其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Tripelennamine CAS Registry Number: 91-81-6 曲吡那敏

CAS Name: N,N-Dimethyl-N'-(phenylmethyl)-N'-2-pyridinyl-1,2-ethanediamine
Additional Names: 2-[benzyl(2-dimethylaminoethyl)amino]pyridine; N-benzyl-N',N'-dimethyl-N-(2-pyridyl)ethylenediamine; ...
Literature References: Prepn: C. P. Huttrer et al., J. Am. Chem. Soc. 68, 1999 (1946); C. Djerassi et al., US 2406594 (1946 to Ciba); R. J. Horclois, US 2502151 (1950 to Rhône-Poulenc). Crystal structure: M. Parvez, Acta Crystallogr. C43, 1408 (1987). Toxicity studies: D. P. Waller et al., Clin. Toxicol. 16, 17 (1980). Comprehensive description: H. G. Piskorik, Anal. Profiles Drug Subs. 14, 108-133 (1985).

Dimethoxane CAS Registry Number: 828-00-2 2,6-二甲基-1,3-二恶烷-4-醇乙酸酯

CAS Name: 2,6-Dimethyl-1,3-dioxan-4-ol acetate
Additional Names: 6-acetoxy-2,4-dimethyl-m-dioxane; 2,6-dimethyl-m-dioxan-4-yl acetate; acetomethoxane
Trademarks: Dioxin (obsolete); Giv-Gard ...
Literature References: Prepn: C. S. Marvel et al., J. Org. Chem. 4, 252 (1939); Späth et al., Ber. 76, 57 (1943). Description: Am. Perfum. Cosmet. 77, no. 12, 32-34 (1962), C.A. 58, 8848c (1963).

Propiverine CAS Registry Number: 60569-19-9 丙哌维林

CAS Name: a-Phenyl-a-propoxybenzeneacetic acid 1-methyl-4-piperidinyl ester
Additional Names: a,a-diphenyl-a-propoxyacetic acid 1-methyl-4-piperidyl ester; 1-methyl-4-piperidyl diphenylpropoxya...
Literature References: Prepn: C. Starke et al., DD 106643 (1974), C.A. 82, 155841s (1975). GC-MS determn in plasma and urine: T. Marunaka et al., J. Chromatogr. 420, 43 (1987). Pharmacology: A. Haruno, Arzneim.-Forsch. 42, 815, 1459 (1992). Acute toxicity: K. Yamashita et al., J. Toxicol. Sci. 14, Suppl. 2, 1 (1989), C.A. 112, 172060 (1990). Clinical pharmacokinetics: C. Müller et al., Eur. J. Drug Metab. Pharmacokinet. 18, 265 (1993). Clinical trial in urinary incontinence: D. Mazur et al., Urologe A33, 447 (1994).

Bendroflumethiazide CAS Registry Number: 73-48-3 苄氟噻嗪

CAS Name: 3,4-Dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Additional Names: 3-benzyl-6-trifluoromethyl-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benz...
Literature References: Prepn: C. T. Holdrege et al., J. Am. Chem. Soc. 81, 4807 (1959); F. Lund, W. O. Godtfredsen, GB 863474; eidem, US 3392168 (1961, 1968 both to Lövens Kemiske Fabrik). Comprehensive description: K. Florey, F. M. Russo-Alesi, Anal. Profiles Drug Subs. 5, 1-19 (1976).

Sulfarsphenamine CAS Registry Number: 618-82-6 硫胂凡纳明

CAS Name: [1,2-Diarsenediylbis[(6-hydroxy-3,1-phenylene)imino]]bismethanesulfonic acid disodium salt
Additional Names: disodium 3,3'-diamino-4,4'-dihydroxyarsenobenzene N-dimethylenesulfonate; ...
Literature References: Prepn: C. Voegtlin, J. M. Johnson, J. Am. Chem. Soc. 44, 2573 (1922); W. J. C. Dyke, H. King, J. Chem. Soc. 1935, 1745.

