其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Methotrimeprazine CAS Registry Number: 60-99-1 左美吗嗪

CAS Name: (bR)-2-Methoxy-N,N,b-trimethyl-10H-phenothiazine-10-propanamine
Additional Names: (-)-10-(3-dimethylamino-2-methylpropyl)-2-methoxyphenothiazine; levomepromazine; 2-methoxytrimeprazin...
Literature References: Prepn: Courvoisier et al., C.R. Seances Soc. Biol. Ses Fil. 151, 1378 (1957); Jacob, Robert, US 2837518 (1958 to Rhône-Poulenc).

Trifluoperazine CAS Registry Number: 117-89-5 三氟拉嗪

CAS Name: 10-[3-(4-Methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-10H-phenothiazine
Additional Names: 2-trifluoromethyl-10-[3'-(1-methyl-4-piperazinyl)propyl]phenothiazine
Percent Composit...
Literature References: Prepn: Craig et al., J. Org. Chem. 22, 709 (1957); GB 813861; G. E. Ullyot, US 2921069 (1959 and 1960 to SK F). Metabolism: T. L. Flanagan et al., J. Pharm. Sci. 51, 996 (1962); C. L. Huang, K. G. Bhansali, ibid. 57, 1511 (1968). Toxicity: P. J. Fowler et al., Arzneim.-Forsch. 27, 866 (1977). Comprehensive description: A. Post et al., Anal. Profiles Drug Subs. 9, 543-581 (1980).

Diglyme CAS Registry Number: 111-96-6 二乙二醇二甲醚

CAS Name: 1,1'-Oxybis[2-methoxyethane]
Additional Names: bis(2-methoxyethyl) ether; diethylene glycol dimethyl ether
Percent Composition: C 53.71%, H 10.52%, O 35.77%
Literature References: Prepn: Cretcher, Pittenger, J. Am. Chem. Soc. 47, 163 (1925); Gallaugher, Hibbert, ibid. 58, 813 (1936).

Sulfazamet CAS Registry Number: 852-19-7 磺胺吡唑

CAS Name: 4-Amino-N-(3-methyl-1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide
Additional Names: N1-(3-methyl-1-phenylpyrazol-5-yl)sulfanilamide; 5-(p-aminobenzenesulfonamido)-3-methyl-1-phenylpyraz...
Literature References: Prepn: Crippa, Guarneri, Gazz. Chim. Ital. 85, 199 (1955); GB 848627 (1960 to Ciba); Seydel, Krueger-Theimer, Arzneim.-Forsch. 14, 1294 (1964). Amino-imino tautomerism: eidem, ibid.

N-Acetylpenicillamine CAS Registry Number: 15537-71-0 N-乙酰基-D-青霉胺

CAS Name: N-Acetyl-3-mercapto-D-valine
Percent Composition: C 43.96%, H 6.85%, N 7.32%, O 25.10%, S 16.77%
Literature References: Prepn: Crooks in The Chemistry of Penicillin (Princeton Univ. Press, 1949) p 470; Sheehan et al., US 2477148 and US 2496416 (1949, 1950, both to Merck Co.).

Sulfabenzamide CAS Registry Number: 127-71-9 磺胺苯甲酰

CAS Name: N-[(4-Aminophenyl)sulfonyl]benzamide
Additional Names: N-sulfanilylbenzamide; N1-benzoylsulfanilamide; N-(p-aminobenzenesulfonyl)benzamide
Trademarks: Sulfabenzide
Percent Compo...
Literature References: Prepn: Crossley et al., J. Am. Chem. Soc. 61, 2950 (1939); Dvornikoff, US 2240496 (1941 to Monsanto); GB 541958 (1942 to Schering AG); Siebenmann, Schnitzer, J. Am. Chem. Soc. 65, 2126 (1943).

Nicarbazin CAS Registry Number: 330-95-0 尼卡巴嗪

CAS Name: N,N'-Bis(4-nitrophenyl)urea, compd with 4,6-dimethyl-2(1H)-pyrimidinone (1:1)
Additional Names: 4,4'-dinitrocarbanilide compd with 4,6-dimethyl-2-pyrimidinol (1:1)
Trademarks: Nica...
Literature References: Prepn: Cuckler et al., Science 122, 244 (1955); Basso, O'Neill, US 2731382; US 2731383; US 2731384 (all 1956 to Merck Co.). Effect on nutritional encephalopathy in chicks: I. Bartov, P. Budowski, Poult. Sci. 58, 597 (1979).

Pipamazine CAS Registry Number: 84-04-8 匹哌马嗪

CAS Name: 1-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-4-piperidinecarboxamide
Additional Names: 1-[3-(2-chlorophenothiazin-10-yl)propyl]isonipecotamide; 10-[3-(4-carbamoylpiperidin-1-yl)propy...
Literature References: Prepn: Cusic et al., US 2957870 (1960 to Searle).

Dimenhydrinate CAS Registry Number: 523-87-5 茶苯海明

CAS Name: 8-Chloro-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione compd with 2-(diphenylmethoxy)-N,N-dimethylethanamine (1:1)
Additional Names: 2-(benzhydryloxy)-N,N-dimethylethylamine 8-chloroth...
Literature References: Prepn: Cusic, Science 109, 574 (1949); Cusic, US 2499058 and US 2534813 (1950 to Searle).

Laurolinium Acetate CAS Registry Number: 146-37-2 醋酸劳利铵

CAS Name: 4-Amino-1-dodecyl-2-methylquinolinium acetate
Additional Names: 4-amino-1-dodecylquinaldinium acetate; 1-dodecyl-4-aminoquinaldinium acetate
Trademarks: Laurodin
Percent Composi...
Literature References: Prepn: D. Caldwell et al., J. Pharm. Pharmacol. 13, 554 (1961); D. Caldwell, L. R. Rowe, US 2997476 (1961 to Allen Hanburys). Toxicity data: W. A. Cox, P. F. D'Arcy, J. Pharm. Pharmacol. 15, 129 (1963).