其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Nifurpirinol CAS Registry Number: 13411-16-0 硝呋吡醇

CAS Name: 6-[2-(5-Nitro-2-furanyl)ethenyl]-2-pyridinemethanol
Additional Names: 6-[2-(5-nitro-2-furyl)vinyl]-2-pyridinemethanol; 6-(hydroxymethyl)-2-[2-(5-nitro-2-furyl)vinyl]pyridine; furpirin...
Literature References: Prepn: Fujita et al., J. Pharm. Soc. Jpn. 86, 1014 (1966); GB 1053730 (1967 to Dainippon), C.A. 66, 115605f (1967); Murakami, Iwanami, JP 70 14072 (1970 to Yamanouchi), C.A. 73, 45364v (1970). Antibacterial activity: Shimizu, Takase, Prog. Antimicrob. Anticancer Chemother., Proc. 6th Int. Congr. Chemother. 2, 388 (1970); D. F. Amend, A. J. Ross, Prog. Fish Cult. 32, 19 (1970); A. J. Ross, ibid. 34, 18 (1972); Y. Takase et al., Chem. Pharm. Bull. 21, 144 (1973).

Etafenone CAS Registry Number: 90-54-0 依他苯酮

CAS Name: 1-[2-[2-(Diethylamino)ethoxy]phenyl]-3-phenyl-1-propanone
Additional Names: 2'-[2-(diethylamino)ethoxy]-3-phenylpropiophenone; o-diethylaminoethoxy-b-phenylpropiophenone; 2'-(b-diethy...
Literature References: Prepn: G. DiPaco, S. C. Tauro, Ann. Chim. (Rome) 48, 1215 (1958); eidem, DE 1265758 (1968 to Guidotti), C.A. 69, 58950a (1968). Toxicity data: H.-J. Hapke, W. Sterner, Arzneim.-Forsch. 19, 1664 (1969). Series of articles on pharmacology, toxicology, metabolism: ibid. 1664-1681.

Tris-BP CAS Registry Number: 126-72-7 磷酸三(2,3-二溴丙基)酯

CAS Name: 2,3-Dibromo-1-propanol phosphate(3:1)
Additional Names: phosphoric acid tris(2,3-dibromopropyl) ester; tris(2,3-dibromopropyl) phosphate
Trademarks: Apex 462-5; Flammex AP; Flammex...
Literature References: Prepn: G. E. Walter, I. Hornstein, US 2574515 (1951 to Glenn. L. Martin Co.); D. E. Overbeek, R. C. Nametz, US 3046297 (1962 to Michigan Chem. Co.); R. W. Rimmer, US 3223755 (1965 to duPont). Use in flameproofing: W. D. Paist, N. Van Gorder, US 2662834 (1953 to Celanese). Mutagenicity studies: M. J. Prival et al., Science 195, 76 (1977); A. Nakamura et al., Mutat. Res. 66, 373 (1979). Carcinogenicity studies: B. L. Van Duuren et al., Cancer Res. 38, 3236 (1978); G. Reznik et al., J. Natl. Cancer Inst. 63, 205 (1979). Review of toxicology: F. A. Daniher, Proc. Symp. Text. Flammability 4, 126-143 (1976). Review: A. Blum, B. N. Ames, Science 195, 17 (1977).

Prenylamine CAS Registry Number: 390-64-7 普尼拉明

CAS Name: N-(1-Methyl-2-phenylethyl)-g-phenylbenzenepropanamine
Additional Names: N-(3,3-diphenylpropyl)-a-methylphenethylamine; N-(3'-phenyl-2'-propyl)-1,1-diphenyl-3-propylamine; 1-phenyl-2-[...
Literature References: Prepn: G. Ehrhart et al., DE 1100031 C.A. 56, 3413h (1962) and DE 1111642 corresp to US 3152173 (1961, 1961, 1964 all to Hoechst); G. Erhart, Arch. Pharm. 295, 196 (1962). Series of articles on pharmacology and chemistry: Arzneim.-Forsch. 10, 569-588 (1960). Metabolism: M. Volz, ibid. 21, 1320 (1971). Review: J. E. Murphy, J. Int. Med. Res. 1, 204-209 (1973).

Doxefazepam CAS Registry Number: 40762-15-0 度氟西泮

CAS Name: 7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-1-(2-hydroxyethyl)-2H-1,4-benzodiazepin-2-one
Additional Names: N-1-hydroxyethyl-3-hydroxyflurazepamTrademarks: Doxans (Schiapparelli...
Literature References: Prepn: G. F. Tamagnone et al., Arzneim.-Forsch. 25, 720 (1975); eidem, J. Pharm. Pharmacol. 26, 566 (1974); F. De Marchi, G. F. Tamagnone, DE 2338058 (1974 to Schiapparelli), C.A. 80, 121016v (1974). Comparison with flurazepam, q.v., and pharmacology, toxicity studies: M. Babbini et al., Arzneim.-Forsch. 25, 1294 (1975). Structure-activity studies: eidem, Pharmacol. Res. Commun. 7, 337 (1975). GC determn in blood and tissue: F. Marcucci et al., J. Chromatogr. 198, 180 (1980); in plasma, urine: S. Mardente et al., Ther. Drug Monit. 3, 351 (1981). Quantitative EEG, behavioral effects: W. G. Sanita et al., ibid. 341. Effect on sleep: G. Rodriguez et al., Neuropsychobiology 11, 133 (1984).

