Desoximetasone CAS Registry Number: 382-67-2 去羟米松
CAS Name: (11b,16a)-9-Fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
Additional Names: 9a-fluoro-16a-methyl-17-desoxyprednisolone; 9a-fluoro-16a-methyl-D1-corticosterone; desoxymethasoneTrademarks: Esperson (HMR); Stiedex LP (Stiefel); Topicort (HMR); Topisolon (HMR)
Percent Composition: C 70.19%, H 7.76%, F 5.05%, O 17.00%
📌 参考资料/链接：
Literature References: Prepn: R. Joly et al., FR 1296544; eidem, US 3099654 (1962, 1963 to Roussel-UCLAF); BE 614196; Kieslich et al., US 3232839 (1962, 1966 to Schering AG); R. Joly et al., Arzneim.-Forsch. 24, 1 (1974). Activity studies: Branceni et al., Steroids 6, 451 (1965); Schröder et al., Arzneim.-Forsch. 24, 3 (1974). NMR data: Lukacs et al., C.R. Seances Acad. Sci. Ser. C 274, 1458 (1972). Review of pharmacology and therapeutic efficacy in dermatoses: R. C. Heel et al., Drugs 16, 302-321 (1978).
📄 详细内容
Properties: Crystals from ethyl acetate, mp 217°. [a]D +109° (chloroform). uv max: 238 nm (e 15750). Sol in alcohol, acetone, chloroform, hot ethyl acetate; slightly sol in ether, benzene. Insol in water, dil aq acids and alkalies.
Melting point: mp 217°
Optical Rotation: [a]D +109° (chloroform)
Absorption maximum: uv max: 238 nm (e 15750)
Therap-Cat: Anti-inflammatory; glucocorticoid.
Keywords: Glucocorticoid.
产品链接: 382-67-2››