected to reduce the production of neurotoxic APP fragments. In as much as estrogen deficiency in postmenopausal women is associated with a higher incidence of Alzheimer's disease, this discovery opens the possibility that estrogen therapy may prevent some of the neurodegenerative and cognitive changes associated with Alzheimer's disease, aging and other disease conditions associated with such neurodegenerative and cognitive decline.

专利号:WO-2025090435-A1
优先权日:2023-10-26
标题 :Alfaxalone synthesis
发明人：LIN ANDREW JENG SHYAN; SCOTT CAMPBELL F; RANASHINGHE RANE; MCLAREN LOUISE SALLY; WEBBER JESSIE LAUREN
权利人:ZOETIS SERVICES LLC
摘要:A process for preparing and purifying alfaxalone (3α-hydroxy-5α-pregnane) from a crude mixture of 3α- and 3β-hydroxy-5α-pregnane; and subsequent purification of the 17α- and 17β-enantiomers to obtain the 17β- enantiomer (alfaxalone).

专利号:MX-2009002267-A
优先权日:2006-08-28
标题:PROCEDURE AND INTERMEDIARIES FOR THE SYNTHESIS OF DERIVATIVES AND INTERMEDIARIES OF (3-ALQUIL-5-PIPERIDIN-1-IL-3,3A-DIHIDRO-PIRAZOLO [1,5-A] PIRIMIDIN-7-IL) -AMINO.

专利号:CN-119192270-A
优先权日:2024-09-20
标题:Synthesis method of alfasin intermediate and synthesis method of alfasin

专利号:US-2006052356-A1
优先权日:2004-09-03
标 题:Pharmacological methods to modulate oxygen consumption
发明人：WARD KEVIN R; BARBEE R W; REYNOLDS PENNY; DIEGLEMANN ROBERT; KUKREJA RAKESH; SPIESS BRUCE; EVANS MELISSA; EDWARDS ERIC
权利人:WARD KEVIN R; BARBEE R W; REYNOLDS PENNY; DIEGLEMANN ROBERT; KUKREJA RAKESH; SPIESS BRUCE; EVANS MELISSA; EDWARDS ERIC
摘要:Methods of modulating oxygen consumption in tissues are provided. In particular, the methods involve the administration of agents that transiently inhibit protein synthesis. The methods are used to treat ischemia and reperfusion-related injuries by temporarily decreasing oxygen consumption needs, and/or by inhibiting inflammation that results from reperfusion.