Mequitazine CAS Registry Number: 29216-28-2 美喹他嗪

CAS Name: 10-(1-Azabicyclo[2.2.2]oct-3-ylmethyl)-10H-phenothiazine
Additional Names: 10-(3-quinuclidinylmethyl)phenothiazineTrademarks: Butix (Fabre); Metaplexan (Rhe-Poulenc); Mircol (Rhe-Poul...
Literature References: Prepn: G. Gueremy et al., DE 2009555 corresp to US 3987042 (1970, 1976 to Sogeras). Absorption, distribution, and excretion: A. Uzan et al., Xenobiotica 6, 633 (1976). Biotransformation: eidem, ibid. 649. Pharmacologic study: eidem, J. Pharm. Pharmacol. 31, 701 (1979). Clinical studies: J. Blamoutier, Curr. Med. Res. Opin. 5, 366 (1978); P. Laugier, M. Orusco, ibid. 371.

Rimiterol CAS Registry Number: 32953-89-2 利米特罗

CAS Name: 4-(Hydroxy-2-piperidinylmethyl)-1,2-benzenediol
Additional Names: erythro-a-(3,4-dihydroxyphenyl)-2-piperidinemethanol; erythro-3,4-dihydroxyphenyl-2-piperidinylcarbinol
Percent Co...
Literature References: Prepn: G. H. Sankey, K. D. E. Whiting, DE 2024049; idem, US 3910934 (1970, 1975 to 3M); C. Kaiser, S. T. Ross, DE 2047937; idem, US 3705169 (1971, 1972 to SK F); G. H. Sankey, K. D. E. Whiting, J. Heterocycl. Chem. 9, 1049 (1972). Pharmacology: Carney et al., Arch. Int. Pharmacodyn. Ther. 194, 334 (1971); Griffin, Turner, J. Clin. Pharmacol. 11, 280 (1971); Bowman, Rodger, Br. J. Pharmacol. 45, 574 (1972).

Suloctidil CAS Registry Number: 54063-56-8 索罗克替

CAS Name: 4-[(1-Methylethyl)thio]-a-[1-(octylamino)ethyl]benzenemethanol
Additional Names: erythro-p-(isopropylthio)-a-[1-(octylamino)ethyl]benzyl alcohol; 1-(4-isopropylthiophenyl)-2-octylamin...
Literature References: Prepn: G. Lambelin et al., DE 2334404 (1974 to Continental Pharma), C.A. 82, 97820w (1975). Pharmacology: R. Roncucci et al., Naturwissenschaften 62, 141 (1975); J. Roba et al., Eur. J. Pharmacol. 37, 265 (1976); eidem, Arch. Int. Pharmacodyn. 221, 54 (1976); T. Godfraind, ibid. 342.

Clazuril CAS Registry Number: 101831-36-1 克拉珠利

CAS Name: 2-Chloro-a-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)benzeneacetonitrile
Additional Names: (±)-[2-chloro-4-(4,5-dihydro-3,5-dioxo-as-triazin-2(3H)-yl)pheny...
Literature References: Prepn: G. M. Boeckx et al., EP 170316; eidem, US 4631278 (both 1986 to Janssen). Anticoccidial effect in pigeons: W. Coussement et al., Res. Vet. Sci. 45, 117 (1988).

Diphenhydramine CAS Registry Number: 58-73-1 苯海拉明

CAS Name: 2-Diphenylmethoxy-N,N-dimethylethanamine
Additional Names: 2-(benzhydryloxy)-N,N-dimethylethylamine; b-dimethylaminoethyl benzhydryl ether; O-benzhydryldimethylaminoethanol; b-dimethy...
Literature References: Prepn: G. Rieveschl, Jr., US 2421714 (1947 to Parke, Davis); see also H. Martin et al., US 2397799 (1946 to Geigy). Toxicology study: O. M. Gruhzit, R. A. Fisken, J. Pharmacol. Exp. Ther. 89, 227 (1947). Comprehensive description of the hydrochloride: I. J. Holcomb, S. A. Fusari, Anal. Profiles Drug Subs. 3, 173-232 (1974). Clinical pharmacokinetics: J. M. Scavone et al., J. Clin. Pharmacol. 38, 603 (1998). Clinical trial in insomnia: K. Rickels et al., ibid. 23, 235 (1983).