其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Butaverine CAS Registry Number: 55837-14-4 布他维林

CAS Name: b-Phenyl-1-piperidinepropanoic acid butyl ester
Additional Names: b-phenyl-1-piperidinepropionic acid butyl ester; butyl b-phenyl-1-piperidinepropionate; butyl b-piperidinohydrocinnam...
Literature References: Prepn: Pollard, Mattson, J. Am. Chem. Soc. 78, 4089 (1956); Pacheco et al., Bull. Soc. Chim. Fr. 1962, 1379.

Etofylline Nicotinate CAS Registry Number: 13425-39-3 2-(1,2,3,6-四氢-1,3-二甲基-2,6-二氧代-7h-嘌呤-7-基)烟酸乙酯

CAS Name: 3-Pyridinecarboxylic acid 2-(1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-7H-purin-7-yl)ethyl ester
Additional Names: nicotinic acid ester with 7-(2-hydroxyethyl)theophylline; 7-(2-hydro...
Literature References: Prepn: Pongratz, Zirm, Monatsh. Chem. 88, 330 (1957). Pharmacology: Fischbach, Haas, Arzneim.-Forsch. 17, 313 (1967).

Cetiedil CAS Registry Number: 14176-10-4 西替地尔

CAS Name: a-Cyclohexyl-3-thiopheneacetic acid 2-(hexahydro-1H-azepin-1-yl)ethyl ester
Additional Names: a-cyclohexyl-a-(3-thienyl)acetic acid 2-hexamethyleneiminoethyl ester
Percent Composit...
Literature References: Prepn: Pons, Robba, FR 1460571 and Pons et al., FR M5504 (1966, 1967, both to Innothera), C.A. 68, 59429d (1968); 71, 91286c (1969). Prepn and activity: Robba, LeGuen, Chim. Ther. 2, 120 (1967). Antisickling effect: T. Asakura et al., Proc. Natl. Acad. Sci. USA 77, 2955 (1980); L. R. Berkowitz, E. P. Orringer, J. Clin. Invest. 68, 1215 (1981).

Gestonorone Caproate CAS Registry Number: 1253-28-7 己酸各司孕甾醇

CAS Name: 17-[(1-Oxohexyl)oxy]-19-norpregn-4-ene-3,20-dione
Additional Names: 17-hydroxy-19-norpregn-4-ene-3,20-dione hexanoate; 17a-hydroxy-19-norprogesterone caproate; 17b-acetyl-17-hydroxyes...
Literature References: Prepn: Popper et al., Arzneim.-Forsch. 19, 352 (1969); Popper et al., DE 1074582 (1960 to Schering). Pharmacological studies: Junkmann, Anglo-Ger. Med. Rev. 1, 385 (1962). Metabolism: Breuer, Lisboa, Acta Endocrinol. 51, 114 (1966).

Mipafox CAS Registry Number: 371-86-8 丙胺氟磷

CAS Name: N,N'-Bis(1-methylethyl)phosphorodiamidic fluoride
Additional Names: N,N'-diisopropylphosphorodiamidic fluoride; bis(isopropylamino)fluorophosphine oxide
Percent Composition: C 39.5...
Literature References: Prepn: Pound et al., GB 688787 (1953 to Fisons); Heath, J. Chem. Soc. 1956, 3796.

Cadmium Salicylate CAS Registry Number: 19010-79-8 水杨酸镉(一水)

Percent Composition: C 43.49%, H 2.61%, Cd 29.07%, O 24.83%
Literature References: Prepn: Prasad et al., J. Indian Chem. Soc. 35, 267 (1958).

Ioglycamic Acid CAS Registry Number: 2618-25-9 3,3'-[氧基二[(1-氧代-2,1-乙二基)亚氨基]]二[2,4,6-三碘-苯甲酸

CAS Name: 3,3'-[Oxybis[(1-oxo-2,1-ethanediyl)imino]]bis[2,4,6-triiodobenzoic acid]
Additional Names: 3,3'-[oxybis(methylenecarbonylimino)]bis[2,4,6-triiodobenzoic acid]; 3,3'-(diglycoloyldiimin...
Literature References: Prepn: Priewe et al., Ber. 87, 651 (1954); Priewe, Rutkowski, US 2776241; US 2853424 (1957, 1958 both to Schering AG).

Moxastine CAS Registry Number: 3572-74-5 莫沙斯汀

CAS Name: 2-(1,1-Diphenylethoxy)-N,N-dimethylethanamine
Additional Names: a-methylbenzhydryl 2-dimethylaminoethyl ether; a-methyldiphenhydramine; mephenhydramineTrademarks: Alfadryl (Leciva) Literature References: Prepn: Protiva et al., Chem. Listy 43, 257 (1949); CS 86516 (1957), C.A. 53, 1261 (1959); Z. Vejdelek et al., Collect. Czech. Chem. Commun. 49, 2649 (1984).

Sulfosalicylic Acid CAS Registry Number: 97-05-2 5-磺基水杨酸

CAS Name: 2-hydroxy-5-sulfobenzoic acid
Additional Names: 3-carboxy-4-hydroxybenzenesulfonic acid; 5-sulfosalicylic acid; 2-hydroxybenzoic-5-sulfonic acid; salicylsulfonic acid
Percent Compo...
Literature References: Prepn: Pusca et al., Rev. Chim. (Bucharest) 13, no. 1, 49-50 (1962), C.A. 57, 14994b (1962).

Etamiphyllin CAS Registry Number: 314-35-2 7-[2-(二乙氨基)乙基]-1,3-二甲基黄嘌呤

CAS Name: 7-[2-(Diethylamino)ethyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
Additional Names: 7-(2-diethylaminoethyl)theophylline; 7-(2-diethylaminoethyl)-1,3-dimethylxanthine; 1,3-dimethy...
Literature References: Prepn: Quevauviller et al., Bull. Soc. Chim. Biol. 31, 532 (1946); Moussalli et al., GB 669070 (1952); Klosa, Arch. Pharm. 288, 301 (1955). Toxicity data on combinations: Baettig, Arzneim.-Forsch. 21, 354 (1971). Pharmacokinetics, metabolism, and urinary determn in camels: M. Elghazali et al., J. Vet. Pharmacol. Ther. 25, 43 (2002); GC/MS and LC/MS determn in greyhound urine: M. C. Dumasia, P. Teale, J. Pharm. Biomed. Anal. 36, 1085 (2005).