其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Titanium Oxysulfate CAS Registry Number: 13825-74-6 硫酸氧钛

CAS Name: Oxo[sulfato(2-)-kO,kO']titanium
Additional Names: titanyl sulfate; titanium sulfate
Percent Composition: O 50.02%, S 20.05%, Ti 29.93%
Literature References: Prepn: E. Hayek, A. Engelbrecht, Monatsh. Chem. 80, 640 (1949). Crystal structure: B. M. Gatehouse et al., Acta Crystallogr. B49, 428 (1993). Catalytic hydrolysis of chlorofluorocarbon: X. Deng et al., J. Catalysis 204, 200 (2001). Prepn of titanium dioxide, q.v.,via thermal hydrolysis: A. V. Tolchev et al., Russ. J. Appl. Chem. 74, 1631 (2001); L. G. Gerasimova et al., ibid. 75, 875 (2002). Sol-gel synthesis of nanosized anatase, a mineral form of titanium dioxide: S. Sivakumar et al., Mater. Lett. 57, 330 (2002). Brief review as whitening agent in tanning: S. Bangaruswamy et al., J. Soc. Leather Technol. Chem. 68, 13-14 (1984).

Azintamide CAS Registry Number: 1830-32-6 阿嗪米特

CAS Name: 2-[(6-Chloro-3-pyridazinyl)thio]-N,N-diethylacetamide
Additional Names: N,N-diethyl-2-[6-(3-chloropyridazinyl)thio]acetamide; N,N-diethyl-2-[6-(3-chloropyridazinyl)mercapto]acetamide;...
Literature References: Prepn: E. Kloimstein et al., Arzneim.-Forsch. 14, 261 (1964); eidem, DE 1188604 (1965 to Lentia). Pharmacology and acute toxicity: H. Stormann, Arzneim.-Forsch. 14, 266 (1964). Toxicology: I. Lindner et al., ibid. 271. Clinical pharmacology: G. Hitzenberger, ibid. 279. Comprehensive description: E. M. Abdel-Moety, H. A. Al-Khamees, Anal. Profiles Drug Subs. 18, 1-32 (1989).

Isophorone CAS Registry Number: 78-59-1 异佛尔酮

CAS Name: 3,5,5-Trimethyl-2-cyclohexen-1-one
Additional Names: a-isophorone; 1,5,5-trimethyl-3-oxocyclohexene; 1,3,3-trimethylcyclohexen-5-one; isoforon; isoacetophorone
Percent Composition:...
Literature References: Prepn: E. Knoevenagel, Ann. 297, 113 (1897). Synthesis: H. Ueda et al., Agric. Biol. Chem. 30, 1004 (1966); D. S. Torok, W. J. Scott, Tetrahedron Lett. 34, 3067 (1993). Colorimetric field test for determn in air: P. Andrew, R. Wood, Analyst 95, 691 (1970). Solid-phase microextraction/GC determn in aq. samples: J.-Y. Horng, S.-D. Huang, J. Chromatogr. A 678, 313 (1994). Brief description: P. D. Sherman, Jr., A. J. Papa in Kirk-Othmer Encyclopedia of Chemical Technology vol. 13 (Wiley-Interscience, New York, 3rd ed., 1981) pp 918-922. Review of prepn and purification: G. S. Salvapati, M. Janardanarao, J. Sci. Ind. Res. 42, 261-267 (1983). Review of toxicology and human exposure: Toxicological Profile for Isophorone (PB90-180225, 1989) pp 101.

Gliquidone CAS Registry Number: 33342-05-1 格列喹酮

CAS Name: N-[(Cyclohexylamino)carbonyl]-4-[2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1H)-isoquinolinyl)ethyl]benzenesulfonamide
Additional Names: 1-cyclohexyl-3-[[p-[2-(3,4-dihydro-7-me...
Literature References: Prepn: E. Kutter et al., DE 2000339 (1971 to Thomae); eidem, US 3708486 (1973 to Boehringer, Ing.); eidem, DE 2011126 (1971 to Thomae), C.A. 76, 14359e (1972). Pharmacokinetics and metabolism: Kopitar, Arzneim.-Forsch. 25, 1455 (1975); Kopitar et al., ibid. 1933.

Arprinocid CAS Registry Number: 55779-18-5 阿普西特

CAS Name: 9-[(2-Chloro-6-fluorophenyl)methyl]-9H-purin-6-amine
Additional Names: 9-(2-chloro-6-fluorobenzyl)adenineTrademarks: Arpocox (Merck Co.)
Percent Composition: C 51.90%, H 3.27%, Cl...
Literature References: Prepn: E. P. Lira et al., FR 2128600; eidem, US 3846426 (1972, 1974, both to Int. Minerals and Chem.); G. D. Hartman et al., J. Org. Chem. 43, 960 (1978). Determination in feed: D. W. Fink et al., J. Assoc. Off. Anal. Chem. 61, 1078 (1978); 62, 1 (1979). Evaluation of anticoccidial efficacy: P. Schindler et al., Poult. Sci. 58, 23 (1979); L. R. McDougald, J. K. Johnson, ibid. 72.

