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Diphenidol CAS Registry Number: 972-02-1 地芬尼多

CAS Name: a,a-Diphenyl-1-piperidinebutanol
Additional Names: 1,1-diphenyl-4-piperidino-1-butanol; diphenyl-[3-(1-piperidyl)propyl]carbinol; defenidolPercent Composition: C 81.51%, H 8.79%, N 4.53%, O 5.17%

📌 参考资料/链接：
Literature References: Prepn: Miescher, Marxer, US 2411664 (1946 to Ciba); Barrett, Wilkinson, GB 683950 (1952 to Wellcome Foundation), C.A. 48, 2112e (1954). Structure-activity studies: Gautier et al., Med. Pharmacol. Exp. 13, 325 (1965). Clinical studies: Cutt et al., Aerosp. Med. 39, 682 (1968); Benson, ibid. 40, 589 (1969). Acute toxicity: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).

📄 详细内容

Properties: Needles from petr ether, mp 104-105°. LD50 s.c. in rats: 50 mg/kg (Goldenthal).
Melting point: mp 104-105°
Toxicity data: LD50 s.c. in rats: 50 mg/kg (Goldenthal)
Derivative Type: Hydrochloride
CAS Registry Number: 3254-89-5Trademarks: Ansmin (SS Pharm.); Cefadol (Nippon Shinyaku); Celmidol (Tobishi); Difenidolin (Taiyo); Maniol (Morishita); Mecalmin (Yoshitomi); Pineroro (Maruko); Satanolon (Tatsumi); Tenesdol (Hishiyama); Vontrol (SK F); Wansar (Hoei)
Percent Composition: C 72.92%, H 8.16%, N 4.05%, O 4.63%, Cl 10.25%
Properties: Crystals from chloroform + ethyl acetate, mp 212-214°. Freely sol in methanol; sol in water, chloroform. Practically insol in ether, benzene, petr ether.
Melting point: mp 212-214°
Therap-Cat: Antiemetic.
Keywords: Antiemetic.
产品链接: 972-02-1››

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