网站主页>>>项目整合精选>>>项目整合精选>>>Clofibric Acid CAS Registry Number: 882-09-7 2-(4-氯苯氧基)异丁酸

Clofibric Acid CAS Registry Number: 882-09-7 2-(4-氯苯氧基)异丁酸

CAS Name: 2-(4-Chlorophenoxy)-2-methylpropanoic acid
Additional Names: 2-(p-chlorophenoxy)-2-methylpropionic acid; a-(p-chlorophenoxy)isobutyric acid; chlorophibrinic acid
Trademarks: Arteriohom (Weisskopf); Regulipid (Heilit)
Percent Composition: C 55.95%, H 5.17%, Cl 16.52%, O 22.36%

📌 参考资料/链接：
Literature References: Prepn: Galimberti, Defranceschi, Gazz. Chim. Ital. 77, 431 (1947); Gilman, Wilder, J. Am. Chem. Soc. 77, 6644 (1955); Jones et al., GB 860303 (1961 to I.C.I.). Prepn and resolution of isomers: Witiak et al., J. Med. Chem. 11, 1086 (1968). Activity thought to be due to its displacement of thyroxin and its inhibition of cholesterol biosynthesis. See Chang et al., Biochem. Pharmacol. 16, 2053 (1967); Walsh et al., Arch. Biochem. Biophys. 130, 7 (1969); Witiak et al., J. Med. Chem. 14, 754 (1971). Metabolism: Almirante et al., Boll. Chim. Farm. 108, 292 (1969).

📄 详细内容

Properties: Crystals from water or methanol, mp 118-119°.
Melting point: mp 118-119°
Derivative Type: Basic aluminum salt
CAS Registry Number: 24818-79-9
Trademarks: Alufibrate; Atherolip; Atherolipin (Schwarz)
Percent Composition: C 50.97%, H 4.49%, Al 5.73%, Cl 15.05%, O 23.77%
Derivative Type: Magnesium salt
CAS Registry Number: 14613-30-0
Additional Names: Magnesium clofibrateTrademarks: Clomag
Percent Composition: C 53.19%, H 4.46%, Cl 15.70%, Mg 5.38%, O 21.26%
Properties: White powder, mp 326-328°. Soly in g/100 mg: water 4.5; abs ethanol 0.7; chloroform 0.02.
Melting point: mp 326-328°
Derivative Type: Pyridoxine salt
CAS Registry Number: 29952-87-2
Additional Names: Pyridoxine p-chlorophenoxyisobutyrate
Trademarks: Claresan
Percent Composition: C 56.33%, H 5.78%, Cl 9.24%, O 25.01%, N 3.65%
Literature References: Prepn: Sarbach et al.,
DE
1915497 (1970 to Inst. Rech. Sci.), C.A.
74, 13011g (1971).
Derivative Type: Ethyl ester see Clofibrate
Derivative Type: Etofylline ester see Theofibrate
Therap-Cat: Antilipemic.
Keywords: Antilipemic; Fibrates.
产品链接: 882-09-7››

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