其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Acetyl Sulfamethoxypyrazine CAS Registry Number: 3590-05-4 醋磺胺林

CAS Name: N-[(4-Aminophenyl)sulfonyl]-N-(3-methoxypyrazinyl)acetamide
Additional Names: N1-acetyl-N1-(3-methoxypyrazinyl)sulfanilamide; 2-(N1-acetylsulfanilamido)-3-methoxypyrazine
Trademark...
Literature References: Prepn: Camerino, Palamidessi, Gazz. Chim. Ital. 90, 1815 (1960); eidem, US 3098069 (1963 to Soc. Farmaceutici Italia).

p-Cresotic Acid CAS Registry Number: 89-56-5 5-甲基水杨酸

CAS Name: 2-Hydroxy-5-methylbenzoic acid
Additional Names: 2,5-cresotic acid; p-homosalicylic acid; p-cresotinic acid; 6-hydroxy-m-toluic acid
Percent Composition: C 63.15%, H 5.30%, O 31.55...
Literature References: Prepn: Cameron et al., J. Org. Chem. 15, 233 (1950); Baine et al., ibid. 19, 510 (1954); Thomas et al., J. Am. Chem. Soc. 80, 5864 (1958); Blicke, McCarty, J. Org. Chem. 24, 1061 (1959).

Thenyldiamine CAS Registry Number: 91-79-2 西尼二胺

CAS Name: N,N-Dimethyl-N'-2-pyridinyl-N'-(3-thienylmethyl)-1,2-ethanediamine
Additional Names: 2-[(2-dimethylaminoethyl)-3-thenylamino]pyridine; N,N-dimethyl-N'-(a-pyridyl)-N'-(3-methylthienyl)...
Literature References: Prepn: Campaigne, LeSuer, J. Am. Chem. Soc. 71, 333 (1949). Toxicity study: Hoppe, Lands, J. Pharmacol. Exp. Ther. 97, 371 (1949).

Formebolone CAS Registry Number: 2454-11-7 甲酰勃龙

CAS Name: 11a,17b-Dihydroxy-17-methyl-3-oxoandrosta-1,4-diene-2-carboxaldehyde
Additional Names: 2-formyl-17a-methylandrosta-1,4-diene-11a,17b-diol-3-one; 2-formyl-11a-hydroxy-D1-methyltestoste...
Literature References: Prepn: Canonica et al., Gazz. Chim. Ital. 95, 138 (1968); Gomarasca, GB 1168931; FR 1584960 (1969, 1970 both to Lab. Prod. Biol. Braglia), C.A. 72, 90742g (1970); 73, 131212a (1970). Pharmacology: idem, Minerva Med. 62, 842 (1971); Vaccari, Livini, ibid. 846; De Marchi et al., Arzneim.-Forsch. 23, 1583 (1973). GC/MS determn of metabolites in urine: R. Massé et al., Anal. Chim. Acta 247, 211 (1991). Toxicological studies: Travella, Gazz. Int. Med. Chir. 76, 400 (1971), C.A. 75, 30792a (1971).

Fencibutirol CAS Registry Number: 5977-10-6 羟苯环巳丁酸

CAS Name: a-Ethyl-1-hydroxy-4-phenylcyclohexaneacetic acid
Additional Names: a-(1-hydroxy-4-phenylcyclohexyl)butyric acidTrademarks: Biligen; Hepasil; Verecolene
Percent Composition: C 73.25...
Literature References: Prepn: Carissimi, Ravenna, US 3027302 (1962 to Maggioni).

Emepronium Bromide CAS Registry Number: 3614-30-0 依美溴铵

CAS Name: N-Ethyl-N,N,a-trimethyl-g-phenylbenzenepropanaminium bromide
Additional Names: ethyldimethyl(1-methyl-3,3-diphenylpropyl)ammonium bromide; ethyl(3,3-diphenyl-1-methylpropyl)dimethylam...
Literature References: Prepn: Carlsson, SE 136606 (1952 to Aktiebolaget Recip.), C.A. 48, 729a (1954).

Neocuproine CAS Registry Number: 484-11-7 新铜试剂

CAS Name: 2,9-Dimethyl-1,10-phenanthroline
Additional Names: 2,9-dimethyl-o-phenanthroline
Percent Composition: C 80.74%, H 5.81%, N 13.45%
Literature References: Prepn: Case, J. Am. Chem. Soc. 70, 3994 (1948); O'Reilly, Plowman, Aust. J. Chem. 13, 145 (1960).

Iomeglamic Acid CAS Registry Number: 25827-76-3 碘美拉酸

CAS Name: 5-[(3-Amino-2,4,6-triiodophenyl)methylamino]-5-oxopentanoic acid
Additional Names: 3'-amino-2',4',6'-triiodo-N-methylglutaranilic acid; N-methyl-N-(3-amino-2,4,6-triiodophenyl)glutara...
Literature References: Prepn: Cassebaum, Dierbach, DD 67209 (1969), C.A. 72, 66654j (1970). Biotransformation: Pfeifer et al., Pharmazie 27, 403 (1972). Pharmacology: H. Bekker et al., ibid. 411. Clinical evaluation: Barke, Zentralbl. Pharm. Pharmakother. Laboratoriumsdiagn. 110, 1117 (1971).

Bunamiodyl Sodium CAS Registry Number: 1923-76-8 丁酸,2-[[2,4,6-三碘-3-[(1-氧代丁基)氨基]苯基],钠盐(1:1)

CAS Name: 2-[[2,4,6-Triiodo-3-[(1-oxobutyl)amino]phenyl]methylene]butanoic acid monosodium salt
Additional Names: 3-butyramido-a-ethyl-2,4,6-triiodocinnamic acid sodium salt; 3-(3-butyrylamino-...
Literature References: Prepn: Cassebaum, Dierbach, Pharmazie 16, 389 (1961). Acute toxicity: J. O. Hoppe et al., J. Med. Chem. 13, 997 (1970).

Clorindione CAS Registry Number: 1146-99-2 氯茚二酮

CAS Name: 2-(4-Chlorophenyl)-1H-indene-1,3(2H)-dione
Additional Names: 2-(p-chlorophenyl)-1,3-indandione; 2-(4-chlorophenyl)indan-1,3-dione; chlophenadioneTrademarks: Indaliton (Geigy)
Perce...
Literature References: Prepn: Cavallini et al., Farmaco Ed. Sci. 10, 710 (1955); GB 748251 (1956 to Geigy). Pharmacokinetics: Danek, Pogonowska-Wala, Pol. J. Pharmacol. Pharm. 25, 307 (1973), C.A. 79, 111540b (1973). Toxicity study: Fontaine et al., Med. Pharmacol. Exp. 17, 497 (1967).