其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Plasmocid CAS Registry Number: 551-01-9 6-甲氧基-8-(3-二乙基氨基丙基氨基)喹啉

CAS Name: N,N-Diethyl-N'-(6-methoxy-8-quinolinyl)-1,3-propanediamine
Additional Names: 8-(3-diethylaminopropylamino)-6-methoxyquinoline; 6-methoxy-8-(3-diethylaminopropylamino)quinolineTrademar...
Literature References: Prepn: Fourneau et al., Ann. Inst. Pasteur 44, 503 (1930); 46, 514 (1931); 50, 731 (1933); Magidson, Strukov, Arch. Pharm. 271, 359 (1933); Strukov, SU 39105 (1934), C.A. 30, 3445 (1936); Magidson et al., J. Appl. Chem. USSR 9, 304 (1936); Giral, Ciencia (Mexico City) 6, 253 (1945), C.A. 40, 3563 (1946); Yanko et al., J. Am. Chem. Soc. 67, 664 (1945).

Succisulfone CAS Registry Number: 5934-14-5 4-((4-((4-氨基苯基)磺酰基)苯基)氨基)-4-氧丁酸

CAS Name: 4-[[4-[(4-Aminophenyl)sulfonyl]phenyl]amino]-4-oxobutanoic acid
Additional Names: 4'-sulfanilylsuccinanilic acid; 4-amino-4'-(b-carboxypropionylamino)phenylsulfonylbenzene; 4-amino-4'...
Literature References: Prepn: Fourneau, Tréfouel, FR 866619 (1941 to Rhône-Poulenc); Kharasch, Reinmuth, US 2268754 (1942 to Lilly); Bauer, J. Am. Chem. Soc. 70, 2254 (1948); Rohls, Behnish, DE 895600 (1953 to Bayer); Liberman, FR 1020713 (1953 to Chimie et Atomistique).

Thioguanosine CAS Registry Number: 85-31-4 6-硫基鸟嘌呤

Additional Names: 2-Amino-6-mercapto-9-b-D-ribofuranosylpurine
Percent Composition: C 40.13%, H 4.38%, N 23.40%, O 21.38%, S 10.71%
Literature References: Prepn: Fox et al., J. Am. Chem. Soc. 80, 1669 (1948).

Hexylene Glycol CAS Registry Number: 107-41-5 异己二醇

CAS Name: 2-Methyl-2,4-pentanediol
Additional Names: a,a,a'-trimethyltrimethyleneglycol; pinakon
Percent Composition: C 60.98%, H 11.94%, O 27.08%
Literature References: Prepn: Franke, Monatsh. Chem. 22, 1067 (1901); Leopold, DE 486767 (1925 to I. G. Farben), Frdl. 16, 679; Adkins, Cramer, J. Am. Chem. Soc. 52, 4349 (1930); Arundale, Mikeska, US 2367324 (1945 to Standard Oil). Toxicity study: Smyth, Carpenter, J. Ind. Hyg. Toxicol. 30, 63 (1948).

n-Butyl Iodide CAS Registry Number: 542-69-8 碘代正丁烷

CAS Name: 1-Iodobutane
Percent Composition: C 26.11%, H 4.93%, I 68.96%
Literature References: Prepn: Franzen, Ber. 87, 1148 (1954); Landauer, Rydon, J. Chem. Soc. 1954, 2281; Stone, Shechter, Org. Synth. coll. vol. IV, 321 (1963). Manuf: Huber, Schenck, US 2899471 and US 3053910 (1959 and 1962, both to GAF).

Cortivazol CAS Registry Number: 1110-40-3 可的伐唑

CAS Name: (11b,16a)-21-(Acetyloxy)-11,17-dihydroxy-6,16-dimethyl-2'-phenyl-2'H-pregna-2,4,6-trieno[3,2-c]pyrazol-20-one
Additional Names: 1,2,3,3a,3b,7,10,10a,10b,11,12,12a-dodecahydro-1,11-dih...
Literature References: Prepn: Fried et al., J. Am. Chem. Soc. 85, 236 (1963); Tishler et al., US 3067194 and US 3300483 (1962, l967 to Merck Co.).

Stibocaptate CAS Registry Number: 27279-76-1

CAS Name: 2,2'-[(1,2-Dicarboxy-1,2-ethanediyl)bis(thio)]bis-1,3,2-dithiastibolane-4,5-dicarboxylic acid hexasodium salt
Additional Names: 2,3-dimercaptosuccinic acid cyclic ester with antimonic...
Literature References: Prepn: Friedheim, US 2880222 (1959). Prepn and antischistosomal activity: J.-K. Hsu, M.-K. Ch'en, K'o Hsueh T'ung Pao 1966, 978, C.A. 65, 17580e (1966). Toxicity data: Ercoli, Proc. Soc. Exp. Biol. Med. 129, 284 (1968).

Clobenztropine CAS Registry Number: 5627-46-3 氯苯托品

CAS Name: 3-[(4-Chlorophenyl)phenylmethoxy]-8-methyl-8-azabicyclo[3.2.1]octane
Additional Names: 3-[(p-chloro-a-phenylbenzyl)oxy]tropane; tropine 4-chlorobenzhydryl ether
Trademarks: Teprin ...
Literature References: Prepn: Fromer, US 2799680 (1957); Nield, Bosch, US 2782200 (1957 to Schenley Labs.).

Acedapsone CAS Registry Number: 77-46-3 N-[4-(4-乙酰氨基苯基)磺酰基苯基]乙酰胺

CAS Name: N,N'-(Sulfonyldi-4,1-phenylene)bisacetamide
Additional Names: 4',4'''-sulfonylbis[acetanilide]; bis(4-acetamidophenyl)sulfone; 4,4'-diacetyldiaminodiphenyl sulfone; 4,4'-diacetylamino...
Literature References: Prepn: Fromm, Wittmann, Ber. 41, 2270 (1908); Raiziss et al., J. Am. Chem. Soc. 61, 2763 (1939); Elslager et al., J. Med. Chem. 12, 357 (1969). Properties: Elslager, Worth, Nature 206, 630 (1965). Clinical trial in leprosy: C. R. Boughton et al., Med. J. Aust. 1, 1258 (1971); P. N. Neelan et al., Indian J. Lepr. 58, 251 (1986).

Tetraglycine Hydroperiodide CAS Registry Number: 7097-60-1

Trademarks: Globaline (Arapahoe)
Percent Composition: C 12.89%, H 2.84%, I 59.58%, N 7.52%, O 17.17%
Literature References: Prepn: Frost, Eddy, J. Am. Chem. Soc. 74, 1346 (1952); Morris et al., Ind. Eng. Chem. 45, 1013 (1953).