其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Kebuzone CAS Registry Number: 853-34-9 酮基保太松

CAS Name: 4-(3-Oxobutyl)-1,2-diphenyl-3,5-pyrazolidinedione
Additional Names: 1,2-diphenyl-4-(g-ketobutyl)-3,5-pyrazolidinedione; 1,2-diphenyl-4-(3'-oxobutyl)-3,5-dioxopyrazolidine; ketophenylb...
Literature References: Prepn: Deuss et al., US 2910481 (1959 to Geigy). Review of pharmacology: Horakova et al., Pharmacotherapeutica 1950-1959, 335-350 (1963), C.A. 60, 6072g (1964). Metabolism: Nemecek et al., Arzneim.-Forsch. 16, 1339 (1966); Queisnerova, Nemecek, Cesk. Farm. 20, 55 (1971), C.A. 75, 47077u (1971).

p-Sulfanilylbenzylamine CAS Registry Number: 4393-19-5 4-{[4-(氨基甲基)苯基]磺酰基}苯胺

CAS Name: 4-[(4-Aminophenyl)sulfonyl]benzenemethanamine
Additional Names: p-sulfanilidobenzylamine; 4-aminomethyl-4'-aminodiphenyl sulfone; p-aminophenyl-p-aminomethylphenyl sulfone
Trademar...
Literature References: Prepn: Dewing, J. Chem. Soc. 1946, 466; Wenner, J. Org. Chem. 22, 1508 (1957).

Butethamate CAS Registry Number: 14007-64-8 布替他酯

CAS Name: Benzeneacetic acid a-ethyl-2-(diethylamino)ethyl ester
Additional Names: 2-phenylbutyric acid 2-(diethylamino)ethyl ester; b-diethylaminoethyl ethylphenylacetate; 2-diethylaminoethyl ...
Literature References: Prepn: Di Paco, Tauro, Farmaco Ed. Sci. 11, 540 (1956); CH 291375 (1953 to AG Hommel's Haematogen) and CH 292596 (1953 to Chem. Fabrik "PARA"), C.A. 49, 2505a,c (1955). Pharmacology: Jordan, Arzneim.-Forsch. 8, 716 (1958); Fleisch et al., ibid. 11, 1119 (1961).

Cadmium Potassium Cyanide CAS Registry Number: 14402-75-6 四氰化镉二钾

CAS Name: Potassium tetracyanocadmate
Percent Composition: C 16.30%, Cd 38.15%, K 26.54%, N 19.01%
Literature References: Prepn: Dickinson, J. Am. Chem. Soc. 44, 774 (1922); Biltz, Z. Anorg. Allg. Chem. 170, 161 (1928).

Norea CAS Registry Number: 18530-56-8

CAS Name: N,N-Dimethyl-N'-(octahydro-4,7-methano-1H-inden-5-yl)urea
Additional Names: 3-(hexahydro-4,7-methanoindan-5-yl)-1,1-dimethylurea; noruronTrademarks: Herban (Hercules)
Percent Compo...
Literature References: Prepn: Diveley, Pombo, US 3150179 (1964 to Hercules). Microbial degradn: Murray et al., Weed Sci. 17, 52 (1969).

Normethandrone CAS Registry Number: 514-61-4 甲基诺龙

CAS Name: (17b)-17-Hydroxy-17-methylestr-4-en-3-one
Additional Names: 17a-methyl-19-nortestosterone; methylestrenolone; normethandrolone; normetandrone; methylnortestosterone
Trademarks: Org...
Literature References: Prepn: Djerassi et al., US 2744122 and US 2774777 (1956 to Syntex); J. Am. Chem. Soc. 76, 4092 (1956); De Ruggieri, US 2849461 (1958).

Methohexital Sodium CAS Registry Number: 22151-68-4 美索比妥

CAS Name: 1-Methyl-5-(1-methyl-2-pentynyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione sodium salt
Additional Names: 5-allyl-1-methyl-5-(1-methyl-2-pentynyl)barbituric acid sodium salt; a-d...
Literature References: Prepn: Doran, US 2872448 (1959 to Lilly).

Phenylethanolamine CAS Registry Number: 7568-93-6 2-氨基-1-苯基乙醇

CAS Name: a-(Aminomethyl)benzenemethanol
Additional Names: a-(aminomethyl)benzyl alcohol; b-hydroxyphenethylamine
Percent Composition: C 70.04%, H 8.08%, N 10.21%, O 11.66%
Literature References: Prepn: Dornow, Theidel, Ber. 88, 1267 (1955).

Benzoylpas CAS Registry Number: 13898-58-3 4-苯酰胺-2-羟基苯甲酸

CAS Name: 4-(Benzoylamino)-2-hydroxybenzoic acid
Additional Names: N-benzoyl-p-aminosalicylic acid; 4-benzamidosalicylic acid
Percent Composition: C 65.37%, H 4.31%, N 5.44%, O 24.88%
Literature References: Prepn: Drain et al., J. Chem. Soc. 1949, 1498; GB 676363 (1952 to Wander). Prepn of sodium and calcium salts: Suddaby, Sumpter, GB 711163 (1954 to Herst).

p-Aminosalicylic Acid Hydrazide CAS Registry Number: 6946-29-8 4-氨基水杨酰肼

CAS Name: 4-Amino-2-hydroxybenzoic acid hydrazide
Trademarks: Apacizin; Apacizina (Farmitalia)
Percent Composition: C 50.29%, H 5.43%, N 25.14%, O 19.14%
Literature References: Prepn: Drain et al., J. Chem. Soc. 1949, 1498; Magrane, ES 206645 (1952), C.A. 49, 5529e (1955); JP 54 7472 (1954), C.A. 50, 9947c (1956).