网站主页>>>项目整合精选>>>项目整合精选>>>Cyclizine CAS Registry Number: 82-92-8 1-二苯甲基-4-甲基哌嗪

Cyclizine CAS Registry Number: 82-92-8 1-二苯甲基-4-甲基哌嗪

CAS Name: 1-Diphenylmethyl-4-methylpiperazine
Additional Names: N-benzhydryl-N'-methylpiperazine; N-methyl-N'-benzhydrylpiperazine; (N-benzhydryl)(N'-methyl)diethylenediamineTrademarks: Marzine (GlaxoWellcome); Marezine (Himmel)
Percent Composition: C 81.16%, H 8.32%, N 10.52%

📌 参考资料/链接：
Literature References: Prepn: R. Baltzly et al., J. Org. Chem. 14, 775 (1949); eidem, US 2630435 (1953 to Burroughs Wellcome). Metabolism: R. Kuntzman et al., Ann. N.Y. Acad. Sci. 226, 131 (1973). Physical properties and analysis: S. A. Benezra, Anal. Profiles Drug Subs. 6, 83 (1977). Crystallographic study: V. Bertolasi et al., Acta Crystallogr. B36, 1975 (1980). HPLC determn: R. B. Walker, I. Kanfer, J. Chromatogr. B 672, 172 (1995). Clinical antiemetic efficacy: G. Rowlands, W. J. Currie, Br. J. Clin. Pract. 30, 197 (1976); W. N. Chestnutt et al., Eur. J. Anaesthesiol. 3, 27 (1986).

📄 详细内容

Properties: Light-sensitive crystals from petr ether, mp 105.5-107.5°. uv max (0.1N HCl): 269, 263, 258, 225 (e 540, 742, 694, 11300). Soly in g/ml at 25°: chloroform 1.1; ether 0.17; ethanol 0.17; in mg/ml: water <0.1.
Melting point: mp 105.5-107.5°
Absorption maximum: uv max (0.1N HCl): 269, 263, 258, 225 (e 540, 742, 694, 11300)
Derivative Type: Hydrochloride
CAS Registry Number: 303-25-3
Trademarks: Valoid (Glaxo Wellcome)
Percent Composition: C 71.39%, H 7.66%, N 9.25%, Cl 11.71%
Properties: Crystals, moderately sol in water. Protect from light.
Therap-Cat: Antiemetic.
Therap-Cat-Vet: Antiemetic.
Keywords: Antiemetic.
产品链接: 82-92-8››

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