Sulfamethazine CAS Registry Number: 57-68-1 磺胺二甲嘧啶

CAS Name: 4-Amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide
Additional Names: N1-(4,6-dimethyl-2-pyrimidinyl)sulfanilamide; N1-(4,6-dimethyl-2-pyrimidyl)sulfanilamide; 4,6-dimethyl-2-sul...
Literature References: Prepn: Caldwell et al., J. Am. Chem. Soc. 63, 2188 (1941); Roblin et al., ibid. 64, 567 (1942); Weisner, Katscher, GB 546158 (1942 to Ward, Blenkinsop); Sprague, US 2407966 (1946 to Sharp Dohme). Alternate prepn: Haworth, Rose, GB 552887 (1943 to I.C.I.); Garzia, US 3119818 (1964 to Ist. Chemioterap. Ital.). Anticoccidiosis activity: Zarin, Feodorova, C.A. 66, 114, 435p-436q (1967). Metabolic studies: Turco et al., Clin. Pharmacol. Ther. 7, 603 (1966); Parker et al., Hum. Hered. 19, 402 (1969). Solubility studies: Shkadova et al., Farm. Zh. (Kiev) 24, 39 (1969). Acute toxicity: B. Bobranski et al., Arch. Immunol. Ther. Exp. 16, 804 (1968). Comprehensive description: C. Papostephanou, M. Frantz, Anal. Profiles Drug Subs. 7, 401-422 (1978).

Prolonium Iodide CAS Registry Number: 123-47-7 普鲁碘胺

CAS Name: 2-Hydroxy-N,N,N,N',N',N'-hexamethyl-1,3-propanediaminium diiodide
Additional Names: (2-hydroxytrimethylene)bis[trimethylammonium] iodide; 1,3-bis(trimethylamino)-2-propanol diiodide; ...
Literature References: Prepn: Callsen, US 1526627 (1925).

Formocortal CAS Registry Number: 2825-60-7 福莫可他

CAS Name: (11b,16a)-21-(Acetyloxy)-3-(2-chloroethoxy)-9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-20-oxopregna-3,5-diene-6-carboxaldehyde
Additional Names: 3-(2-chloroethoxy)-9-flu...
Literature References: Prepn: Camerino et al., FR 1396602 C.A. 63, 5713c (1965); NL 6508458; US 3314945 (1965, 1966, 1967 all to Farmitalia); Baldratti et al., Experientia 22, 468 (1966). Pharmacology: Suchowsky, Baldratti, Proc. 2nd Int. Congr. Horm. Steroids 1966, L. Martini, F. Fraschini, M. Motta, Eds. (Excerpta Medica Found., Amsterdam, 1967) pp 536-540; Tajima, Otsu, Jpn. J. Pharmacol. 62, 115 (1966), C.A. 67, 72329v (1967); Baldratti et al., Arzneim.-Forsch. 21, 1533 (1971). Toxicity studies: Bertazzoli et al., J. Eur. Toxicol. 4, 88 (1971).

Oxabolone CAS Registry Number: 4721-69-1 4-羟基诺龙

CAS Name: (17b)-4,17-Dihydroxyestr-4-en-3-one
Additional Names: 4-hydroxy-19-nortestosterone; 19-norandrost-4-ene-4,17b-diol-3-one
Percent Composition: C 74.45%, H 9.02%, O 16.53%
Literature References: Prepn: Camerino et al., US 2999870 and US 3145201 (1961, 1964, both to Farmitalia). Prepn of the cypionate: Camerino, Patelli, GB 879622 and US 3020295 (1961, 1962, both to Farmitalia).

Clostebol CAS Registry Number: 1093-58-9 氯司替勃

CAS Name: (17b)-4-Chloro-17-hydroxyandrost-4-en-3-one
Additional Names: 4-chlorotestosterone
Percent Composition: C 70.68%, H 8.43%, Cl 10.98%, O 9.91%
Literature References: Prepn: Camerino et al., Farmaco Ed. Sci. 11, 586 (1956); eidem, J. Am. Chem. Soc. 78, 3540 (1956); Ringold et al., J. Org. Chem. 21, 1432 (1956); Camerino, US 2953582 (1960 to Farmitalia); Julian, Printy, US 2933510 (1960 to Julian Labs.). Clinical pharmacology of the acetate: Molinatti et al., Folia Endocrinol. 14, 528 (1961); Krueskemper, Morgner, Int. Z. Klin. Pharmakol. Ther. Toxikol. 1, 455 (1968).