其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Quinestrol CAS Registry Number: 152-43-2 炔雌醇环戊醚

CAS Name: (17a)-3-(Cyclopentyloxy)-19-norpregna-1,3,5(10)-trien-20-yn-17-ol
Additional Names: 17a-ethinylestradiol 3-cyclopentyl etherTrademarks: Estrovis (Gecke)
Percent Composition: C 82.3...
Literature References: Prepn: Ercoli, Gardi, Chem. Ind. (London) 1961, 1037; Ercoli, US 3159543; Ercoli et al., US 3231567 (1964, 1966, both to Vismara).

Pyrisuccideanol CAS Registry Number: 33605-94-6 吡舒达诺

CAS Name: Butanedioic acid 2-(dimethylamino)ethyl [5-hydroxy-4-(hydroxymethyl)-6-methyl-3-pyridinyl]methyl ester
Additional Names: pyridoxol 3-[2-(dimethylamino)ethyl succinate]; 2-(dimethylami...
Literature References: Prepn: Esanu, DE 2102831 (1971 to Soc. d'Etudes de Prods. Chim.) corresp to US 3717636 (1973). Activity studies: Hugelin et al., C.R. Seances Soc. Biol. Ses Fil. 166, 1435 (1972).

Bephenium Hydroxynaphthoate CAS Registry Number: 3818-50-6 羟萘酸苄酚宁

CAS Name: N,N-Dimethyl-N-(2-phenoxyethyl)benzenemethanaminium salt with 3-hydroxy-2-naphthalene carboxylic acid (1:1)
Additional Names: bephenium embonate
Trademarks: Lecibis (Columbia)
P...
Literature References: Prepn: F. C. Copp, US 2918401 (1959 to Burroughs Wellcome). Mode of action: G. C. Coles et al., Experientia 30, 1265 (1974). Spectrophotometric determn: C. S. P. Sastry, M. Aruna, Pharmazie 43, 361 (1988). Efficacy against strongylosis in elephants: K. Chandrasekharan et al., Kerala J. Vet. Sci. 13, 15 (1982). Clinical trial in hookworm infections: J. Nahmias et al., Ann. Trop. Med. Parasitol. 83, 625 (1989).

Hexedine CAS Registry Number: 5980-31-4 海克西定

CAS Name: 2,6-Bis(2-ethylhexyl)hexahydro-7a-methyl-1H-imidazo[1,5-c]imidazole
Additional Names: 3,7-bis(2-ethylhexyl)-5-methyl-1,3,7-triazabicyclo[3.3.0]octane
Percent Composition: C 75.15%,...
Literature References: Prepn: F. H. McMillan, DE 1209249; idem, US 3357886 (1966, 1967, both to Warner-Lambert). Compound claimed but not described: Senkus, US 2393826 (1946 to CSC).

Quinapyramine CAS Registry Number: 20493-41-8 甲硫喹嘧胺

CAS Name: 4-Amino-6-[(2-amino-1,6-dimethyl-4(1H)-pyrimidinylidene)amino]-1,2-dimethylquinolinium conjugate monoacid
Additional Names: 4-amino-6-[(2-amino-6-methyl-4-pyrimidinyl)amino]-1-methylq...
Literature References: Prepn: F. H. S. Curd, D. G. Davey, Br. J. Pharmacol. 5, 25 (1950); Curd, US 2585917 (1952 to I.C.I.); Ainley et al., J. Chem. Soc. 1953, 59.