Meprednisone CAS Registry Number: 1247-42-3 甲基泼尼松

CAS Name: (16b)-17,21-Dihydroxy-16-methylpregna-1,4-diene-3,11,20-trione
Additional Names: 16b-methylprednisone
Trademarks: Betapred (Schering); Betapar (Parke-Davis); Betalone (Lepetit); De...
Literature References: Prepn: E. P. Oliveto et al., J. Am. Chem. Soc. 80, 4428 (1958); D. Taub et al., ibid. 4435; D. Taub et al., ibid. 82, 4012 (1960); G. G. Nathansohn et al., Experientia 17, 448 (1961); GB 901092 (1962 to Scherico); R. Rausser, E. P. Oliveto, US 3164618 (1965 to Schering).

Bronopol CAS Registry Number: 52-51-7 溴硝丙二醇

CAS Name: 2-Bromo-2-nitro-1,3-propanediol
Additional Names: b-bromo-b-nitrotrimethyleneglycol
Trademarks: Bronosol (Green Cross)
Percent Composition: C 18.02%, H 3.02%, Br 39.95%, N 7.00%...
Literature References: Prepn: E. Schmidt, R. Wilkendorf, Ber. 52, 389 (1919); R. Wessendorf, DE 1804068; idem, DE 1954173; idem, US 3658921; idem, US 3711561 (1970, 1971, 1972, 1973 all to Henkel Cie). Antibacterial, antifungal and toxic properties: Z. Eckstein et al., Bull. Acad. Pol. Sci. Ser. Sci. Chim. 11, 687 (1963); B. Croshaw et al., J. Pharm. Pharmacol. 16 (Suppl), 127T (1964); N. G. Clark et al., GB 1057131; eidem, US 3558788 (1967, 1971 both to Boots); R. J. Stretton, T. W. Mason, J. Appl. Bacteriol. 36, 61 (1973). Biotransformation and distribution in rats: H. S. Buttar, R. H. Downie, Toxicol. Lett. 6, 101 (1980). As a nitrosating agent for diethanolamine: I. Schmeltz, A. Wenger, Food Cosmet. Toxicol. 17, 105 (1979); R. L. Elder, J. Environ. Pathol. Toxicol. 4, 47 (1980). Review of bronopol and other preservatives: B. Croshaw, J. Soc. Cosmet. Chem. 28, 3-16 (1977).

Ramifenazone CAS Registry Number: 3615-24-5 异丙氨基比林

CAS Name: 1,2-Dihydro-1,5-dimethyl-4-[(1-methylethyl)amino]-2-phenyl-3H-pyrazol-3-one
Additional Names: 4-isopropylamino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one; 4-isopropylaminoantipyrine; iso...
Literature References: Prepn: E. Skita, W. Stühmer, DE 930328; DE 932677 (both 1955), C.A. 52, 16372i, 20200h (1958). Acute toxicity: E. Tubaro et al., Arzneim.-Forsch. 20, 1024 (1970). Clinical evaluation of combination with phenylbutazone, q.v., in migraine: W. Sacks, S. Afr. Med. J. 58, 444 (1980).

Bezafibrate CAS Registry Number: 41859-67-0 苯扎贝特

CAS Name: 2-[4-[2-[(4-Chlorobenzoyl)amino]ethyl]phenoxy]-2-methylpropanoic acid
Additional Names: 2-[p-[2-(p-chlorobenzamido)ethyl]phenoxy]-2-methylpropionic acid; a-[4-(4-chlorobenzoylaminoeth...
Literature References: Prepn: E. Witte et al., DE 2149070; eidem, US 3781328 (both 1973 to Boehringer, Mann.). Pharmacology: R. Zimmerman et al., Atherosclerosis 29, 477 (1978). Clinical studies: A. G. Olsson, P. D. Lang, ibid. 31, 421, 429 (1978); P. Wahl et al., Dtsch. Med. Wochenschr. 103, 1233 (1978). Review of pharmacodynamics and therapeutic use: J. P. Monk, P. A. Todd, Drugs 33, 539-576 (1987).

Phenyl Carbonate CAS Registry Number: 102-09-0 碳酸二苯酯

CAS Name: Carbonic acid diphenyl ester
Additional Names: diphenyl carbonate
Percent Composition: C 72.89%, H 4.71%, O 22.41%
Literature References: Prepn: Eckenroth, Ber. 27, 3410 (1894); Bischoff, ibid. 35, 3434 (1902); Gomberg, Snow, J. Am. Chem. Soc. 47, 198 (1925).