其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Thiobarbital CAS Registry Number: 77-32-7 5,5-二乙基-2-硫代巴比妥酸

CAS Name: 5,5-Diethyldihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione
Additional Names: 5,5-diethyl-2-thiobarbituric acid
Trademarks: Ibition (IBI)
Percent Composition: C 47.98%, H 6.04%, N 13...
Literature References: Prepn: Fischer, Dilthey, Ann. 335, 350 (1904); Carrington, J. Chem. Soc. 1944, 124. Metabolism in man: Bush et al., J. Pharmacol. Exp. Ther. 134, 110 (1961).

Magenta I CAS Registry Number: 632-99-5 碱性品红

CAS Name: 4-[(4-Aminophenyl)(4-imino-2,5-cyclohexadien-1-ylidene)methyl]-2-methylbenzenamine monohydrochloride
Additional Names: C.I. Basic Violet 14; a4-(p-aminophenyl)-a4-(4-imino-2,5-cyclohe...
Literature References: Prepn: Fischer, Fischer, Ann. 194, 276, 290 (1878); Ber. 13, 2204 (1880); J. T. Scalan, J. Am. Chem. Soc. 57, 887 (1935). Evaluation of carcinogenicity studies: IARC Monographs 4, 57 (1974). See also: Colour Index vol. 4 (3rd ed., 1971) p 4389.

Bismuth Subsalicylate CAS Registry Number: 14882-18-9 碱式水杨酸铋

CAS Name: 2-Hydroxy-4H-1,3,2-benzodioxabismin-4-one
Additional Names: (2-hydroxybenzoato-O1,O2)oxobismuth; oxo(salicylato)bismuth; basic bismuth salicylate; bismuth oxysalicylate
Trademarks:...
Literature References: Prepn: Fischer, Grützner, Arch. Pharm. 231, 680 (1893). Clinical trial in infant diarrhea: D. Figueroa-Quintanilla et al., N. Engl. J. Med. 328, 1653 (1993). Symposium on pharmacology and therapeutic use in gastrointestinal infections: Rev. Infect. Dis. 12, Suppl. 1, S1-S119 (1990). Mechanism of gastroprotection: D. Bagchi et al., Dig. Dis. Sci. 44, 2419 (1999).

Isopropylidene Glycerol CAS Registry Number: 100-79-8 丙酮缩甘油

CAS Name: 2,2-Dimethyl-1,3-dioxolane-4-methanol
Additional Names: 2,2-dimethyl-4-hydroxymethyl-1,3-dioxolane; glycerol dimethylketal; acetone glycerol
Trademarks: Solketal
Percent Composi...
Literature References: Prepn: Fisher, Ber. 28, 1167 (1895); Fisher, Pfähler, Ber. 53, 1607 (1920); Hibbert, Morazain, Can. J. Res. 2, 38 (1930); Smith, Lindberg, Ber. 64, 510 (1931); M. M. Maglio, C. A. Burger, J. Am. Chem. Soc. 68, 529 (1946); M. Renoll, M. S. Newman, Org. Synth. coll. vol. III, 502 (1955); Mikschik, AT 180926 (1955 to Chemomedica Chemikalien), C.A. 49, 15951 (1955); Williams, GB 802022 (1958 to Peter Spence Sons); GB 819835 (1959 to Bayer); Perez et al., ES 499129 (1982 to Calipe), C.A. 97, 55794v (1982). Synthesis of D(+)-form: E. Baer, H. Fischer, J. Biol. Chem. 128, 463 (1939); of L(-)-form: eidem, J. Am. Chem. Soc. 61, 761 (1939). Conversion of D(+)- to L(-)-form: eidem, ibid. 67, 944 (1945).

Ketipic Acid CAS Registry Number: 533-76-6 二酮己二酸

CAS Name: 3,4-Dioxohexanedioic acid
Additional Names: 2,3-diketoadipic acid; oxalodiacetic acid
Percent Composition: C 41.39%, H 3.47%, O 55.14%
Literature References: Prepn: Fittig et al., Ann. 249, 182 (1888); Stachel, Arch. Pharm. 295, 735 (1932); 296, 479 (1963). Structure studies; occurs in the solid form as the g-lactol: Stachel, Ann. 689, 118 (1965).

Butyl Citrate CAS Registry Number: 77-94-1 柠檬酸三丁酯

CAS Name: 2-Hydroxy-1,2,3-propanetricarboxylic acid tributyl ester
Additional Names: citric acid tributyl ester; n-butyl citrate; tributyl citrate
Percent Composition: C 59.98%, H 8.95%, O 3...
Literature References: Prepn: Fodor, Arch. Biochem. 28, 274 (1950). Synthesis from n-butyl alcohol and citric acid: Benedict, Chemistry 47, 27 (1974).

Sodium b -Naphthoquinone-4-sulfonate CAS Registry Number: 521-24-4 1,2-萘醌-4-磺酸钠盐

CAS Name: 3,4-Dihydro-3,4-dioxo-1-naphthalenesulfonic acid sodium salt
Additional Names: sodium 1,2-naphthoquinone-4-sulfonate; 1,2-naphthoquinone-4-sulfonic acid sodium salt; b-naphthoquinone-...
Literature References: Prepn: Folin, J. Biol. Chem. 51, 377 (1922).

Novembichin CAS Registry Number: 1936-40-9

CAS Name: 2-Chloro-N,N-bis(2-chloroethyl)propanamine hydrochloride
Additional Names: 2-chloropropyldi(2-chloroethyl)amine hydrochloride
Trademarks: Novoembichin; Embichin 7; Embikhin 7
Pe...
Literature References: Prepn: Ford-Moore et al., J. Chem. Soc. 1946, 819; E. Wilson, M. Tishler, J. Am. Chem. Soc. 73, 3635 (1951).

Lachesine CAS Registry Number: 1164-38-1 氯苯醇酸铵乙酯盐酸盐

CAS Name: N-Ethyl-2-[(hydroxydiphenylacetyl)oxy]-N,N-dimethylethanaminium chloride
Additional Names: ethyl(2-hydroxyethyl)dimethylammonium chloride benzilatePercent Composition: C 66.01%, H 7.2...
Literature References: Prepn: Ford-Moore, Ing, J. Chem. Soc. 1947, 55. Pharmacology: H. R. Ing et al., J. Pharmacol. Exp. Ther. 85, 85 (1945). Muscarinic receptor agonist: F. Roberts, R. P. Stephenson, Br. J. Pharmacol. 57, 395 (1976); D. A. Brown, S. Fatherazi, ibid. 59, 500P (1977); N. J. M. Birdsall et al., Mol. Pharmacol. 14, 723 (1978).

Sulfamethylthiazole CAS Registry Number: 515-59-3 4-氨基-N-(4-甲基噻唑-2-基)苯磺酰胺

CAS Name: 4-Amino-N-(4-methyl-2-thiazole)benzenesulfonamide
Additional Names: 4-methyl-2-sulfanilamidothiazole; N1-(4-methyl-2-thiazolyl)sulfanilamide; 2-(p-aminobenzenesulfonamido)-4-methylthi...
Literature References: Prepn: Fosbinder, Walter, J. Am. Chem. Soc. 61, 2032 (1939). Alternate routes of synthesis: E. H. Northey, The Sulfonamides and Allied Compounds (Reinhold, New York, 1948) p 89.