其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Bromindione CAS Registry Number: 1146-98-1 溴茚二酮

CAS Name: 2-(4-Bromophenyl)-1H-indene-1,3(2H)-dione
Additional Names: 2-(4-bromophenyl)-1,3-dioxohydrindeneTrademarks: Fluidane; Halinone (USV)
Percent Composition: C 59.83%, H 3.01%, Br 26....
Literature References: Prepn: Cavallini et al., Farmaco Ed. Sci. 10, 710 (1955); Freedman et al., US 2847474 (1958 to U.S. Vitamin).

Amphecloral CAS Registry Number: 5581-35-1 胺苯氯醛

CAS Name: a-Methyl-N-(2,2,2-trichloroethylidene)benzeneethanamine
Additional Names: a-methyl-N-(2,2,2-trichloroethylidene)phenethylamine; N-[2-(1-phenylpropyl)]-2,2,2-trichloroethylidenimine; a...
Literature References: Prepn: Cavallito, US 2923661 (1960 to Irwin, Neisler).

Methoxypromazine CAS Registry Number: 61-01-8 美索丙嗪

CAS Name: 2-Methoxy-N,N-dimethyl-10H-phenothiazine-10-propanamine
Additional Names: 10-(3-dimethylaminopropyl)-2-methoxyphenothiazine; 3-methoxy-10-(3'-dimethylaminopropyl)phenothiazine; 2-meth...
Literature References: Prepn: Charpentier et al., Compt. Rend. 235, 59 (1952); R. M. Jacob, J. G. Robert, US 2785160 (1957 to Rhone-Poulenc).

Isopromethazine CAS Registry Number: 303-14-0 N,N-二甲基-2-(10H-吩噻嗪-10-基)丙-1-胺

CAS Name: N,N,b-Trimethyl-10H-phenothiazine-10-ethanamine
Additional Names: 10-(2-dimethylamino-1-methylethyl)phenothiazine; 10-(2-dimethylaminoisopropyl)phenothiazine; isomethazineTrademarks: ...
Literature References: Prepn: Charpentier, Compt. Rend. 225, 306 (1947); Charpentier, Ducrot, ibid. 232, 415 (1951); Charpentier et al., ibid. 2232; Berg, Ashley, US 2607773 (1952 to Rhône-Poulenc); Edge, Wragg, J. Pharm. Pharmacol. 5, 279 (1953).

Metyrapone CAS Registry Number: 54-36-4 美替拉酮

CAS Name: 2-Methyl-1,2-di-3-pyridyl-1-propanone
Additional Names: 2-methyl-1,2-bis(3-pyridyl)-1-propanone; methopyrapone; mepyrapone; metopyrone; methbipyranoneTrademarks: Metopiron(e) (Novarti...
Literature References: Prepn: Chart et al., Experientia 14, 151 (1958); W. L. Bencze, M. J. Allen, J. Am. Chem. Soc. 81, 4015 (1959); eidem, US 2966493 (1960 to Ciba).

Dinsed CAS Registry Number: 96-62-8 对碘苯甲醚

CAS Name: N,N'-1,2-Ethanediylbis[3-nitrobenzenesulfonamide]
Additional Names: N,N'-ethylenebis[3-nitrobenzenesulfonamide]; N,N'-ethylenebis[m-nitrobenzenesulfonamide]; N,N'-bis[3-nitrobenzenesu...
Literature References: Prepn: Chattaway, J. Chem. Soc. 87, 381 (1905).

Phenyltoloxamine CAS Registry Number: 92-12-6 苯托沙敏

CAS Name: N,N-Dimethyl-2-[2-(phenylmethyl)phenoxy]ethanamine
Additional Names: N,N-dimethyl-2-(a-phenyl-o-tolyloxy)ethylamine; N,N-dimethyl-2-(a-phenyl-o-toloxy)ethylamine; 2-(2-dimethylaminoet...
Literature References: Prepn: Cheney et al., J. Am. Chem. Soc. 71, 60 (1949); Binkley, Cheney, US 2703324 (1955 to Bristol Labs.).

Lysidine CAS Registry Number: 534-26-9 2-甲基咪唑啉

CAS Name: 4,5-Dihydro-2-methyl-1H-imidazole
Additional Names: 2-methyl-2-imidazoline; methylglyoxalidine
Percent Composition: C 57.11%, H 9.59%, N 33.30%
Literature References: Prepn: Chitwood, Reid, J. Am. Chem. Soc. 57, 2424 (1935); King, McMillan, ibid. 68, 1774 (1946); Kyrides, US 2392326 and US 2404299 (both 1946 to Monsanto); Ahrens, US 2813862 (1957 to Organon).

Parethoxycaine CAS Registry Number: 94-23-5 2-二乙基氨基乙基 4-乙氧基苯甲酸酯

CAS Name: 4-Ethoxybenzoic acid 2-(diethylamino)ethyl ester
Additional Names: b-diethylaminoethyl p-ethoxybenzoate; diethoxin
Percent Composition: C 67.90%, H 8.74%, N 5.28%, O 18.09%
Literature References: Prepn: Christiansen, Harris, US 2404691 (1946 to Squibb).

Sulfamethoxypyridazine CAS Registry Number: 80-35-3 磺胺甲氧哒嗪

CAS Name: 4-Amino-N-(6-methoxy-3-pyridazinyl)benzenesulfonamide
Additional Names: N1-(6-methoxy-3-pyridazinyl)sulfanilamide; 6-methoxy-3-sulfanilamidopyridazine; 3-(p-aminobenzenesulfamido)-6-m...
Literature References: Prepn: Clark, US 2712012 (1955 to Am. Cyanamid). Toxicity: Seki et al., Arzneim.-Forsch. 15, 1441 (1965). Toxicological, chemotherapeutic and pharmacokinetic studies: Böhni et al., Chemotherapy 14, 195-226 (1969).