其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Hexachlorobutadiene CAS Registry Number: 87-68-3 六氯-1,3-丁二烯

CAS Name: 1,1,2,3,4,4-Hexachloro-1,3-butadiene
Additional Names: perchlorobutadiene
Percent Composition: C 18.42%, Cl 81.58%
Literature References: Prepn: F. Krafft, Ber. 10, 801 (1877); E. T. McBee, R. E. Hatton, Ind. Eng. Chem. 41, 809 (1949); J. Jelinek, M. Hudlicky, Collect. Czech. Chem. Commun. 22, 651 (1957). GC determn in blood: P. E. Kastl, E. A. Hermann, J. Chromatogr. 280, 390 (1983). Toxicity study: D. Gradiski et al., Eur. J. Toxicol. Environ. Hyg. 8, 180 (1975). Review of toxicology and human exposure: Toxicological Profile for Hexachlorobutadiene (PB95-100160, 1994) 135 pp. Review: G. Choudhary, Environ. Carcinog. Ecotoxicol. Rev. C13, 179-203 (1995).

Trifluoroacetic Acid CAS Registry Number: 76-05-1 三氟乙酸(TFA)

Additional Names: Perfluoroacetic acid
Percent Composition: C 21.07%, H 0.88%, F 49.99%, O 28.06%
Literature References: Prepn: F. Swarts, Bull. Sci. Acad. R. Belg. 8, 343 (1922); by oxidation of fluorine olefins: A. L. Henne, US 2371757 (1945 to du Pont); A. L. Henne et al., J. Am. Chem. Soc. 67, 918 (1945). Improved prepn: A. L. Henne, P. Trott, ibid. 69, 1820 (1947). Photochemical prepn: R. N. Hazeldine, F. Nyman, J. Chem. Soc. 1959, 387; eidem, ibid. 420. Toxicity and metabolism: M. M. Airaksinen, T. Tammisto, Ann. Med. Exp. Biol. Fenn. 46, 242 (1968). Review: J. B. Milne in Chem. Non-Aqueous Solvents vol. 5B, J. J. Lagowski, Ed. (Academic Press, New York, 1978) pp 1-52.

Difenpiramide CAS Registry Number: 51484-40-3 2-([1,1'-联苯]-4-基)-N-(吡啶-2-基)乙酰胺

CAS Name: N-2-Pyridinyl-[1,1'-biphenyl]-4-acetamide
Additional Names: diphenpyramideTrademarks: Difenax (Zambeletti)
Percent Composition: C 79.14%, H 5.59%, N 9.72%, O 5.55%
Literature References: Prepn: F. Tenconi, R. M. Tagliabue, DE 2325309 (1973 to Zambeletti); L. Molteni et al., US 3868380 (1975). Pharmacological properties: S. Caliari et al., Arzneim.-Forsch. 27, 2086 (1977). Physicochemical profile: A. Trebbi, G. Filippi, Boll. Chim. Farm. 118, 729 (1979). Therapeutic use: C. Ortolani et al., Clin. Ter. 89, 391 (1979).

Methylcyclohexane CAS Registry Number: 108-87-2 甲基环己烷

Additional Names: Hexahydrotoluene; cyclohexylmethane
Percent Composition: C 85.62%, H 14.37%
Literature References: Prepn: F. Wreden, B. Znatowicz, Ann. 187, 161 (1877); E. Knoevenagel, ibid. 297, 113 (1897); and physical properties: J. P. Wibaut et al., Rec. Trav. Chim. 58, 12 (1939). Toxicology: J. F. Treon et al., J. Ind. Hyg. Toxicol. 25, 199 (1943). Dehydrogenation to produce motor fuel: N. Gruenenfelder et al., Proc. 20th Intersoc. Energy Convers. Eng. Conf. 2, 2.781 (1985). Kinetics of industrial dehydrogenation to toluene: A. Touzani et al., Stud. Surf. Sci. Catal. 19, 357 (1984); use of a membrane reactor to improve process: J. K. Ali, A. Baiker, Appl. Catal. A 155, 41 (1997).