Sulfinpyrazone CAS Registry Number: 57-96-5 苯磺保泰松

CAS Name: 1,2-Diphenyl-4-[2-(phenylsulfinyl)ethyl]-3,5-pyrazolidinedione
Additional Names: 1,2-diphenyl-3,5-dioxo-4-(2-phenylsulfinylethyl)pyrazolidine; 4-(phenylsulfoxyethyl)-1,2-diphenyl-3,5-...
Literature References: Prepn: F. Häfliger, US 2700671 (1955 to Geigy AG); R. Pfister, F. Häfliger, Helv. Chim. Acta 44, 232 (1961). Uricosuric effect: J. J. Burns et al., J. Pharmacol. Exp. Ther. 119, 418 (1957). Clinical trial in prevention of sudden cardiac death: Anturane Reinfarction Trial Research Group, N. Engl. J. Med. 298, 289 (1978); 302, 250 (1980); as antithrombotic: R. D. Sautter et al., J. Am. Med. Assoc. 250, 2649 (1983); D. T. Domoto et al., Thromb. Res. 62, 737 (1991). Review: E. H. Margulies, A. M. White, in Pharmacological and Biochemical Properties of Drug Substances vol. 2, M. E. Goldberg, Ed. (Am. Pharm. Assoc., Washington, DC, 1979) pp 255-278; E. H. Margulies et al., Drugs 20, 179-197 (1980).

Dibenzepin CAS Registry Number: 4498-32-2 二苯西平

CAS Name: 10-[2-(Dimethylamino)ethyl]-5,10-dihydro-5-methyl-11H-dibenzo[b,e][1,4]diazepin-11-one
Additional Names: 5-methyl-10b-dimethylaminoethyl-10,11-dihydro-11-oxodibenzo[b,e][1,4]diazepine...
Literature References: Prepn: F. Hunziker et al., Arzneim.-Forsch. 13, 324 (1963); GB 961106; J. Schmutz, F. Hunziker, US 3312689 and US 3419547 (1964, 1967, 1968 all to Wander). Metabolism: H. Lehner et al., Arzneim.-Forsch. 17, 185 (1967). Comprehensive description: A. Egli, W. R. Michaelis, Anal. Profiles Drug Subs. 9, 181-206 (1980).

Azatadine CAS Registry Number: 3964-81-6 6,11-二氢-11-(1-甲基-4-哌啶亚基)-5H-苯并[5,6]环庚烷并[1,2-b]吡啶

CAS Name: 6,11-Dihydro-11-(1-methyl-4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
Additional Names: 4-aza-5-(N-methyl-4-piperidinylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene<...
Literature References: Prepn: F. J. Villani, BE 647043 (1964 to Scherico); idem, US 3326924 (1967 to Schering); idem et al., J. Med. Chem. 15, 750 (1972). Pharmacology: S. Tozzi et al., Agents Actions 4, 264 (1974). Toxicity studies: H. Tanaka et al., Jitchuken Zenrinsho Kenkyuho 1, 173 (1975), C.A. 84, 25951h (1976). Clinical evaluation in allergic rhinitis: J. D. Wilson et al., N. Z. Med. J. 94, 79 (1981).

o-Cresolphthalein CAS Registry Number: 596-27-0 邻甲酚酞

CAS Name: 3,3-Bis(4-hydroxy-3-methylphenyl)-1(3H)-isobenzofuranone
Additional Names: 3,3'-dimethylphenolphthalein
Percent Composition: C 76.28%, H 5.24%, O 18.48%
Literature References: Prepn: F. J. Welcher, Organic Analytical Reagents vol. 4 (Van Nostrand, New York, 1948) p 482; Hubacher et al., J. Am. Pharm. Assoc. 42, 23 (1953).

Ambenonium Chloride CAS Registry Number: 115-79-7 安贝氯铵

CAS Name: N,N'-[(1,2-Dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis[2-chloro-N,N-diethylbenzenemethanaminium] dichloride
Additional Names: [oxalylbis(iminoethylene)]bis[(o-chlorobenzyl)diet...
Literature References: Prepn: F. K. Kirchner, DE 1024517 (1958 to Sterling Drug), C.A. 54, 18366g (1960). Determn in serum: C. Tharasse-Bloch et al., J. Chromatogr. 421, 407 (1987). Pharmacokinetics in dogs: eidem, Arzneim.-Forsch. 39, 257 (1989).