其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Bethanechol Chloride CAS Registry Number: 590-63-6 氯贝胆碱

CAS Name: 2-[(Aminocarbonyl)oxy]-N,N,N-trimethyl-1-propanaminium chloride
Additional Names: (2-hydroxypropyl)trimethylammonium chloride carbamate; 2-carbamoyloxypropyltrimethylammonium chloride...
Literature References: Prepn: Dalmer, Diehl, US 1894162 (1933); Major, Bonnett, US 2322375 (1943 to Merck Co.). 1H-NMR determn in tablets: G. M. Hanna, C. A. Lau-Cam, J. Assoc. Off. Anal. Chem. 70, 557 (1987). Clinical trial in postoperative urinary retention: L. Gottesman et al., Dis. Colon Rectum 32, 867 (1989).

Dibromochloropropane CAS Registry Number: 96-12-8 1,2-二溴-3-氯丙烷

CAS Name: 1,2-Dibromo-3-chloropropane
Additional Names: 3-chloro-1,2-dibromopropane; DBCPTrademarks: Fumazone; Nemafume; Nemagon
Percent Composition: C 15.25%, H 2.13%, Br 67.62%, Cl 15.00%
Literature References: Prepn: Darmstädter, Ann. 152, 320 (1869). Activity: C. W. McBeth, G. B. Bergeson, Plant Dis. Rep. 39, 223 (1955). Toxicity study: T. R. Torkelson et al., Toxicol. Appl. Pharmacol. 3, 545 (1961). Carcinogenicity studies: W. A. Olsen et al., J. Natl. Cancer Inst. 51, 1993 (1973); E. K. Weisburger, Environ. Health Perspect. 21, 7 (1977). Mutagenicity study: H. S. Rosenkranz, Bull. Environ. Contam. Toxicol. 14, 8 (1975). Review of toxicology and human exposure: Toxicological Profile for 1,2-Dibromo-3-chloropropane (PB93-110906, 1992) 164 pp.

Versalide® (Givaudan-Delawanna) CAS Registry Number: 88-29-9 7-乙酰基-6-乙基-1,2,3,4-四氢-1,1,4,4-四甲基萘

CAS Name: 1-(3-Ethyl-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethanone
Additional Names: 3'-ethyl-5',6',7',8'-tetrahydro-5',5',8',8'-tetramethyl-2'-acetonaphthone
Percent Compos...
Literature References: Prepn: Davidson, Lusskin, US 3045047 (1962 to Trubek Lab.). GC determn in fragrances: H. H. Wisneski et al., J. Assoc. Off. Anal. Chem. 65, 598 (1982). Toxicity: K. R. Butterworth, P. L. Mason, Food Cosmet. Toxicol. 19, 753 (1981).

Aloxidone CAS Registry Number: 526-35-2 阿洛双酮

CAS Name: 5-Methyl-3-(2-propenyl)-2,4-oxazolidinedione
Additional Names: 3-allyl-5-methyl-2,4-oxazolidinedione; allomethadione
Trademarks: Malidone (Schering); Malazol
Percent Composition...
Literature References: Prepn: Davies, Hook, GB 627971; GB 632423 (1949 to British Schering).

Ethadione CAS Registry Number: 520-77-4 依沙双酮

CAS Name: 3-Ethyl-5,5-dimethyl-2,4-oxazolidinedione
Additional Names: 3-ethyl-5,5-dimethyl-2,4-diketooxazolidine
Trademarks: Petidiol; Didione; Petidion (Gerot); Epinyl (Nordic); Etydion (No...
Literature References: Prepn: Davis, Hook, GB 626971 (1949 to Brit. Schering Res. Labs.).

Hydrochlorothiazide CAS Registry Number: 58-93-5 氢氯噻嗪

CAS Name: 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Additional Names: 6-chloro-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide; 6-chloro-7-sulfamyl-...
Literature References: Prepn: de Stevens et al., Experientia 14, 463 (1958); Werner et al., J. Am. Chem. Soc. 82, 1161 (1960); Jones, Novello, US 3025292 (1962 to Merck Co.); de Stevens, Werner, US 3163645 (1964 to Ciba); Klosa, DE 1163332 (1964); J. S. Irons, T. M. Cook, US 3164588 (1965 to Merck Co.). Purification: Downing, US 3043840 (1962 to Merck Co.). Toxicity data: J. J. Piala et al., J. Pharmacol. Exp. Ther. 134, 273 (1961). Comprehensive description: H. P. Deppeler, Anal. Profiles Drug Subs. 10, 405-441 (1981).

Lynestrenol CAS Registry Number: 52-76-6 利奈孕醇

CAS Name: (17a)-19-Norpregn-4-en-20-yn-17-ol
Additional Names: 17a-ethinyl-17b-hydroxyestr-4-ene; 17a-ethynylestr-4-en-17b-ol; 3-desoxynorlutin; ethinylestrenol
Trademarks: Exluton(a) (Organ...
Literature References: Prepn: de Winter et al., Chem. Ind. (London) 1959, 905. Metabolism: Kamyab et al., Biochem. J. 103, 14P (1967); J. Endocrinol. 42, 337 (1968). Pharmacokinetics and metabolism: H. Kuhl et al., Contraception 26, 303 (1982). Clinical trial of use in normophasic oral contraceptives: N. Dombrowicz et al., ibid. 22, 537 (1980). Review of carcinogenicity studies: IARC Monographs 21, 407-415 (1979).

Deoxyuridine CAS Registry Number: 951-78-0 2’-脱氧尿苷

CAS Name: 2'-Deoxyuridine
Additional Names: 1-(2-deoxy-b-D-erythro-pentofuranosyl)uracil; 1-(2-deoxy-b-D-ribofuranosyl)uracil; uracil deoxyriboside
Percent Composition: C 47.37%, H 5.30%, N ...
Literature References: Prepn: Dekker, Todd, Nature 166, 557 (1950); Brown et al., J. Chem. Soc. 1958, 3035; Prystas et al., Collect. Czech. Chem. Commun. 28, 3140 (1963); Smejkal et al., ibid. 31, 291 (1966). Conformation: Rahman, Wilson, Nature 232, 333 (1971).

Myoral CAS Registry Number: 645-74-9

CAS Name: Calcium [mercaptoacetato(2-)-O,S]aurate(1-) (1:2)
Additional Names: [(carboxymethyl)thio]gold calcium salt; calcium aurothioglycolate; mercaptoacetic acid calcium salt gold derivative...
Literature References: Prepn: Denko, Anderson, J. Am. Chem. Soc. 67, 2241 (1945). Description: Lespagnol, Pharmacie Chimique (Paris, 3rd ed., 1950) p 941.

Trichlormethiazide CAS Registry Number: 133-67-5 三氯噻嗪

CAS Name: 6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Additional Names: 6-chloro-3-dichloromethyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1...
Literature References: Prepn: deStevens et al., Experientia 16, 113 (1960); Sherlock et al., ibid. 184. Toxicity: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).