Phosmet CAS Registry Number: 732-11-6 亚胺硫磷

CAS Name: Phosphorodithioic acid S-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl] O,O-dimethyl ester
Additional Names: phosphorodithioic acid O,O-dimethyl ester S-ester with N-(mercaptomethyl...
Literature References: Prepn: Fancher, US 2767194 (1956 to Stauffer). Activity: B. A. Butt, J. C. Keller, J. Econ. Entomol. 54, 813 (1961). GC determn in produce: M. A. Luke et al., J. Assoc. Off. Anal. Chem. 64, 1187 (1981). Toxicity study: T. B. Gaines, Toxicol. Appl. Pharmacol. 14, 515 (1969).

Thonzonium Bromide CAS Registry Number: 553-08-2 嘧苯十六铵

CAS Name: N-[2-[[(4-Methoxyphenyl)methyl]-2-pyrimidinylamino]ethyl]-N,N-dimethyl-1-hexadecanaminium bromide
Additional Names: hexadecyl[2-[(p-methoxybenzyl)-2-pyrimidinylamino]ethyl]dimethylamm...
Literature References: Prepn: Fand, US 2742470 (1956 to Nepera Chem.).

Dibutyl Phthalate CAS Registry Number: 84-74-2 邻苯二甲酸二正丁酯

CAS Name: 1,2-Benzenedicarboxylic acid dibutyl ester
Additional Names: n-butyl phthalate; phthalic acid dibutyl ester; DBP
Percent Composition: C 69.04%, H 7.97%, O 22.99%
Literature References: Prepn: Farrar, Wienkauff, Chem. Ind. (London) 1962, 2144. Manuf: Bruno, US 2628249 (1953 to Pittsburgh Coke Chemical). Toxicity study: C. C. Smith, Arch. Ind. Hyg. Occup. Med. 7, 310 (1953). Review of toxicology and human exposure: Toxicological Profile for Di-n-butyl phthalate (PB2001-109104, 2001) 225 pp.

Pentaerythritol Dichlorohydrin CAS Registry Number: 2209-86-1 洛丙二醇

CAS Name: 2,2-Bis(chloromethyl)-1,3-propanediol
Trademarks: Dispranol
Percent Composition: C 34.70%, H 5.82%, Cl 40.98%, O 18.49%
Literature References: Prepn: Fecht, Ber. 40, 3883 (1907); Rapoport, J. Am. Chem. Soc. 68, 341 (1946); Dee, US 2763679 (1956 to Heyden Chem.).

Methdilazine CAS Registry Number: 1982-37-2 甲吡吩嗪

CAS Name: 10-[(1-Methyl-3-pyrrolidinyl)methyl]-10H-phenothiazine
Percent Composition: C 72.93%, H 6.80%, N 9.45%, S 10.82%
Literature References: Prepn: Feldkamp, Wu, US 2945855 (1960 to Mead Johnson). Toxicity data: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).

Diquat Dibromide CAS Registry Number: 85-00-7 敌草快二溴盐

CAS Name: 6,7-Dihydrodipyrido[1,2-a:2',1'-c]pyrazinediium dibromide
Additional Names: 1,1'-ethylene-2,2'-dipyridylium dibromideTrademarks: Reglone (Syngenta)
Percent Composition: C 41.89%, H...
Literature References: Prepn: Fielden et al., US 2823987 (1958 to ICI). Herbicidal properties: Brian et al., Nature 181, 446 (1958). Environmental fate and toxicity: Simsiman et al., Residue Rev. 62, 131-174 (1976). Acute toxicity study: T. B. Gaines, R. E. Linder, Fundam. Appl. Toxicol. 7, 299 (1986). Review: Akhavein, Linscott, ibid. 23, 97-145 (1968).