其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Piprozolin CAS Registry Number: 17243-64-0 哌普唑林

CAS Name: [3-Ethyl-4-oxo-5-(1-piperidinyl)-2-thiazolidinylidene]acetic acid ethyl ester
Additional Names: 3-ethyl-4-oxo-5-piperidino-D2,a-thiazolidineacetic acid ethyl esterTrademarks: Coleflux...
Literature References: Prepn: G. Satzinger, Ann. 665, 150 (1963); G. Satzinger et al., DE 2414345 (1975 to Goedecke), corresp to US 3971794 (1976 to Warner-Lambert). Metabolism and pharmacokinetics: K. O. Vollmer, F. W. Koss, Arch. Int. Pharmacodyn. Ther. 198, 312 (1972). Mechanism of action: F. W. Koss et al., ibid. 333. Series of articles on synthesis, pharmacology, toxicology and clinical studies: Arzneim.-Forsch. 27, 463-526 (1977). Toxicity data: M. Herrmann et al., ibid. 467.

p-Nitrobiphenyl CAS Registry Number: 92-93-3 4-硝基联苯

CAS Name: 4-Nitro-1,1'-biphenyl
Additional Names: 4-nitrobiphenyl; p-nitrodiphenyl; PNB
Percent Composition: C 72.35%, H 4.55%, N 7.03%, O 16.06%
Literature References: Prepn: G. Schultz, Ann. 174, 210 (1874); O. Kühling, Ber. 28, 42 (1895); E. Bamberger, ibid. 404; R. L. Jenkins et al., Ind. Eng. Chem. 22 (1), 31 (1930); K. Dimroth et al., Ber. 101, 2215 (1968). Crystal structure: M. Prasad et al., J. Indian Chem. Soc. 13, 519 (1936), C.A. 31, 12715 (1937). Review of carcinogenic risk: IARC Monographs vol. 4, 113-117 (1974).

Fluoresone CAS Registry Number: 2924-67-6 氟苯乙砜

CAS Name: 1-(Ethylsulfonyl)-4-fluorobenzene
Additional Names: ethyl p-fluorophenyl sulfone; p-fluorophenyl ethyl sulfone
Trademarks: Bripadon; Caducid (Wassermann)
Percent Composition: C ...
Literature References: Prepn: G. Thuillier et al., Compt. Rend. 248, 2492 (1959); P. Rumpf, G. Thuillier, FR M399; eidem, US 3084101 (1962, 1963 both to Centre Nat. Recher. Scient.); A. A. Mignot, P. Rumpf, Bull. Soc. Chim. Fr. 1968, 435. Pharmacology: J. Thuillier et al., Proc. 3rd Meet Coll. Int. Neuro-Psychopharmacol. 1962, 317-326 (Publ. 1964). Clinical evaluation: H. Akimoto, S. Taen, ibid. 326. Gas chromatography: E. Marozzi et al., Farmaco Ed. Prat. 31, 180 (1976).

Nalidixic Acid CAS Registry Number: 389-08-2 萘啶酮酸

CAS Name: 1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid
Additional Names: 3-carboxy-1-ethyl-7-methyl-1,8-naphthyridin-4-one; 1-ethyl-7-methyl-1,8-naphthyridin-4-one-3-c...
Literature References: Prepn: G. Y. Lesher et al., J. Med. Pharm. Chem. 5, 1063 (1962); G. Y. Lesher, M. D. Gruett, BE 612258; eidem, US 3590036 (1962, 1971 both to Sterling Drug). Mechanism of action studies: G. J. Bourguignon et al., Antimicrob. Agents Chemother. 4, 479 (1973); W. A. Goss, T. M. Cook, Antibiotics vol. 3, J. W. Corcoran, F. E. Hahn, Eds. (Springer-Verlag, New York, 1975) pp 174-196; A. M. Pedrini, ibid. vol. 5 (pt. 1), F. E. Hahn, Ed. (1979) pp 154-175; H. T. Wright et al., Science 213, 455 (1981). Comprehensive description: P. E. Grubb, Anal. Profiles Drug Subs. 8, 371-397 (1979).

Acetylleucine Monoethanolamine CAS Registry Number: 149-90-6

CAS Name: N-Acetyl-DL-leucine compd with 2-aminoethanol (1:1)
Additional Names: monoethanolamine DL-acetylleucinate; DL-acetylleucine monoethanolamine salt; monoethanolamine salt of a-acetamido...
Literature References: Prepn: Gailliot et al., US 2941924 (1960 to Rhône-Poulenc).

Clofibric Acid CAS Registry Number: 882-09-7 2-(4-氯苯氧基)异丁酸

CAS Name: 2-(4-Chlorophenoxy)-2-methylpropanoic acid
Additional Names: 2-(p-chlorophenoxy)-2-methylpropionic acid; a-(p-chlorophenoxy)isobutyric acid; chlorophibrinic acid
Trademarks: Arteri...
Literature References: Prepn: Galimberti, Defranceschi, Gazz. Chim. Ital. 77, 431 (1947); Gilman, Wilder, J. Am. Chem. Soc. 77, 6644 (1955); Jones et al., GB 860303 (1961 to I.C.I.). Prepn and resolution of isomers: Witiak et al., J. Med. Chem. 11, 1086 (1968). Activity thought to be due to its displacement of thyroxin and its inhibition of cholesterol biosynthesis. See Chang et al., Biochem. Pharmacol. 16, 2053 (1967); Walsh et al., Arch. Biochem. Biophys. 130, 7 (1969); Witiak et al., J. Med. Chem. 14, 754 (1971). Metabolism: Almirante et al., Boll. Chim. Farm. 108, 292 (1969).

Hexamethylolmelamine CAS Registry Number: 531-18-0 六羟甲基三聚氰胺

CAS Name: (1,3,5-Triazine-2,4,6-triyltrinitrilo)hexakismethanol
Additional Names: (s-triazine-2,4,6-triyltrinitrilo)hexamethanol; hexakis(hydroxymethyl)melamine
Trademarks: Resloom M 75 (Mon...
Literature References: Prepn: Gams et al., Helv. Chim. Acta 24, 302E (1941); Widmer, Fisch, US 2387547 (1945 to Ciba).

Flumetramide CAS Registry Number: 7125-73-7 氟美吗酮

CAS Name: 6-[4-(Trifluoromethyl)phenyl]-3-morpholinone
Additional Names: 6-(a,a,a-trifluoro-p-tolyl)-3-morpholinonePercent Composition: C 53.88%, H 4.11%, F 23.24%, N 5.71%, O 13.05%
Literature References: Prepn: Gannon, Poos, US 3308121 (1967 to McNeil).

Lead Thiocyanate CAS Registry Number: 592-87-0 硫氰化铅

Additional Names: Lead sulfocyanate
Percent Composition: C 7.43%, N 8.66%, Pb 64.08%, S 19.83%
Literature References: Prepn: Gardner, Weinberger, Inorg. Synth. 1, 85 (1939).

n-Amyl Butyrate CAS Registry Number: 540-18-1 丁酸戊酯

CAS Name: Butanoic acid pentyl ester
Percent Composition: C 68.31%, H 11.47%, O 20.22%
Literature References: Prepn: Gartenmeister, Ann. 233, 269 (1886). Toxicity study: P. M. Jenner et al., Food Cosmet. Toxicol. 2, 327 (1964).