其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Cyclorphan CAS Registry Number: 4163-15-9 17-(环丙基甲基)吗喃-3-醇

CAS Name: 17-(Cyclopropylmethyl)morphinan-3-ol
Additional Names: (-)-3-hydroxy-N-cyclopropylmethylmorphinan
Percent Composition: C 80.76%, H 9.15%, N 4.71%, O 5.38%
Literature References: Prepn: Gates, Montzka, J. Med. Chem. 7, 127 (1964); Gates, US 3285922 (1966 to Res. Corp.). Pharmacology: Harris et al., Arch. Int. Pharmacodyn. Ther. 165, 112 (1967).

Cetrimonium Stearate CAS Registry Number: 124-23-2 六甲基三甲基铵硬脂酸盐

CAS Name: N,N,N-Trimethyl-1-hexadecanaminium octadecanoate
Additional Names: hexadecyltrimethylammonium stearate; cetyltrimethylammonium stearate; trimethylhexadecylammonium stearate
Tradema...
Literature References: Prepn: Gautier et al., Bull. Soc. Chim. Fr. 1955, 634.

Fluindione CAS Registry Number: 957-56-2 氟茚二酮

CAS Name: 2-(4-Fluorophenyl)-1H-indene-1,3(2H)-dione
Additional Names: 2-(p-fluorophenyl)-1,3-indandioneTrademarks: Previscan (Procter Gamble)
Percent Composition: C 75.00%, H 3.78%, F 7.91...
Literature References: Prepn: Geiger et al., DE 1130439 (1962 to USV), C.A. 57, 12403a (1962); Molho, Boschetti, FR 1369396 and FR M 6913 (1964, 1969 to LIPHA), C.A. 62, 3988g (1965); 74, 141378u (1971). Alternate syntheses: Shapiro et al., J. Org. Chem. 26, 3580 (1961); Hrnciar, Kovalcik, Chem. Zvesti 16, 200 (1962). Activity and toxicity data: Fontaine et al., Med. Pharmacol. Exp. 17, 497 (1967).

Sulfabenz CAS Registry Number: 127-77-5 4-氨基-N-苯基苯磺酰胺

CAS Name: 4-Amino-N-phenylbenzenesulfonamide
Additional Names: sulfanilanilide; p-aminobenzenesulfonanilide; p-aminophenylsulfonamidobenzene; N1-phenylsulfanilamide
Percent Composition: C 58...
Literature References: Prepn: Gelmo, J. Prakt. Chem. 77, 369 (1908); Mastryukova et al., Tetrahedron 19, 357 (1963).

Furaltadone CAS Registry Number: 139-91-3 呋喃他酮

CAS Name: 5-(4-Morpholinylmethyl)-3-[[(5-nitro-2-furanyl)methylene]amino]-2-oxazolidinone
Additional Names: 5-morpholinomethyl-3-(5-nitrofurfurylideneamino)-2-oxazolidinone; 3-(5-nitro-2-furfur...
Literature References: Prepn: Gever, US 2802002 (1957 to Norwich). LC-MS/MS determn of residues in meat: P. Mottier et al., J. Chromatogr. A 1067, 85 (2005).

Nifuradene CAS Registry Number: 555-84-0 硝呋拉定

CAS Name: 1-[[(5-Nitro-2-furanyl)methylene]amino]-2-imidazolidinone
Additional Names: oxafuradene (rescinded)Trademarks: Renafur (Eaton)
Percent Composition: C 42.86%, H 3.60%, N 24.99%, O 2...
Literature References: Prepn: Gever, Michels, US 2746960 (1956 to Norwich Pharm.); eidem, J. Am. Chem. Soc. 78, 5349 (1956); Michels, US 2776979 (1957 to Norwich Pharm.). Toxicity data: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).

Aluminum Stearate CAS Registry Number: 637-12-7 硬脂酸铝

CAS Name: Octadecanoic acid aluminum salt
Additional Names: stearic acid aluminum salt; aluminum tristearate
Percent Composition: C 73.92%, H 12.06%, Al 3.08%, O 10.94%
Literature References: Prepn: Gilmour et al., J. Chem. Soc. 1956, 1972.

Choline Dehydrocholate CAS Registry Number: 4201-78-9 4-[(E)-(3-氨基苯基)二氮烯基]苯-1,3-二胺

Additional Names: Dehydrocholic acid salt of choline
Trademarks: Biscolan
Percent Composition: C 68.74%, H 9.55%, N 2.76%, O 18.95%
Literature References: Prepn: Giovambattista, Rev. Asoc. Bioquim. Argent. 19, 180 (1954), C.A. 49, 13275 (1955).

Sulfoniazide CAS Registry Number: 3691-81-4 3-[(E)-(异烟酰亚肼基)甲基]苯磺酸

CAS Name: 4-Pyridinecarboxylic acid [(3-sulfophenyl)methylene]hydrazide
Additional Names: isonicotinic acid m-sulfobenzylidene hydrazide; isonicotinyl hydrazonotoluene-m-sulfonic acidPercent Co...
Literature References: Prepn: Girard, US 2727041 (1955 to Lab. Français Chimiother.); Sugimoto, JP 57 1117 (1957 to Tanake), C.A. 52, 4696e (1958).

Sulfachrysoidine CAS Registry Number: 485-41-6 磺胺柯定

CAS Name: 3,5-Diamino-2-[[4-(aminosulfonyl)phenyl]azo]benzoic acid
Additional Names: 3,5-diamino-2-[p-(sulfamoylphenyl)azo]benzoic acid; carboxysulfamidochrysoidine; Azo Compd No. 4
Trademar...
Literature References: Prepn: Gley, Girard, C.R. Seances Soc. Biol. Ses Fil. 125, 1027 (1937).