其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Diethyl Oxalate CAS Registry Number: 95-92-1 草酸二乙酯

CAS Name: Ethanedioic acid diethyl ester
Additional Names: ethyl oxalate; diethyl ethanedioate; oxalic acid diethyl ester
Percent Composition: C 49.31%, H 6.90%, O 43.79%
Literature References: Prepn: Clarke, Davis, Org. Synth. coll. vol. I, 256 (2nd ed., 1941); Kenyon, ibid. 261.

Chlorazanil CAS Registry Number: 500-42-5 氯拉扎尼

CAS Name: N-(4-Chlorophenyl)-1,3,5-triazine-2,4-diamine
Additional Names: 2-amino-4-(p-chloroanilino)-s-triazine; N-(p-chlorophenyl)-2,4-diamino-s-triazine; 2-(p-chloroanilino)-4-amino-s-triazi...
Literature References: Prepn: Clauder, Bulcsu, Magy. Kem. Foly. 57, 68 (1951), C.A. 46, 4023g (1952); AT 168063 (1951) and GB 676024 (1952), C.A. 47, 8097g, 3887i (1953). Synthesis and diuretic activity: Shah et al., J. Med. Chem. 11, 1167 (1968). See also Takagi, Ueda, Chem. Pharm. Bull. 17, 1061 (1969).

Stanozolol CAS Registry Number: 10418-03-8 (2 ¢ H form); 302-96-5 (1 ¢ H form)

CAS Name: (5a,17b)-17-Methyl-2'H-androst-2-eno[3,2-c]pyrazol-17-ol
Additional Names: 1,2,3,3a,3b,4,5,5a,6,8,10,10a,10b,11,12,12a-hexadecahydro-1,10a,12a-trimethylcyclopenta[7,8]phenanthro[2,3-c...
Literature References: Prepn: Clinton et al., J. Am. Chem. Soc. 81, 1513 (1959); 83, 1478 (1961); Manson, US 3030358 (1962 to Sterling Drug).

Propoxycaine Hydrochloride CAS Registry Number: 550-83-4 丙氧卡因盐酸盐

CAS Name: 4-Amino-2-propoxybenzoic acid 2-diethylaminoethyl ester hydrochloride
Additional Names: 2-diethylaminoethyl 4-amino-2-propoxybenzoate hydrochloride; 2-diethylaminoethyl 2-propoxy-4-am...
Literature References: Prepn: Clinton, Laskowski, US 2689248 (1954 to Sterling Drug).

Methyclothiazide CAS Registry Number: 135-07-9 甲氯噻嗪

CAS Name: 6-Chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Additional Names: 6-chloro-3-chloromethyl-3,4-dihydro-2-methyl-7-sulfamoyl-1,2,4-ben...
Literature References: Prepn: Close et al., J. Am. Chem. Soc. 82, 1132 (1960). Description: Ford, Curr. Ther. Res. 2, 422 (1960). Comprehensive description: J. A. Raihle, Anal. Profiles Drug Subs. 5, 307-326 (1976).

Teclothiazide CAS Registry Number: 4267-05-4 四氯噻嗪

CAS Name: 6-Chloro-3,4-dihydro-3-trichloromethyl-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Additional Names: 6-chloro-3,4-dihydro-7-sulfamoyl-3-trichloromethyl-2H-1,2,4-benzothiadiazi...
Literature References: Prepn: Close et al., J. Am. Chem. Soc. 82, 1132 (1960); Novello et al., J. Org. Chem. 25, 970 (1960). Pharmacology and toxicology: M. Auclair et al., Therapie 18, 131, 137 (1963).

Chlorphenesin Carbamate CAS Registry Number: 886-74-8 氯苯氨酸甘油酯

CAS Name: 3-(4-Chlorophenoxy)-1,2-propanediol-1-carbamate
Additional Names: carbamic acid 3-(p-chlorophenoxy)-2-hydroxypropyl ester; 3-(p-chlorophenoxy)-2-hydroxypropyl carbamate; 1,2-propanedi...
Literature References: Prepn: Collins, Matthews, US 3161567; Parker, US 3214336 (1964, 1965 both to Upjohn). Clinical evaluation of analgesic activity: L. J. Cass, W. S. Frederick, J. New Drugs 2, 366 (1962).

Naphthol Yellow S CAS Registry Number: 846-70-8 黄胺酸二钠盐

CAS Name: 8-Hydroxy-5,7-dinitro-2-naphthalenesulfonic acid disodium salt
Additional Names: Citronin A; Sulfur Yellow S; Acid Yellow S; FD C Yellow no. 1; Ext. D C Yellow no. 7; C.I. Acid Yell...
Literature References: Prepn: Colour Index vol. 4 (3rd ed., 1971) p 4004.

p-Dimethylaminoazobenzene CAS Registry Number: 60-11-7 二甲基黄

CAS Name: N,N-Dimethyl-4-(phenylazo)benzenamine
Additional Names: butter yellow; methyl yellow; C.I. Solvent Yellow 2; C.I. 11020
Percent Composition: C 74.64%, H 6.71%, N 18.65%
Literature References: Prepn: Colour Index vol. 4 (3rd ed., 1971) p 4014. Review of carcinogenic risk: IARC Monographs 8, 125-146 (1975).

Norvinisterone CAS Registry Number: 6795-60-4 诺乙烯酮

CAS Name: (17a)-17-Hydroxy-19-norpregna-4,20-dien-3-one
Additional Names: 17-hydroxy-17a-vinyl-4-estren-3-one; 17-hydroxy-13-methyl-17a-vinyl-1,2,3,6,7,8,9,10,11,12,13,14,16,17-tetradecahydro-1...
Literature References: Prepn: Colton, US 2655518; US 2802015 (both 1953 to Searle).